PTGES2 Antibody

說明書

中文名稱：

PTGES2兔多克隆抗體
貨號：

CSB-PA562484
規(guī)格：

￥1100
圖片：
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela cells, A549 cells, human liver cancer tissue, lncap cells, Primary antibody: CSB-PA562484(PTGES2 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
其他：

產(chǎn)品詳情
產(chǎn)品評價
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靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q9H7Z7
基因名：

PTGES2
別名：

C9orf15 antibody; FLJ14038 antibody; Gamma interferon activated transcriptional element binding factor 1 antibody; GATE binding factor 1 antibody; GBF 1 antibody; GBF1 antibody; Membrane associated prostaglandin E synthase 2 antibody; MGC11289 antibody; Microsomal prostaglandin E synthase 2 antibody; mPGES 2 antibody; mPGES-2 antibody; PGES2 antibody; PGES2_HUMAN antibody; Prostaglandin E synthase 2 antibody; Prostaglandin E synthase 2 truncated form antibody; PTGES 2 antibody; PTGES2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Fusion protein of Human PTGES2
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate. In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA).
基因功能參考文獻：
1. Four single nucleotide polymorphisms in two genes in the PGE2 family, PTGES2 and PTGER4, were significantly associated with primary graft dysfunction after lung transplantation. PMID: 24467603
2. high immunoreactivity of mPGES-2 in pyramidal neurons of AD brains indicates that it might have a potential role in the functional replacement of cytosolic PGES or inactive mPGES-1 in later stages of Alzheimer disease PMID: 19664621
3. Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression PMID: 11847219
4. role in regulating interferon-gamma-dependent gene expression PMID: 12050152
5. 110Cys is essential in the active site of membrane-associated prostaglandin E synthase-2 PMID: 12804604
6. Transactivators GBF1 and CCAAT/enhancer-binding protein-beta physically interact to induce interferon-gamma-regulated transcription; a 37-aa long peptide derived from the GBF1 protein can associate with C/EBP-beta in an IFN-inducible manner. PMID: 15879117
7. alphaTOS inhibits COX activity, thereby inhibiting PGE2 production in human lung epithelial cells PMID: 16714329
8. study obtained evidence from two Caucasian study populations that the His298-allele of PTGES2 Arg298His confers to reduced risk of type 2 diabetes PMID: 17566096
9. Carbonyl reductase-1 (CBR1), microsomal prostaglandin E synthase-1 and 2 (mPGES-1, mPGES-2), cytosolic prostaglandin E synthase (cPGES), aldoketoreductase (AKR1C1) and prostaglandin F synthase (AKR1C3) were all expressed in hair follicles. PMID: 17697149
10. risk-reducing effects of the minor His allele of the prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism could be mediated partly by lowered body mass index (BMI) PMID: 17979097
11. all three terminal prostaglandin synthases, mPGES-1, mPGES-2, and cPGES, are over-expressed in human gliomas PMID: 19347995
12. A marginal but significant influence of the PTGES2 298H single nucleotide polymorphism on BMI was found in a large population-based study. PMID: 19371221
13. These results indicate that mPGES-1 and mPGES-2 may each play a role in colorectal cancer progression. PMID: 19412621
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亞細胞定位：

Golgi apparatus membrane; Single-pass membrane protein.; [Prostaglandin E synthase 2 truncated form]: Cytoplasm, perinuclear region.
蛋白家族：

GST superfamily
組織特異性：

Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes
數(shù)據(jù)庫鏈接：

HGNC: 17822

OMIM: 608152

KEGG: hsa:80142

STRING: 9606.ENSP00000345341

UniGene: Hs.495219

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