NOS1 (Ab-852) Antibody
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中文名稱：NOS1 (Ab-852)兔多克隆抗體
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貨號：CSB-PA149037
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規格：￥2024
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圖片：
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Western blot analysis of extracts from Rat and Mouse brain tissue using nNOS(Ab-852) Antibody. -
Immunofluorescence staining of methanol-fixed Hela cells using nNOS(Ab-852) Antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) NOS1 Polyclonal antibody
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Uniprot No.：
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基因名：
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Peptide sequence around aa.850~854 (F-N-S-V-S) derived from Human nNOS.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:1000 IF 1:100-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
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基因功能參考文獻：
- Raynaud's phenomenon is associated with variation in gene NOS1 PMID: 29698501
- A meta-analysis was performed for the association of rs2682826, rs3782206, rs499776, rs3782219, rs41279104, rs3782221, rs1879417, rs4767540, rs561712, and rs6490121 polymorphisms with schizophrenia. rs3782206 showed a strong association with schizophrenia in allelic, homozygote, dominant, and recessive models in Asians. In Caucasians, rs499776 was associated in homozygote, dominant, and recessive models. PMID: 28795310
- Based on a quantitative comparison of their dendritic characteristics, the NOS1 neurons of humans and rats displayed a statistically significant difference PMID: 28720408
- The neuronal NOS exon 7 in the experimental group has a higher ratio of G/T and T/T genotypes than the control group, and also that the neuronal NOS intron 4 in the experimental group has a significantly higher a/b genotype than the control group. This suggests that the neuronal NOS gene mutation could be related to the development of osteonecrosis of the femoral head. PMID: 28770971
- High NOS1 expression is associated with Dilated Hearts. PMID: 27481317
- NOS1-ex1f VNTR is associated with white matter microstructure in females with ADHD and healthy females. PMID: 28589541
- selected nNOS polymorphisms do not significantly contribute to Parkinson's disease risk in north Indian population. PMID: 26081147
- Lysophosphatidylcholine induced nNOS uncoupling and nNOS(Ser852) phosphorylation, reduced NO and H2O2 production and improved superoxide production by modulating ERK1/2 activity in endothelial cells. PMID: 28235709
- NOS1 (missense variant rs79487279) was associated with bipolar disorder. PMID: 28195573
- Data suggest that NOS1 and NOS2 play roles in stress-induced surge in nitric oxide (NO) production; NO serves as mediator for development of secondary neurological disorders associated with stress such as anxiety and anxiety disorders. [REVIEW] PMID: 28061969
- nNOS mediates the human coronary vasodilator response to mental stress, predominantly through actions at the level of coronary resistance vessels. PMID: 28646032
- These findings highlight a key role of the TLR4-NOS1-AP1 signaling axis in regulating macrophage polarization PMID: 28013342
- Association between NOS1 and PTSD severity and stress was found. NOS1 was associated with resilience. PMID: 28465168
- Data show that metastasis associated 1 (MTA1) represses neuronal nitric oxide synthase (nNOS) expression upon oxygen glucose deprivation (OGD)-induced oxidative stress. PMID: 27603575
- Superoxide generation from NOS1 splice variants and its potential involvement in redox signal regulation has been described. PMID: 28126743
- expression of neuronal NOS heterodimers in insect cells, where we take advantage of an exogenous heme-triggered chaperone-assisted assembly process, provides an approximately 43% yield in heterodimeric NOS. PMID: 27487179
- NOS1 ex1f-VNTR is associated with anxiety-related traits. PMID: 26746182
- The NOS1 exon18 variants might play a role in the risk of Parkinson's disease (Meta-Analysis) PMID: 27749554
- nNOS gene variants contribute to OCD pathogenesis. PMID: 27739347
- Findings demonstrate that the upregulation of cardiac NOS1 is not accompanied by an increase in NOS activity; it is partially translocated to the sarcolemma in ischemic hearts with direct relationship between its protein levels and systolic ventricular function. These results indicate that NOS1 may be significant in the pathophysiology of human ischemic heart disease. PMID: 27041589
- The found of this study suggested that possible roles of NOS1 gene in working memory performance in ADHD patients PMID: 26233433
- NOS1 rs7977109 and rs693534 genotypes and allelic variants are not associated with the risk for migraine in Caucasian Spanish people PMID: 26283425
- These results of this study suggested that SNAP25 and NOS1 genotypes influence ADHD symptoms only in adults with ADHD. PMID: 26821215
- CoCl2 increased nNOS expression and NO production in human neuroblastoma SK-N-SH cells by increasing HIF-1a expression and binding to a a hypoxia response element in the nNos promoter. PMID: 26458913
- polymorphisms in the gene may be useful in identifying women at risk for osteoporosis. PMID: 25871004
- DLC1 binding to nNOS-calmodulin complex does not affect the electron transport from the reductase to the oxygenase domain. PMID: 26923072
- We conclude that DNM2 is a novel negative regulator of NO production in mouse collecting ducts. PMID: 26791826
- analysis of the interaction between nNOS and dystrophin repeats 16 and 17 PMID: 26378238
- the first structure of human neuronal nitric oxide syntahse PMID: 25286850
- This study first-time showed highest Red Blood Cell (RBC)-Nitric Oxide Synthase activation and nitric oxide production in old RBC. PMID: 25902315
- Results suggested a link between NOS1 gene polymorphism at rs3782206 and cognitive functions and their neural underpinnings at the right inferior frontal gyrus PMID: 25490993
- Tetrahydrobiopterin:dihydrobiopterin ratio is lower in tumor tissues and, as a consequence, NOS activity generates more peroxynitrite and superoxide anion than nitric oxide, resulting in important tumor growth-promoting and antiapoptotic signaling properties. PMID: 25724429
- Study found no significant differences either in the frequencies of the NOS1 rs7977109 and rs693534 genotypes or in the frequencies of the allelic variants of these SNPs in restless legs syndrome patients when compared with healthy controls PMID: 25300364
- Studied and determined the localisation of neuronal NOS (nNOS) in human airway epithelium. PMID: 25460324
- T allele of rs2293050 and A allele of rs2139733 in nNOS gene may contribute to increased susceptibility of LAA-caused ischemic stroke in Han Chinese PMID: 24668187
- Results suggest that NOS1 SNPs interact with exposure to economic and psychosocial stressors to alter individual's susceptibility to depression PMID: 24917196
- we discuss the idea that post-translational modifications of Ca2 + regulatory proteins via aberrant neuronal nitric oxide synthase (NOS1)-mediated nitroso-redox balance contribute to contractility defects in Heart failure PMID: 24801117
- 2-methoxyestradiol specifically affects neuronal nitric oxide synthase and augments 3-nitrotyrosine level leading to osteosarcoma and immortalized hippocampal cell death. PMID: 25170949
- Increased cellular expression of nNOS was accompanied by elevated NO generation in brains of heroin addicts and may have contributed to some of the known toxic effects of heroin. PMID: 23953641
- Results identified NOS1 as a novel nitric oxide target in human skeletal muscle controlled by activity driven auto-nitrosylation mechanisms. PMID: 24251120
- rADI not only reduced NO production but also caused cellular toxicity in nNOS-activated SH-SY5Y cells, suggesting a dual role for rADI in NOS-mediated neurotoxicity. PMID: 25126568
- DNA methylation of NOS1 plays role in atherogenesis through regulation of NO production. PMID: 24622112
- This review will focus on the role of Nitric Oxide Synthases (NOSes) the role they play in the pathogenesis of subarachnoid hemorrhage. PMID: 25366612
- The NOS1 rs41279104 CT genotype was associated with good responders in postoperative ED patients. PMID: 24897285
- Studied which NOS gene variants are most strongly associated with coronary heart disease (CHD) and hypertension and confirmed NOS1 as the most important NOS risk gene for CHD. PMID: 24713495
- Population genetic variability in Sardinia (Italy) shows a positive and highly significant correlation between mortality determined by malaria infection and alleles (TGGA)7 of NOS2, (AAAAG)2 and (ATTT)10 of adNOS1, and (AAACA)11 of adNOS3 genes. PMID: 24573959
- The resukts of this study demonistrated that the risk allele significantly decreases expression of NOS1 in the prefrontal cortex in patient with schizophrenia. PMID: 24220657
- Genetic or pharmacologic inhibition of NOS1 reduced the growth of CXCL14-expressing fibroblasts. PMID: 24710408
- The results showed that rs7308402 gene polymorphism of nNOS is related to ischemic stroke in Han Chinese of North China. PMID: 24082858
- A report on the reduction of NOS1 expression in the anterior cingulate cortex in depressive patients. PMID: 22989585
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亞細胞定位：Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine.
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蛋白家族：NOS family
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組織特異性：Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected
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