PRC1 Antibody
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中文名稱：PRC1兔多克隆抗體
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貨號：CSB-PA102179
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA102179(PRC1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：PRC1
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別名：Anaphase spindle elongation 1 homolog antibody; ASE1 antibody; PRC1 antibody; PRC1_HUMAN antibody; Protein regulating cytokinesis 1 antibody; Protein regulator of cytokinesis 1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Fusion protein of Human PRC1
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression.
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基因功能參考文獻：
- PRC1 was identified as a type 2 diabetes susceptibility gene. PRC1 plays a role in insulin secretion in vitro. PMID: 28580277
- We discuss targeting PRC1 within the complementary approaches of either normalizing chromosomal instability in aneuploid cancers or creating chromosomal chaos in genomically stable cancers to induce apoptosis. PMID: 29413422
- PRC1 mRNA and protein expressions were upregulated in lung adenocarcinoma tissues. PRC1 expression was significantly correlated with the Wnt/beta-catenin signaling pathway. PMID: 28646916
- We finally confirmed that PRC1 is a novel downstream target of piperlongumine in gastric cancer. Our findings supported the oncogenic role of PRC1 in gastric carcinogenesis. PRC1 might serve as a prognostic biomarker and potential therapeutic target for gastric carcinoma. PMID: 28190297
- These findings suggest that the identified APLP2, RRM2, and PRC1 signature could be useful for distinguishing between benign (follicular adenoma) and malignant (follicular carcionma and follicular variant of papillary carcinoma) tumors of the thyroid follicular epithelium. PMID: 27796194
- Near-atomic cryo-electron microscopy structure of PRC1 bound to the microtubule has been described. PMID: 27493215
- PRC1 is a novel Wnt target that functions in a positive feedback loop that reinforces Wnt signalling to promote early Hepatocellular Carcinoma recurrence. PMID: 26941395
- PRC1 rs10520699 and rs11852999 polymorphisms were associated with PRC1 transcript levels, but not with patients survival. PMID: 27505863
- These findings suggest that the aberrant expression of PRC1 may predict biochemical recurrence in men with prostate cancer highlighting its potential as a prognostic marker of this malignancy. PMID: 26898432
- PP2A-B55 dephosphorylates PRC1 at the metaphase to anaphase transition. This activity is regulated by the Greatwall (MASTL) kinase and its substrate ENSA, explaining the timing of PRC1 activation in anaphase. PMID: 24120663
- PRC1 complexes isolated from human cells contain multiple kinesins KIF4A, Kif20A, KIF23 and KIF14. PMID: 16431929
- PRC1 is a docking partner for the Polo kinase Plk1 in anaphase cells. During metaphase this is inhibited by Cdk1-cyclin B phosphorylation at T470 and T481. PMID: 17351640
- The presence of CBX4 or CBX8-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics. PMID: 24460908
- Study finds that frictional forces increase nonlinearly with microtubule-associated proteins (MAP) velocity across microtubules and depend on filament polarity, with NuMA's friction being lower when moving toward minus ends, EB1's lower toward plus ends, and PRC1's exhibiting no directional preference. PMID: 24725408
- Studies reveal how interactions between the conserved nonmotor MAP, PRC1, and the motor protein, kinesin-4, generate filament length-dependent tags at microtubule plus ends. PRC1 tags ends of microtubules in dividing cells and the size of these tags increases linearly with filament length. PMID: 23870126
- Different PRC1 paralog family members have nonredundant and locus-specific gene regulatory activities that are essential for human hematopoiesis. PMID: 23349393
- findings suggest that PRC1 is regulated by Plk1, rather than Cdk1 as previously proposed, because its activity must be spatiotemporally regulated both preanaphase and postanaphase, and Cdk1 activity is too binary for this purpose PMID: 22621898
- Two distinct mechanisms are involved in CBX2-mediated gene silencing. The short CBX2-2 isoform would repress the transcription in a PRC1-independent fashion, whereas gene repression by the long CBX2-1 isoform is mediated by the PRC1 protein complex. PMID: 22419124
- Cells depleted of PRC1 failed to form a polarized microtubule array or ectopic furrows following mitotic exit, and recruitment of Aurora B kinase, male germ cell Rac GTPase-activating protein, and RhoA to the cortex was impaired. PMID: 22323288
- The radiosensitizing effect of paclitaxel on KB cells may be due to the down-regulated expression of PRC1 and cyclin B2. PMID: 19664331
- PRC1's microtubule binding is mediated by a structured domain with a spectrin-fold and an unstructured Lys/Arg-rich domain. PMID: 20691902
- PRC1 is a microtubule-associated protein required to maintain the spindle midzone, and that distinct functions are associated with modular elements of the primary sequence. PMID: 12082078
- contributes to the correct formation of the spindle during the metaphase PMID: 14744859
- kinesin family member 4 and its binding partner PRC1 play essential roles in the organization of central spindles and midzone formation PMID: 15297875
- transcription is controlled by p53 via regulating cytokinesis PMID: 15531928
- PRC1 is a microtubule bundling protein that is critical to the formation of the central spindle, which is required for abscission but not for furrowing in mammalian cells PMID: 15616196
- role of PRC1 in midzone formation, indicate that cell cycle-dependent translocation of PRC1 by Kif4 is essential for midzone formation and cytokinesis. PMID: 15625105
- PRC1 is an essential factor in controlling the spatiotemporal formation of the midzone in human cells. PMID: 16603632
- suggest the involvement of a PRC1- kinesin family member 2C/mitotic centromere-associated kinesin complex in breast tumorigenesis, and this complex should be a promising target for the development of novel treatments for breast cancer PMID: 17233835
- These results provide a potential mechanistic basis for the defective cytokinesis phenotype exhibited by HSF2-/- cells, as well as suggest a potential role for PRC1 in HSF2-mediated gene bookmarking. PMID: 18570919
- Microtubule-associated protein (MAP) Prc1 facilitate Plk1 phosphorylation of HsCyk-4. PMID: 19468300
- Data propose that PRC1 forms a link between stabilization of CLASP1 association with central spindle microtubules and anti-parallel microtubule elongation. PMID: 19561070
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亞細胞定位：Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Midbody. Chromosome.
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蛋白家族：MAP65/ASE1 family
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組織特異性：Overexpressed in bladder cancer cells.
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數據庫鏈接：
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