NISCH Antibody
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中文名稱：NISCH兔多克隆抗體
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貨號：CSB-PA015821DSR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA015821DSR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA015821DSR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) NISCH Polyclonal antibody
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Uniprot No.：
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基因名：NISCH
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別名：NISCH antibody; IRAS antibody; KIAA0975 antibody; Nischarin antibody; Imidazoline receptor 1 antibody; I-1 antibody; IR1 antibody; Imidazoline receptor antisera-selected protein antibody; hIRAS antibody; Imidazoline-1 receptor antibody; I1R antibody; Imidazoline-1 receptor candidate protein antibody; I-1 receptor candidate protein antibody; I1R candidate protein antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Nischarin protein (500-700AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension. Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons. Acts as a modulator of Rac-regulated signal transduction pathways. Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity. Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation. Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation. Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells. Inhibits lamellipodia formation, when overexpressed. Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.
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基因功能參考文獻：
- These experiments demonstrate an important role of Nischarin in regulating cell attachment, which adds to our understanding of the early events of the metastatic process in breast cancer. PMID: 29415725
- In the prefrontal cortex of long-term opiate/cocaine abusers, IRAS content was increased when compared to matched controls. PMID: 28461172
- IRAS is a new mu opioid receptor interacting protein that regulates agonist-induced trafficking of mu opioid receptor. PMID: 26363797
- The present data confirmed that Nishcharin might be a novel tumor suppressor and plays an important role in breast cancer cell apoptosis and metastasis, which can be used as a potential therapeutic target for breast cancer treatment. PMID: 28131840
- Data found that NISCH was significantly downregulated in ovarian neoplasm through its promotor silencing with hypermethylation and its expression was correlated with poor prognosis. PMID: 25724667
- Nischarin expression may therefore be used as a marker to predict the invasiveness and metastasis of primary breast cancer PMID: 25695373
- Tobacco smoke induces methylation changes in the NISCH gene promoter before any detectable cancer. PMID: 23503203
- unctional interaction between LKB1 and Nischarin to inhibit cell migration and breast tumor progression PMID: 23572524
- Imidazoline receptor 1 gene plays a role in the development of cardiac hypertrophy and ventirular remodeling. PMID: 22483786
- Nischarin reduces alpha5 integrin expression leading to reduction of FAK phosphorylation and Rac GTP loading, which in turn reduces tumor growth. NISCH also regulates PAK and LIMK signaling. PMID: 21917605
- Insulin receptor substrate 4 associates with the protein IRAS (IRAS protein) PMID: 11912194
- The heart possesses imidazoline I1-receptors that are up-regulated in the presence of hypertension or heart failure, which suggests their involvement in cardiovascular regulation. PMID: 12021582
- I(1)-receptors can abrogate the primary signaling cascade activated by NGF, most likely by increasing levels of a specific phosphatase to return dually phosphorylated ERK to its unphosphorylated state. PMID: 12865160
- hIRAS expression in PC12 cells resulted in protection against apoptosis PMID: 12868002
- Results suggest that IRAS may represent a previously unknown anti-apoptotic protein involved in the regulation of cell survival. PMID: 15028619
- Results describe three alternatively spliced transcripts of the human I(1)-imidazoline receptor candidate gene, IRAS. PMID: 15028621
- Results suggest that imidazoline-1 receptors (I(1)R) and alpha(2)-noradrenergic receptors (alpha(2)AR) may interact with each other. PMID: 15028622
- platelets lacked the 170-kD form of IRAS, but 33-kD and 85-kD bands were detectable and seemed to be possible fragments of full-length IRAS PMID: 15028623
- PX domain of imidazoline receptor antisera-selected protein(IRAS) is essential for association with phosphatidylinositol 3-phosphate-enriched endosomal membranes but is insufficient without coiled-coil domain PMID: 15475348
- The signaling pathway of IRAS in response to I1R agonists coupled with the activation of PC-PLC and its downstream signal transduction molecule, ERK. These findings are similar to those in the signaling pathways of native I1R. PMID: 16598778
- shows strong affinity to clonidine and regulates blood pressure. PMID: 18561481
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亞細胞定位：Cell membrane. Cytoplasm. Early endosome. Recycling endosome.
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組織特異性：Isoform 1, isoform 3 and isoform 4 are expressed in brain. Isoform 1 is expressed in endocrine tissues.
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數據庫鏈接：
