PHF5A Antibody

中文名稱：

PHF5A兔多克隆抗體
貨號：

CSB-PA017915EA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA017915EA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA017915EA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA017915EA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PHF5A Polyclonal antibody
Uniprot No.：

Q7RTV0
基因名：

PHF5A
別名：

1110007B08Rik antibody; Ac2 246 antibody; bK223H9.2 antibody; INI antibody; MGC1346 antibody; OTTHUMP00000198827 antibody; PHD finger 5a antibody; PHD finger like domain containing protein 5A antibody; PHD finger like domain protein 5A antibody; PHD finger protein 5A antibody; PHD finger-like domain protein 5A antibody; PHD finger-like domain-containing protein 5A antibody; Phf5a antibody; PHF5A_HUMAN antibody; Rds3 antibody; SAP14b antibody; SF3b14b antibody; Splicing factor 3B associated 14 kDa protein antibody; Splicing factor 3B-associated 14 kDa protein antibody; Transcription factor INI antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human PHD finger-like domain-containing protein 5A protein (1-110AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PHF5A Antibody (CSB-PA017915EA01HU)，的標記方式是Non-conjugated。對于PHF5A Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA017915EB01HU	PHF5A Antibody, HRP conjugated	ELISA
FITC	CSB-PA017915EC01HU	PHF5A Antibody, FITC conjugated
Biotin	CSB-PA017915ED01HU	PHF5A Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes. Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies. Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation. Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha.
基因功能參考文獻：
1. PHF5A-SF3B1 forms a central node for binding to splicing modulators PMID: 28541300
2. We found PHF5A, a component of the U2 snRNP mRNA splicing factor, blocks expression from recombinant Adeno-associated virus vectors PMID: 26244496
3. PHF5A facilitates recognition of exons with unusual C-rich 3' splice sites in thousands of essential genes PMID: 23651857
4. The molecular and genetic research in this paper is performed on mouse but the paper identifies and discusses homologues found in human genomic sequence databases. PMID: 12054543
亞細胞定位：

Nucleus. Nucleus speckle.
蛋白家族：

PHF5 family
數據庫鏈接：

HGNC: 18000

OMIM: 617846

KEGG: hsa:84844

STRING: 9606.ENSP00000216252

UniGene: Hs.474980

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