Phospho-ATF1 (S63) Antibody

說明書

中文名稱：

磷酸化-ATF1 (S63)兔多克隆抗體
貨號：

CSB-PA020018
規格：

￥1090
圖片：
Western blot analysis of Mouse-kidney KB 293T 3T3 lysis using Phospho-ATF-1 (S63) antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P18846
基因名：

ATF1
別名：

Activating transcription factor 1 antibody; ATF 1 antibody; atf1 antibody; ATF1 EWS fusion gene antibody; ATF1 FUS fusion gene antibody; ATF1_HUMAN antibody; cAMP dependent transcription factor 1 antibody; cAMP-dependent transcription factor ATF-1 antibody; Cyclic AMP dependent transcription factor ATF 1 antibody; Cyclic AMP dependent transcription factor ATF1 antibody; Cyclic AMP-dependent transcription factor ATF-1 antibody; EWS AFT1 antibody; FUS ATF 1 antibody; FUS/ATF 1 antibody; Protein TREB36 antibody; RNA binding protein activating transcription factor 1 fusion protein antibody; TREB 36 antibody; TREB36 antibody; TREB36 protein antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from Human ATF-1 around the phosphorylation site of S63.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:5000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
基因功能參考文獻：
1. LncRNA GHET1 was intimately involved in the occurrence and development of HCC through regulating ATF1. PMID: 28772210
2. a breakpoint in the EWSR1-ATF1 fusion to be the same as that reported in HCCC. Established CCOC-T cells grew extremely slowly, but the cells showed highly invasive activity PMID: 28559020
3. Pin1 is a novel regulator of ATF1 at Thr184. PMID: 28032861
4. Case Reports: maxillary sinus clear cell carcinomas with EWSR1-ATF1 gene fusion. PMID: 27916624
5. Results expand the spectrum of tumor types harboring EWSR1/FUS-ATF1 gene fusions to include a subgroup of conventional epithelioid malignant mesothelioma. PMID: 28505004
6. Report a distinct group of myxoid mesenchymal neoplasms occurring in children or young adults with a predilection for intracranial locations with EWSR1-AFT1/CREB1/CREM fusions. PMID: 28009602
7. our results demonstrated that miR-30a may modulate the radiosensitivity of non-small cell lung cancer (NSCLC) through reducing the function of ATF1 in phosphorylation of ATM and have potential therapeutic value. PMID: 28259977
8. genetic association studies in a population in China: Data suggest that an SNP in ATF1 (rs11169571) is associated with essential hypertension in the population studied; altered binding of microRNA-1283 appears to be involved. PMID: 26149214
9. EWSR1-ATF1 fusion gene was found in hyalinizing clear cell carcinoma PMID: 25359601
10. Heme activates the ATF1 pathway in human macrophages via AMPK, and that a similar response occurs after treatment of cells with metformin. PMID: 24051143
11. ATF1 protein expression was significantly lower in colorectal cancer tissues than corresponding normal tissues; patients with higher ATF1 expression levels have a significantly higher survival rate than those with lower expression PMID: 22631637
12. Review: discuss clinicopathologic and molecular features of group of neoplasms unified by the presence of EWSR1-CREB1 and EWSR1-ATF1 genetic fusions. PMID: 22510762
13. ATF-1 mediates HO-1 induction by heme and drives macrophage adaptation to intraplaque hemorrhage. PMID: 22052915
14. Hyalinizing clear-cell carcinoma is a unique low-grade salivary carcinoma that consistently harbors EWSR1-ATF1 fusion. PMID: 21484932
15. Differential expression of CREB/ATF transcription factors could be observed on neurogenic induction, pointing to a decisive role of the cAMP-CREB/ATF system. PMID: 20945072
16. An increase in phosphorylation of CREB/ATF-1 in human dental pulp cells was noted after exposure to PGF2alpha for 1-20 min,with a maximal induction at 10 min. PMID: 20536573
17. DNA cytosine methylation in the bovine leukemia virus promoter has a role in direct inhibition of cAMP-responsive element (CRE)-binding protein/CRE modulator/activation transcription factor binding PMID: 20413592
18. Composition and function of AP-1 transcription complexes during muscle cell differentiation PMID: 11877423
19. Molecular genetic characterization of the EWS/ATF1 fusion gene in clear cell sarcoma of tendons and aponeuroses. PMID: 11992546
20. APC inhibited both the binding of NF-kB to target sites and the degradation of I kappa B alpha, and inhibited both the binding of activator protein-1 (AP-1) to target sites and the activation of mitogen-activated protein kinase pathways. PMID: 12195699
21. ATF1 plays an important role in the trans-activation of the MHC class II trans-activator (CIITA) promoter III in B cells. PMID: 12391222
22. identification of its target genes as a chimeric protein with EWS PMID: 12527906
23. Results demonstrate that c-Src and TRAF6 are key mediators of interleukin-1-induced AP-1 activation and provide evidence of cross talk between c-Src and TRAF6 molecules through PI3 kinase-Akt-JNK pathways. PMID: 12631284
24. activating transcription factor 1(AP-1) motif is important in determining the up-regulatory effects induced by leptin on aromatase expression in MCF-7 breast cancer cells PMID: 12734209
25. transcriptional activation of the interleukin-8 promoter by bradykinin involves the prostanoid-independent activation of nuclear factor-kappaB, and prostanoid-dependent activation of activating protein-1 and nuclear factor-interleukin-6 PMID: 12748173
26. Blockade of AP-1 activation by the recombinant adenovirus containing a dominant negative c-Jun markedly reduced the IL-1beta-and TGF-beta1-induced IL-11 mRNA expression. PMID: 12760902
27. The role of activator protein-1 in regulating the promoter of IFGBP4 was studied in CaCo-2 cells. PMID: 14767471
28. some protease inhibitors might act as stress and induced TF expression with direct phosphorylation of JNK and p38, followed by phosphorylation and activation of AP-1 in monocytic cells PMID: 15041276
29. Simultaneous expression of the EWSR1-ATF1 and MITF-M transcripts in clear cell carcinoma has led to the proposal that the MITF-M promoter is transactivated by EWSR1-ATF1. PMID: 15884099
30. CREB/ATF1 and c-Jun were shown to bind to an oligonucleotide encompassing a distal, conserved CREB/AP1 site in the 5'-flanking region of the MUC2 gene, and this cis element was shown to mediate promoter reporter activation by VIP PMID: 16227528
31. There was evidence of ATF1 oncogene protein fusion in this sarcoma. PMID: 16327442
32. The cytokines TNFalpha and GM-CSF activate CAEV transcription, and this effect occurs independently of AP-1. PMID: 16716376
33. PIAS3 is a new regulator of ATF1 that regulates the ARE-mediated transcription of the ferritin H gene PMID: 17565989
34. CDK3 phosphorylates activating transcription factor 1 (ATF1)and enhances the transactivation and transcriptional activities of ATF1. PMID: 18794154
35. Thirteen of 15 cases of clear cell sarcoma harbored a type 1 chimeric transcript (EWSR1 exon 8/ATF1 exon 4) PMID: 19561568
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相關疾?。?/div>
Angiomatoid fibrous histiocytoma (AFH)
亞細胞定位：

Nucleus.
蛋白家族：

BZIP family, ATF subfamily
數據庫鏈接：

HGNC: 783

OMIM: 123803

KEGG: hsa:466

STRING: 9606.ENSP00000262053

UniGene: Hs.648565

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