Phospho-DCX (S376) Antibody

說明書

中文名稱：

磷酸化-DCX (S376)兔多克隆抗體
貨號：

CSB-PA007675
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O43602
基因名：

DCX
別名：

DBCN antibody; Dbct antibody; DC antibody; DCX antibody; DCX_HUMAN antibody; Doublecortex antibody; Doublin antibody; FLJ51296 antibody; Lis X antibody; Lis-X antibody; Lissencephalin X antibody; Lissencephalin-X antibody; Lissencephaly X linked antibody; Lissencephaly X linked doublecortin antibody; LISX antibody; Neuronal migration protein doublecortin antibody; OTTHUMP00000023859 antibody; OTTHUMP00000023860 antibody; OTTHUMP00000216315 antibody; OTTHUMP00000216316 antibody; SCLH antibody; XLIS antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from Human Doublecortin around the phosphorylation site of S376.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:5000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.
基因功能參考文獻：
1. Age-associated expression of the proliferation and immature neuron markers MKI67 and DCX, respectively, was unrelated, suggesting that neurogenesis-associated processes are independently altered at these points in the development from stem cell to neuron. PMID: 28766905
2. specifically recognizes compacted GDP-like microtubule lattice PMID: 27238282
3. this suggests that the microtubule-interacting doublecortin domain observed in cryo-electron micrographs is the C-terminal domain rather than the N-terminal one. PMID: 27226599
4. From this family, we conclude that a DCX mutation causes a pleiotropic phenotype in the female even if X chromosome inactivation pattern is not skewed, and the novel missense mutation in DCX produced relatively mild dysfunction of the doublecortin protein. PMID: 25868952
5. We identified a novel DCX mutation c.785A > G, p.Asp262Gly in a family with X-linked lissencephaly and subcortical band heterotopia PMID: 27292316
6. In high-risk metastatic Neuroblastoma, TH and DCX mRNA quantification could be used for the assessment of response to treatment and for early detection of progressive disease or relapses. PMID: 26498952
7. Results point to a critical role of doublecortin in the formation of the neuromuscular junctions. PMID: 25817838
8. It was conclude that microtubule ends have two distinct features that proteins can recognize independently, namely a structural feature related to curvature and nucleotide state. PMID: 25283777
9. DCX-positive cells occur in a wide range of hypothalamic nuclei in humans, mice and sheep. PMID: 24288185
10. human DCX protein was expressed in human adipose stem cells, collagen II was decreased while aggrecan, matrilin 2, and GDF5 were increased during the 14-day pellet culture. PMID: 24758934
11. We propose that DCDC2 is a tumor suppressor gene of HCC. PMID: 24034596
12. in utero doublecortin knockdown, but not knockout, shows a neocortical neuronal migration phenotype. PMID: 24945770
13. Immunoblots revealed that depressed subjects displayed increased expression of doublecortin. PMID: 23260340
14. coexpression of DCX and SPARC collaboratively diminished radioresistance of glioma cells. PMID: 23846421
15. DCX is dispensable for the development of new neurons in adult mice PMID: 23667508
16. one deleterious mutation in the DCX gene was identified in a 5-year-old girl with lissencephaly spectrum PMID: 23583063
17. This finding points to the possible implication of mosaic deletions in the DCX gene in unexplained forms of subcortical band heterotopia (SBH) and may allow for detection of SBH prenatally. PMID: 22833188
18. DCX binds to polymerization intermediates at growing microtubule ends, in support of a mechanism for stabilizing 13-protofilament microtubules. PMID: 22727374
19. Data report a negative correlation between DCX mRNA expression and white matter neuron density in schizophrenia, in contrast to a positive correlation in human development where DCX mRNA and white matter neuron density are higher earlier in life. PMID: 21966452
20. Up-regulation of doublecortin is associated with brain damage in children with acute lymphoblastic leukemia PMID: 21846577
21. DCX synthesis induces apoptosis in brain tumor stem cells (BTSC) through a novel JNK1/neurabin II/DCX/PP1/caspase-3 pathway. PMID: 21477071
22. study describes male siblings with Lennox-Gastaut syndrome and pachygyria with a novel missense mutation in the DCX gene PMID: 20726879
23. The DCX binding on the microtubules surface indirectly stabilizes conserved tubulin-tubulin lateral contacts in the microtubules lumen, operating independently of the nucleotide bound to tubulin. PMID: 20974813
24. variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, have roles in memory and general cognitive abilities PMID: 19844571
25. Evidence for a role for miR-128 in neuroblastoma progression and aggressiveness through reelin and DCX expression is reported. PMID: 19713529
26. During development of the cerebral cortex DCX is expressed in both pyramidal and non-pyramidal migrating cells, as well as in Cajal-Retzius cells. PMID: 12427674
27. Missense DCX mutations may manifest as non-syndromic mental retardation with cryptogenic epilepsy in female subjects and subcortical band heterotopia (SBH) in boys. PMID: 12838518
28. Different clinical and morphological phenotypes in monozygotic twins with identical DCX mutation. PMID: 14999500
29. both mutant and wild type DCX are able to bind and bundle microtubules; however, mutants possess a decreased ability to perturb the mitotic machinery, to cause abnormal spindle orientation, and to impair mitotic progression PMID: 15045646
30. DCX maps at Xq22.3 and is caused by a homozygous mutation. It acts during corticogenesis on radial migratory pathways. PMID: 15057976
31. We analysed the human DCX regulatory sequence and confined it to a 3.5-kb fragment upstream of the ATG start codon. This fragment is sufficient and specific to drive expression of reporter genes in embryonic and adult neuronal precursors PMID: 15663475
32. doublecortin (DCX) gene as a new molecular marker of neuroblastoma cells PMID: 15714065
33. Collectively, the immunohistochemistry, Western blots and Northern blots conclusively demonstrate expression of DCX by human brain tumors. PMID: 16195916
34. Doublecortin can be regarded as specific neuronal marker only in normal developing brain, but lacks specificity in glioneuronal and glial tumours and other non-neuronal human tissues where it is expressed in a wide variety of tumours and tissues. PMID: 16520969
35. X-ray structure of a mutant of N-DCX, in which the C-terminal fragment (residues 139-147) unexpectedly shows an altered, "open" conformation PMID: 16835924
36. Our data in the mouse, identifying roles for Dcx in hippocampal and corpus callosal development, might suggest intrinsic roles for human DCX in the development of these structures. PMID: 17111359
37. Doublecortin (DCX) is one of the three genes found from Affymetrix gene chip analysis related to glioma patient survival. PMID: 17178868
38. MLPA uncovers large genomic deletions of the DCX gene in a subset of patients with SBH in whom no mutations are found after gene sequencing. Deletions of DCX are an underascertained cause of SBH. PMID: 17283321
39. Results demonstrate that DCX can be used as a marker to distinguish articular chondrocytes from other chondrocytes and to evaluate the quality of tissue engineered or regenerated cartilage in terms of their "articular" or "non-articular" nature. PMID: 17897623
40. Doublecortin is applicable for the detection of individual infiltrating glioma cells when combined with other markers. PMID: 18415660
41. X-linked lissencephaly patients with mutations in the C-DC domain tended to have a less severe lissencephaly (grade 4-5 in 58.3%) compared with those in the N-DC domain (grade 4-5 in 36.3%. PMID: 18685874
42. intragenic deletions and duplications of the DCX gene account for a significant number of patients with isolated lissencephaly sequence and subcortical band heterotopia, where no molecular defect had previously been identified. PMID: 19050731
43. Doublecortin (DCX) upregulation, correlates with better neurologic outcome in children following traumatic head injury. PMID: 19221293
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相關疾病：

Lissencephaly, X-linked 1 (LISX1); Subcortical band heterotopia X-linked (SBHX)
亞細胞定位：

Cytoplasm. Cell projection, neuron projection.
組織特異性：

Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low ex
數據庫鏈接：

HGNC: 2714

OMIM: 300067

KEGG: hsa:1641

STRING: 9606.ENSP00000337697

UniGene: Hs.34780

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