MUTYH Antibody

說明書

中文名稱：

MUTYH兔多克隆抗體
貨號：

CSB-PA029874
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA029874(MUTYH Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA029874(MUTYH Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: CSB-PA029874(MUTYH Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9UIF7
基因名：

MUTYH
別名：

A/G specific adenine DNA glycosylase antibody; A/G-specific adenine DNA glycosylase antibody; Adenine DNA glycosylase antibody; CYP2C antibody; hMYH antibody; MGC4416 antibody; MutY (E. coli) homolog antibody; MutY homolog (E. coli) antibody; MutY homolog antibody; MutY, E. coli, homolog of antibody; Mutyh antibody; MUTYH_HUMAN antibody; MYH antibody; rMYH antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Fusion protein of Human MUTYH
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:10000
WB	1:1000-1:5000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
基因功能參考文獻：
1. The MUTYH gene presents downregulation in the more advanced stages of colorectal cancer PMID: 29257843
2. MUTYH variants among Japanese colorectal polyposis patients. PMID: 29330641
3. Our results suggest that p.(Gly396Asp) in MUTYH, and potentially other mutations in additional members of the same DNA excision-repair pathway (such as the OGG1 gene) might be involved in driving the tumorigenesis leading to familial and sporadic small intestinal neuroendocrine tumors . PMID: 28634180
4. Knockdown of MYH in pancreatic cancer cells reduces tumor growth and sensitizes cells to antineoplastic agents. PMID: 27999205
5. Rheumatoid arthritis is associated with increased serum level of the MUTYH protein. PMID: 28173856
6. Inactivating MUTYH germline mutations are associated with high-grade midline gliomas. PMID: 26902849
7. this review focuses on multifaceted roles of MUTYH in the cell, both in the prevention of mutagenesis and tumorigenesis PMID: 28087410
8. Acetohexamide exerted this protective function by antagonizing expression of the DNA glycosylase, MUTYH. Together, our data reveal the existence of an NER-independent mechanism to remove UV-induced DNA damage and prevent cell death. PMID: 29149600
9. Data indicate that DNA glycosylases MYH, UNG2, MPG, NTH1, NEIL1, 2 and 3 on nascent DNA. PMID: 28575236
10. No biallelic mutation carriers for the MUTYH variants c.536A.G p.Tyr179Cys (Y179C) in exon 7 and c.1187G.A p.Gly396Asp (G396D) in exon 13 was found, after screening with a novel high resolution melt curve (HRM) analysis assay. PMID: 23805267
11. MUTYH p.Y179C mutation was associated with an increased risk of colorectal cancer among Egyptian patients rather than MUTYH p.G396D mutation. PMID: 27631816
12. The majority (18/23) of patients with Familial Adenomatous Polyposis and all of the patients with Attenuated Familial Adenomatous Polyposis with an Adrenal Lesion had a genetically proven syndrome.All of the patients with MUTYH-Associated Polyposis had a biallelic germline MUTYH mutation. PMID: 28891849
13. These results suggested that reduced MUTYH expression is associated with somatic mutation loads via a reduction in DNA repair capacity in prostate adenocarcinoma. PMID: 27253753
14. Authors identified 266 probands (91% Caucasians) with a MUTYH mutation (41 biallelic and 225 monoallelic) from the Colon Cancer Family Registry. Mutation status, sex, age and histories of cancer from their 1,903 first- and 3,255 second-degree relatives were analyzed using modified segregation analysis conditioned on the ascertainment criteria. PMID: 27194394
15. A high heterogeneity of MUTYH variants and a high rate of variants of unknown significance were identified in a cohort of Italian patients with suspected MUTYH-associated polyposis. Genotype-phenotype analysis suggests that the p.Glu480del variant is associated with a severe phenotype. PMID: 27829682
16. Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas. PMID: 28127763
17. report of the results of functional evaluation of nine missense-type MUTYH variant proteins in the Japanese population; findingssuggest that p.N238S and p.R247G are likely to be pathogenic alleles for MUTYH-associated polyposis PMID: 26694661
18. Case Report: MUTYH-associated polyposis with cutaneous sebaceous lesions. PMID: 27870730
19. The IVS10-2A>G MUTYH heterozygote variant might add to the risk of developing germline APC mutation negative colorectal adenomatous polyposis in Japanese patients. PMID: 26684191
20. MutY homolog Y165C and G382D mutations are not associated with cholangiocarinoma. PMID: 26881680
21. the age at onset of polyposis was significantly delayed for biallelic MUTYH mutation carriers as compared to patients with an APC mutation PMID: 26446593
22. A mutation in both a MUTYH and either a MLH1, MSH2 and PMS2 gene mutation is associated with colorectal cancer. PMID: 26202870
23. Expression of APC is decreased in mutation negative cases and this appears to be a promising indicator of FAP predisposition, while for MUTYH gene, mutation is associated to reduced mRNA expression. PMID: 26511139
24. MUTYH mutations are prevalent among Jews of North-African origin with colorectal adenomas.Increased risk for colorectal adenomas and cancer in mono-allelic MUTYH mutation carriers among among Jews of North-African origin. PMID: 25822476
25. We demonstrated that the rs3219463 and rs3219476 polymorphisms in RA patients from a Taiwan Chinese population were associated with disease susceptibility. These data indicate that the MUTYH gene may play a role in the progression of RA. PMID: 26273655
26. 47 MUTYH gene variants (site-directed mutagenesis) were generated, the proteins expressed in MutY-disrupted E. coli, and assessed their abilities to complement the functional deficiency in the E. coli by monitoring spontaneous mutation rates. PMID: 25820570
27. first study to show that SNPs of genes involved in DNA repair, may modulate the risk of Depressive Disorder. PMID: 26074017
28. The results of this study suggested that the MUTYH gene polymorphisms may play an important role in the etiology of Alzheimer's Disease. PMID: 25998844
29. adenine glycosylase activity, mismatch recognition properties and interaction with protein partners of MUTYH and 5 MAP variants were examined; P502L and R520Q had reduced affinity for PCNA; only Q324H was found to have reduced affinity for Hus1 PMID: 26377631
30. Results showed that AluYb8MUTYH variant was associated with high level of altered mtDNA in type 2 diabetes mellitus patients that may have resulted from inefficient base excision repair of MUTYH and a mechanism trigerred by elevated oxidative stress. PMID: 25829257
31. As well as MUTYH Tyr/Tyr and XPD Asp/Asn genotypes further increased the risk by 2.9. PMID: 25916209
32. Individuals with biallelic MUTYH mutations in MUTYH-associated polyposis are under-ascertained based on both genotype and phenotype under current standard testing practices. PMID: 24620956
33. Data suggest that detection of the c.34G>T KRAS transversion could imply biallelic germline mutY DNA glycosylase MUTYH mutation and lead to genetic counseling. PMID: 26056087
34. Biallelic MUTYH mutations impair the base excision repair process and can result in somatic mutational inactivation of both DNA mismatch repair alleles mimicking Lynch syndrome by displaying a DNA mismatch repair deficient tumor. PMID: 24518836
35. These data reveal that human Rad9 interacts directly with N-terminal region of human MYH. PMID: 25127721
36. Findings indicate that the type of MUTYH mutation can affect the extent of genome instability associated with MUTYH inactivation. PMID: 24569162
37. Monoallelic MUTYH hotspot mutations (p.G396D and p.Y179C) do not act as major genetic susceptibility factors causing a substantial CCA risk in the Caucasian population. PMID: 24420788
38. MUTYH-associated polyposis (MAP): evidence for the origin of the common European mutations p.Tyr179Cys and p.Gly396Asp by founder events. PMID: 23361220
39. The 3 heterozygosity variants of MYH gene in a Chinese population. PMID: 24377541
40. An association may exist between MUTYH and AE. PMID: 24377542
41. A heterozygous p.Arg19 * MUTYH variant and a heterozygous p.Arg109Trp MUTYH variant were detected in one patient each. PMID: 24799981
42. A proportion of unexplained LLS cases is caused by biallelic MUTYH mutations. PMID: 24953332
43. We observed a low frequency of MUTYH mutations among patients with multiple adenomatous and serrated polyps. PMID: 24470512
44. It is a component of a base excision repair system that protects the genomic information from oxidative damage. PMID: 23605219
45. Results show that MYH is a vital DNA repair enzyme that protects cells from oxidative DNA damage and is critical for a proper cellular response to DNA damage. PMID: 24315136
46. Report shows that the interdomain connector (IDC) of human MYH (hMYH) maintains interactions with hAPE1 and the human checkpoint clamp Rad9-Rad1-Hus1 (9-1-1) complex. PMID: 24209961
47. this study shows that MutYH is ubiquitinated in vitro and in vivo by the E3 ligase Mule between amino acids 475 and 535. PMID: 24443563
48. The rs3219489 SNP in the MUTYH gene was marginally significant in association with colorectal cancer susceptibility. [Meta-analysis] PMID: 24039736
49. Risks of CRC for carriers of monoallelic mutations in MUTYH with a first-degree relative with CRC are sufficiently high to warrant more intensive screening than for the general population. PMID: 24444654
50. the roles of the AluYb8MUTYH variant in impairing the mitochondrial base excision repair (mtBER) system PMID: 23936466
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相關疾?。?/div>
Familial adenomatous polyposis 2 (FAP2); Gastric cancer (GASC)
亞細胞定位：

Nucleus. Mitochondrion.
蛋白家族：

Nth/MutY family
數據庫鏈接：

HGNC: 7527

OMIM: 604933

KEGG: hsa:4595

STRING: 9606.ENSP00000361170

UniGene: Hs.271353

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