ATF1 Antibody
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中文名稱：ATF1兔多克隆抗體
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貨號：CSB-PA968509
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規格：￥2024
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圖片：
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Western blot analysis of extracts from COLO205 cells, HeLa cells and HepG2 cells, using ATF1 antibody. -
Immunofluorescence analysis of HUVEC cells, using ATF1 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ATF1 Polyclonal antibody
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Uniprot No.：
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基因名：ATF1
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from internal of Human ATF1.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IF 1:100-1:500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
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基因功能參考文獻：
- LncRNA GHET1 was intimately involved in the occurrence and development of HCC through regulating ATF1. PMID: 28772210
- a breakpoint in the EWSR1-ATF1 fusion to be the same as that reported in HCCC. Established CCOC-T cells grew extremely slowly, but the cells showed highly invasive activity PMID: 28559020
- Pin1 is a novel regulator of ATF1 at Thr184. PMID: 28032861
- Case Reports: maxillary sinus clear cell carcinomas with EWSR1-ATF1 gene fusion. PMID: 27916624
- Results expand the spectrum of tumor types harboring EWSR1/FUS-ATF1 gene fusions to include a subgroup of conventional epithelioid malignant mesothelioma. PMID: 28505004
- Report a distinct group of myxoid mesenchymal neoplasms occurring in children or young adults with a predilection for intracranial locations with EWSR1-AFT1/CREB1/CREM fusions. PMID: 28009602
- our results demonstrated that miR-30a may modulate the radiosensitivity of non-small cell lung cancer (NSCLC) through reducing the function of ATF1 in phosphorylation of ATM and have potential therapeutic value. PMID: 28259977
- genetic association studies in a population in China: Data suggest that an SNP in ATF1 (rs11169571) is associated with essential hypertension in the population studied; altered binding of microRNA-1283 appears to be involved. PMID: 26149214
- EWSR1-ATF1 fusion gene was found in hyalinizing clear cell carcinoma PMID: 25359601
- Heme activates the ATF1 pathway in human macrophages via AMPK, and that a similar response occurs after treatment of cells with metformin. PMID: 24051143
- ATF1 protein expression was significantly lower in colorectal cancer tissues than corresponding normal tissues; patients with higher ATF1 expression levels have a significantly higher survival rate than those with lower expression PMID: 22631637
- Review: discuss clinicopathologic and molecular features of group of neoplasms unified by the presence of EWSR1-CREB1 and EWSR1-ATF1 genetic fusions. PMID: 22510762
- ATF-1 mediates HO-1 induction by heme and drives macrophage adaptation to intraplaque hemorrhage. PMID: 22052915
- Hyalinizing clear-cell carcinoma is a unique low-grade salivary carcinoma that consistently harbors EWSR1-ATF1 fusion. PMID: 21484932
- Differential expression of CREB/ATF transcription factors could be observed on neurogenic induction, pointing to a decisive role of the cAMP-CREB/ATF system. PMID: 20945072
- An increase in phosphorylation of CREB/ATF-1 in human dental pulp cells was noted after exposure to PGF2alpha for 1-20 min,with a maximal induction at 10 min. PMID: 20536573
- DNA cytosine methylation in the bovine leukemia virus promoter has a role in direct inhibition of cAMP-responsive element (CRE)-binding protein/CRE modulator/activation transcription factor binding PMID: 20413592
- Composition and function of AP-1 transcription complexes during muscle cell differentiation PMID: 11877423
- Molecular genetic characterization of the EWS/ATF1 fusion gene in clear cell sarcoma of tendons and aponeuroses. PMID: 11992546
- APC inhibited both the binding of NF-kB to target sites and the degradation of I kappa B alpha, and inhibited both the binding of activator protein-1 (AP-1) to target sites and the activation of mitogen-activated protein kinase pathways. PMID: 12195699
- ATF1 plays an important role in the trans-activation of the MHC class II trans-activator (CIITA) promoter III in B cells. PMID: 12391222
- identification of its target genes as a chimeric protein with EWS PMID: 12527906
- Results demonstrate that c-Src and TRAF6 are key mediators of interleukin-1-induced AP-1 activation and provide evidence of cross talk between c-Src and TRAF6 molecules through PI3 kinase-Akt-JNK pathways. PMID: 12631284
- activating transcription factor 1(AP-1) motif is important in determining the up-regulatory effects induced by leptin on aromatase expression in MCF-7 breast cancer cells PMID: 12734209
- transcriptional activation of the interleukin-8 promoter by bradykinin involves the prostanoid-independent activation of nuclear factor-kappaB, and prostanoid-dependent activation of activating protein-1 and nuclear factor-interleukin-6 PMID: 12748173
- Blockade of AP-1 activation by the recombinant adenovirus containing a dominant negative c-Jun markedly reduced the IL-1beta-and TGF-beta1-induced IL-11 mRNA expression. PMID: 12760902
- The role of activator protein-1 in regulating the promoter of IFGBP4 was studied in CaCo-2 cells. PMID: 14767471
- some protease inhibitors might act as stress and induced TF expression with direct phosphorylation of JNK and p38, followed by phosphorylation and activation of AP-1 in monocytic cells PMID: 15041276
- Simultaneous expression of the EWSR1-ATF1 and MITF-M transcripts in clear cell carcinoma has led to the proposal that the MITF-M promoter is transactivated by EWSR1-ATF1. PMID: 15884099
- CREB/ATF1 and c-Jun were shown to bind to an oligonucleotide encompassing a distal, conserved CREB/AP1 site in the 5'-flanking region of the MUC2 gene, and this cis element was shown to mediate promoter reporter activation by VIP PMID: 16227528
- There was evidence of ATF1 oncogene protein fusion in this sarcoma. PMID: 16327442
- The cytokines TNFalpha and GM-CSF activate CAEV transcription, and this effect occurs independently of AP-1. PMID: 16716376
- PIAS3 is a new regulator of ATF1 that regulates the ARE-mediated transcription of the ferritin H gene PMID: 17565989
- CDK3 phosphorylates activating transcription factor 1 (ATF1)and enhances the transactivation and transcriptional activities of ATF1. PMID: 18794154
- Thirteen of 15 cases of clear cell sarcoma harbored a type 1 chimeric transcript (EWSR1 exon 8/ATF1 exon 4) PMID: 19561568
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相關疾病：Angiomatoid fibrous histiocytoma (AFH)
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亞細胞定位：Nucleus.
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蛋白家族：BZIP family, ATF subfamily
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