PHF5A Antibody
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中文名稱：PHF5A兔多克隆抗體
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貨號：CSB-PA017915GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：PHF5A
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別名：1110007B08Rik antibody; Ac2 246 antibody; bK223H9.2 antibody; INI antibody; MGC1346 antibody; OTTHUMP00000198827 antibody; PHD finger 5a antibody; PHD finger like domain containing protein 5A antibody; PHD finger like domain protein 5A antibody; PHD finger protein 5A antibody; PHD finger-like domain protein 5A antibody; PHD finger-like domain-containing protein 5A antibody; Phf5a antibody; PHF5A_HUMAN antibody; Rds3 antibody; SAP14b antibody; SF3b14b antibody; Splicing factor 3B associated 14 kDa protein antibody; Splicing factor 3B-associated 14 kDa protein antibody; Transcription factor INI antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human PHF5A
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) and trimethylated histone H3 'Lys-36' (H3K36me3), on PAF1C targets, self-renewal and pluripotency genes. Regulates RNA polymerase II promoter-proximal pause release of the PAF1C targets and self-renewal genes, and the levels of elongating ('Ser-2' phosphorylated) RNA polymerase II in their gene bodies. Regulates muscle specification in adult stem cells by stabilizing PAF1C in chromatin to promote myogenic differentiation. Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha.
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基因功能參考文獻：
- PHF5A-SF3B1 forms a central node for binding to splicing modulators PMID: 28541300
- We found PHF5A, a component of the U2 snRNP mRNA splicing factor, blocks expression from recombinant Adeno-associated virus vectors PMID: 26244496
- PHF5A facilitates recognition of exons with unusual C-rich 3' splice sites in thousands of essential genes PMID: 23651857
- The molecular and genetic research in this paper is performed on mouse but the paper identifies and discusses homologues found in human genomic sequence databases. PMID: 12054543
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亞細胞定位：Nucleus. Nucleus speckle.
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蛋白家族：PHF5 family
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數據庫鏈接：
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