NLRC5 Antibody, FITC conjugated
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中文名稱：NLRC5兔多克隆抗體, FITC偶聯(lián)
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貨號：CSB-PA771457LC01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) NLRC5 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Caterpiller protein 16.1 antibody; CLR16.1 antibody; FLJ21709 antibody; FLJ39711 antibody; NLR family, CARD domain containing 5 antibody; NLR family, CARD-containing 5 antibody; NLR family, caspase recruitment domain-containing 5 antibody; NLRC5 antibody; NLRC5_HUMAN antibody; NOD-like receptor C5 antibody; NOD27 antibody; NOD4 antibody; Nucleotide-binding oligomerization domain protein 27 antibody; Nucleotide-binding oligomerization domain protein 4 antibody; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5 antibody; nucleotide-binding oligomerization domains 27 antibody; OTTHUMP00000164675 antibody; Protein Caterpiller 16.1 antibody; Protein NLRC5 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Protein NLRC5 protein (95-208AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.
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基因功能參考文獻(xiàn)：
- Genetic polymorphisms in NLRC5 may be used as prognostic markers of survival of colorectal cancer patients, as well as for survival in response to 5-FU treatment. PMID: 29762254
- knockdown of NLRC5 attenuates renal ischemia/reperfusion injury in vitro through the activation of PI3K/Akt signaling pathway. PMID: 29655162
- NLRC5 may act as a key mediator in renal fibroblast activation and fibrogenesis PMID: 29608899
- obtained 18 pair-wise interactions within and between the NLRC5 ad PD-L1 genes and 6 more when IFNGR variants were added PMID: 29408916
- Our study, for the first time, identified the possible involvement of a polymorphism within NLRC5 gene as a possible biomarker for periodontitis condition susceptibility among Italian individuals from genetic isolates. PMID: 28122660
- NLRC5 interacts with miR-34a.NLRC5 role in HPV16 persistence. PMID: 27423514
- These results demonstrate that NLRC5 promotes hepatocellular carcinoma progression via the AKT/VEGF-A signaling pathway PMID: 27338800
- NLRC5 not only positively correlates with the increase of beta-catenin but also coordinates the activation of downstream Wnt/beta-catenin signaling pathway, regulating cell proliferation, migration and invasion in hepatocellular carcinoma. PMID: 26975630
- silencing NLRC5 reduced extracellular matrix expression in keloid fibroblasts through inhibiting the TGF-beta1/Smad signaling pathway. PMID: 27525969
- CITA/NLRC5 and CIITA are transcriptional regulators that orchestrate the concerted expression of critical components in the MHC class I and class II pathways, respectively. [review] PMID: 27087581
- NLRC5 expression was significantly associated with the activation of CD8(+) cytotoxic T cells and patient survival in multiple cancer types. Thus, NLRC5 constitutes a novel prognostic biomarker and potential therapeutic target of cancers. PMID: 27162338
- NLRC5 regulates TGFB1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis. PMID: 26592197
- In a transformed cell line, NLRC5 plays a significant role in IL-6 and IL-1Beta secretion. PMID: 25820389
- NLRC5 function is shaped by reversible ubiquitination, which modulates the NF-kappaB activation switch PMID: 26620909
- RSV infection of lung epithelial cells induces expression of RIG-I, NLRC5, and subsequent upregulation of HLA-A, HLA-B and HLA-C. PMID: 25972545
- a novel role for NLRC5 in RIG-I-mediated antiviral host responses against influenza virus infection, distinguished from the role of NLRC5 in MHC class I gene regulation. PMID: 25404059
- This study presents a detailed functional study of the domains of NLRC5 revealing that the N-terminal domain of human NLRC5 has intrinsic transcriptional activity. PMID: 25127861
- Unusual structural features revealed by the solution NMR structure of the NLRC5 caspase recruitment domain. PMID: 24815518
- A model for full-length human NLRC5 was prepared and, besides the closed conformation of monomeric NLRC5, a heptameric platform was also modeled for the opened conformational NLRC5 monomers. PMID: 24044430
- rhinovirus ion channel protein 2B triggers NLRP3 and NLRC5 inflammasome activation and IL-1beta secretion in bronchial cells PMID: 23815151
- Expression of NLRC5 positively correlates with histocompatibility class I expression in human tissues. PMID: 22490867
- NLRC5 can cooperate with X1 box-binding transcription factor RFX and X2 box-binding transcription factor ATF1 in activation of histocompatibility class I promoter region. PMID: 22490869
- NLRC5 acts as a key transcriptional regulator of MHC I in lymphocytes and support an essential role for NLRs in directing not only innate but also adaptive immune responses. PMID: 22412192
- NLRC5-mediated MHC class I gene induction requires an intact nuclear localization signal and nuclear distribution of NLRC5. PMID: 22310711
- NLRC5 was proposed to function as a positive and as a negative regulator of IFN, NF-kappaB, AP-1 signaling and antiviral immunity. (Review) PMID: 22024701
- NLRC5 is a critical component of inflammasome-dependent interleukin (IL)-1beta secretion in response to a repertoire of stimuli that also activate NLRP3. PMID: 21191067
- function for NLRC5 in anti-viral innate immune responses PMID: 20538593
- NLRC5 is identified and characterized as a key regulator of proinflammatory pathways in immune cells. PMID: 20610642
- suggest that NLRC5 is a transcriptional regulator, orchestrating the concerted expression of critical components in the MHC class I pathway. PMID: 20639463
- Study identifies NLRC5 as a negative regulator that blocks two central components of the NF-kappaB and type I interferon signaling pathways and suggest an important role for NLRC5 in homeostatic control of innate immunity. PMID: 20434986
- NLRC5 may represent a molecular switch of interferon (IFN)-gamma activation sequence and IFN-specific response element signaling pathways contributing to antiviral defense mechanisms. PMID: 20061403
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亞細(xì)胞定位：Cytoplasm.
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蛋白家族：NLRP family
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組織特異性：Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate.
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