PNMT Antibody

說明書

中文名稱：

PNMT兔多克隆抗體
貨號：

CSB-PA562058
規格：

￥1100
圖片：
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: K562 cells, human liver cancer tissue, Jurkat cells, A549 cells, Primary antibody: CSB-PA562058(PNMT Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
其他：

產品詳情
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靶點詳情

產品詳情

Uniprot No.：

P11086
基因名：

PNMT
別名：

Noradrenaline N-methyltransferase antibody; PENT antibody; Phenylethanolamine N-methyltransferase antibody; PNMT antibody; PNMT_HUMAN antibody; PNMTase antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Fusion protein of Human PNMT
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Converts noradrenaline to adrenaline.
基因功能參考文獻：
1. PNMT underexpression is associated with malignant pheochromocytoma and paraganglioma. PMID: 27007161
2. initial velocity studies on human PNMT in the absence and presence of product and dead end inhibitors. PMID: 24018397
3. The 2-SNP AA haplotype in the PNMT promoter is associated with decreased risk of essential hypertension in Han Chinese. PMID: 21866188
4. PNMT G-390A polymorphism is possibly associated with essential hypertension risk in male Chinese Han population. PMID: 19952402
5. In Caucasians, phenylethanolamine N-methyltransferase single nucleotide polymorphisms are associated with the development of acute kidney injury, disease severity, and in-hospital mortality. PMID: 20090367
6. PNMT variants in cis may interact with nuclear factors in trans to govern adrenergic activity. PMID: 20204374
7. Human PNMT has been crystallized in complex with an inhibitor and the cofactor product S-adenosyl-L-homocysteine and diffraction data measured from a cryocooled crystal extend to a resolution of 2.3 A. PMID: 11807261
8. pharmacologic and biochemical evidence of beta-carboline 2N-methyltransferase activity PMID: 11900856
9. Association between the phenylethanolamine N-methyltransferase gene and multiple sclerosis. PMID: 11958827
10. homozygosity/heterozygosity of the phenylethanolamine N-methyltransferase gene polymorphism was highly predictive of significant weight loss with sibutramine during the first 3 months of obesity treatment PMID: 12634439
11. genetic variants of PNMT may play a role in the development of essential hypertension. PMID: 14553966
12. Presence of local PNMT transcription in human heart after transplantation. PMID: 15848714
13. disulfide-linked dimers are as active as the monomeric enzyme indicating that the crystal structure of the protein is a valid target for inhibitor design. PMID: 15893506
14. Nicotinic stimuli appear to regulate expression of the epinephrine-synthesizing gene PNMT through a previously uncharacterized regulatory element. PMID: 15968085
15. Results suggest that PNMT catalyzes transfer of methyl to ligand amines only when "anchor" interactions, such as those identified for the beta-hydroxyls of p-octopamine and cis-AT, are present. PMID: 16363801
16. the differences in PNMT expression between normotensives and hypertensives are not determined by the polymorphisms in this gene, but rather by the interplay of gene expression regulators, which may vary among individuals PMID: 17645789
17. We examined the correlation between reward dependence (RD) trait, and 5 polymorphisms in genes of norepinephrine pathways. We found that rs3764351 in PNMT was significantly associated with reward dependence trait. PMID: 18702937
18. Haplotypes of the phenylethanolamine N-methyltransferase (PNMT), catechol-O-methyltransferase (COMT) have functionally important effects on alcohol-induced cardiovascular symptoms by affecting blood catecholamine levels. PMID: 18715275
19. The crystal structures illustrate the adaptability of the PNMT substrate binding site in accepting multi-fused ring systems, such as substituted norbornene, as well as noradrenochrome, the oxidation product of noradrenaline. PMID: 19570037
20. the reaction takes place via an SN2 mechanism with methyl transfer being rate-limiting PMID: 19733262
21. Oncogenomic recombination hotspot around the PPP1R1B-STARD3-TCAP-PNMT-PERLD1-ERBB2-C17orf37-GRB7 amplicon at human chromosome 17q12 is closely linked to evolutionary recombination hotspot around the GSDML-GSDM locus. PMID: 15010812
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蛋白家族：

Class I-like SAM-binding methyltransferase superfamily, NNMT/PNMT/TEMT family
數據庫鏈接：

HGNC: 9160

OMIM: 171190

KEGG: hsa:5409

STRING: 9606.ENSP00000269582

UniGene: Hs.1892

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