PRODH Antibody

中文名稱：

PRODH兔多克隆抗體
貨號：

CSB-PA018744LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Rat liver tissue
All lanes: PRODH antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 69, 57, 60 kDa
Observed band size: 69 kDa

IHC image of CSB-PA018744LA01HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA018744LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PRODH Polyclonal antibody
Uniprot No.：

O43272
基因名：

PRODH
別名：

HSPOX2 antibody; mitochondrial antibody; P53 induced gene 6 protein antibody; p53-induced gene 6 protein antibody; PIG6 antibody; POX antibody; PROD_HUMAN antibody; PRODH 1 antibody; PRODH 2 antibody; PRODH antibody; PRODH1 antibody; PRODH2 antibody; Proline dehydrogenase antibody; proline dehydrogenase (oxidase) 1 antibody; proline dehydrogenase (proline oxidase) antibody; Proline dehydrogenase 1 antibody; Proline dehydrogenase 1, mitochondrial antibody; Proline oxidase 1 antibody; Proline oxidase 2 antibody; Proline oxidase antibody; Proline oxidase, mitochondrial antibody; Proline oxidase, mitochondrial precursor antibody; SCZD4 antibody; TP53I6 antibody; tumor protein p53 inducible protein 6 antibody
宿主：

Rabbit
反應種屬：

Human, Rat
免疫原：

Recombinant Human Proline dehydrogenase 1, mitochondrial protein (71-134AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PRODH Antibody (CSB-PA018744LA01HU)，的標記方式是Non-conjugated。對于PRODH Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA018744LB01HU	PRODH Antibody, HRP conjugated	ELISA
FITC	CSB-PA018744LC01HU	PRODH Antibody, FITC conjugated
Biotin	CSB-PA018744LD01HU	PRODH Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Converts proline to delta-1-pyrroline-5-carboxylate.
基因功能參考文獻：
1. PRODH1-mediated proline metabolism promotes pancreatic ductal adenocarcinoma growth. PMID: 28685754
2. Here, we show that Prodh-deficient mice with elevated CNS L-proline display specific deficits in high-frequency GABA-ergic transmission and gamma-band oscillations. We find that L-proline is a GABA-mimetic and can act at multiple GABA-ergic targets PMID: 27705802
3. PRODH/POX knockdown decreased DNA and collagen biosynthesis, whereas increased prolidase activity and intracellular proline level in MCF-7shPRODH/POX cells. PMID: 28942439
4. this study shows that PRODH plays a causative role in DNA damage-induced senescence through the enzymatic generation of reactive oxygen species PMID: 28264926
5. the frequency of a recurrent small 22q11.2 deletion encompassing PRODH and the neighboring DGCR6 gene in three case-control studies, was studied. PMID: 26978485
6. The findings support a major role for the PRODH 757TT, 1766GG, and 1852AA genotypes alone and in combination for schizophrenia susceptibility. PMID: 26436492
7. Thirty-five percent of the subjects were hyperprolinemic, allele carriers of PRODH rs450046 had a lower full-scale intelligence compared to T allele carriers PMID: 26068888
8. GR and KLF15 physically interact via low affinity GR binding sites within glucocorticoid response elements (GREs) for PRODH and AASS that contribute to combinatorial regulation with KLF15. PMID: 26088140
9. results suggest that PRODH and COMT may interact to contribute to the ASD phenotype in individuals with VCFS PMID: 25325218
10. Functional COMT, but not PRODH, variant affects IQ and executive functions in 22q11.2DS subjects during neurodevelopment with a maximal effect at adulthood PMID: 24853458
11. Data indicate that a functional proline dehydrogenase (PRODH) variant associated with schizophrenia that may have a neurochemical impact, altering brain function, but is not responsible for the cortical reductions found in the disorder. PMID: 24498354
12. The current study demonstrates that sensory gating impairments that are typical of schizophrenia are found in 22q11.2DS subjects. Our results further suggest that COMT and PRODH genetic variations contribute to sensory gating. PMID: 23910792
13. PRODH, but not PRODH2, expression is under the control of p53 family members, specifically p53 and p73. PMID: 23861960
14. Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH. PMID: 24218577
15. distinct molecular alterations of the PRODH gene result in abnormal proline levels. PMID: 23462603
16. results provide evidence that PRODH is essential in proline protection against hydrogen peroxide-mediated cell death and that proline/PRODH helps activate Akt in cancer cells PMID: 22796327
17. There is no association between proline dehydrogenase (oxidase) 1 polymorphisms and schizophrenia in Korean population PMID: 21960278
18. For a number of genes affected by de novo copy number variants CNVs in autism (CNTNAP2, ZNF214, ARID1B, Proline Dehydrogenase), reduced transcript expression may be a mechanism of pathogenesis during neurodevelopment. PMID: 21448237
19. miR-23b, by targeting proline oxidase, could function as an oncogene. PMID: 20562915
20. POX is critical in the cellular response to the noxious effects of oxLDL by activating protective autophagy. PMID: 19942609
21. Proline oxidase induces apoptosis in tumor cells PMID: 12514185
22. A complete homozygous PRODH deletion has been identified in a child with type I hyperprolinemia with severe neurological manifestations. PMID: 12525555
23. Genetic analysis of PRODH reveals no association with schizophrenia. PMID: 12815738
24. Finding supports a role for the PRODH locus in schizophrenia. PMID: 15274030
25. Results suggest that the molecular basis for increased plasma proline levels in schizophrenic subjects carrying the missense mutation Leu441Pro is due to decreased stability of human PRODH2. PMID: 15449943
26. No association was found between common PRODH polymorphisms and any of the psychotic disorders. Five rare PRODH alterations (including a complete PRODH deletion and four missense substitutions) were associated with hyperprolinemia. PMID: 15494707
27. severe hyperprolinemia (>800 microM) occurs in individuals with large deletions and/or PRODH missense mutations PMID: 15662599
28. proline oxidase mediates apoptosis through the generation of proline-dependent ROS, which then mobilize calcium and activate calcineurin PMID: 15914462
29. proline oxidase may modulate apoptosis signals induced by p53 or other anti-cancer agents and enhance apoptosis in stress situations PMID: 16619034
30. this meta-analysis did not find statistically significant evidence for association between RGS4 and PRODH and schizophrenia on the basis of either allelic or genotypic analysis. PMID: 16791139
31. In the presence of proline, high POX activity is sufficient to induce mitochondria-mediated apoptosis. PMID: 16874462
32. Analysis of the PRODH gene coding sequence variations,predicted that POX residual activity results into HPI, whereas residual activity in the 30-50% range is associated either with normal plasma proline levels or with mild-to-moderate hyperprolinemia. PMID: 17135275
33. Patients with biallelic PRODH alterations resulting in severely impaired proline oxidase activity had an early onset and severe neurological features. PMID: 17412540
34. we found evidence for COMT and PRODH epistasis: in patients with a COMT Val allele (rs4680) and with one or two mutated PRODH alleles, we observed increased WM density in the left inferior frontal lobe. PMID: 17504246
35. Molecular genetic analysis of COMT, PRODH and BDNF genes showed no significant effects of any variants on schizotypal components or factors of SPQ after correction for multiple testing. PMID: 17604122
36. In conjunction with the chromosomal location of PRODH, study findings suggest a potential involvement of this gene in the 22q11-associated cognitive, psychiatric and behavioral phenotypes. PMID: 18163391
37. Four Italian children with Type I hyperprolinemia presenting epilepsy, mental retardation, and behavioral disorders for PRODH gene mutations were screened, and a genotype-phenotype correlation was attempted. PMID: 18197084
38. Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers PMID: 18794809
39. A family-based sample showed functional polymorphisms in POX are associated with schizophrenia, with protective and risk alleles having opposite effects on POX activity. PMID: 18989458
40. Kinetic studies of the structural determinants of PRODH substrate specificity focus on how the enzyme discriminates between two closely related molecules, proline and hydroxyproline. PMID: 19140736
41. We assessed the relationship between these high-risk PRODH polymorphisms and schizophrenia-related endophenotypes PMID: 19232576
42. Glucose deprivation increased intracellular proline levels, and expression of POX activated the pentose phosphate pathway. PMID: 19415679
43. POX is a mitochondrial tumor suppressor and a potential target for cancer therapy. PMID: 19654292
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相關疾病：

Hyperprolinemia 1 (HYRPRO1); Schizophrenia 4 (SCZD4)
亞細胞定位：

Mitochondrion matrix.
蛋白家族：

Proline oxidase family
組織特異性：

Expressed in lung, skeletal muscle and brain, to a lesser extent in heart and kidney, and weakly in liver, placenta and pancreas.
數據庫鏈接：

HGNC: 9453

OMIM: 181500

KEGG: hsa:5625

STRING: 9606.ENSP00000349577

UniGene: Hs.517352

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