MLH3 Antibody

說明書

中文名稱：

MLH3兔多克隆抗體
貨號：

CSB-PA262280
規(guī)格：

￥2024
圖片：
Western blot analysis of extracts from K562 cells and HT-29 cells, using MLH3 antibody.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) MLH3 Polyclonal antibody
Uniprot No.：

Q9UHC1
基因名：

MLH3
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Synthesized peptide derived from internal of Human MLH3.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Probably involved in the repair of mismatches in DNA.
基因功能參考文獻(xiàn)：
1. The effects of chronic smoking on oral mucosa led to the methylation of genes MRE11A PMS2, XRCC1 and MLH3, but resulted in a reduction of gene expression of MRE11A and PMS2, which showed >/=50% methylation. These results provide evidence that smoking cause methylation and reduced expression of repair genes. PMID: 29775861
2. MLH3 germline variants are associated with colon cancer patients belonging to families with Lynch syndrome-associated brain tumors. PMID: 27401157
3. A polymorphism within the MLH3 gene is associated with oligozoospermia in Caucasian men of a certain area. PMID: 26520453
4. MutL homolog 3 (MLH3) promoter methylation was observed in 61% of oligoastrocytoma and 27% of astrocytoma. PMID: 26303387
5. Results indicate that CT(844)-CC(942) was associated with a high risk of cervical carcinoma and cervical intraepithelial neoplasia, and the CC(844)-CT(942) decreased the risk. PMID: 24759751
6. The experiments show recruitment and persistence of MutLgamma-heterodimers at UVA-induced DNA lesions. PMID: 23696135
7. the MutSbeta-MutLalpha interaction is mediated in part by residues ((L/I)SRFF) embedded within the MSH3 PCNA-binding motif PMID: 20154325
8. hMLH3 mRNA is present at low levels in numerous tissues but high levels in testis. hMLH3 functions in meiosis as well as hMSH2-hMSH3 repair processes & has little if any role in Hereditary Non-Polyposis Colorectal Cancer (HNPCC). PMID: 19483466
9. There is an association of polymorphism C85T in MSH5 or C2531T in MLH3 with male infertility, specifically azoospermia or severe oligozoospermia, and interaction between these MSH5 and MLH3 polymorphisms increased the risk of developing male infertility PMID: 19808033
10. Little evidence for involvement of MLH3 in colorectal cancer predisposition. PMID: 12800209
11. at pachynema, when chromosomes are fully paired, we find significant heterogeneity in the localization of the MutL homologs, MLH1 and MLH3, among human oocyte populations PMID: 15558497
12. The identification of inherited missense variants, somatic missense mutations (present in 3 of 57 tumors), and LOH in the tumor from a patient with a germ line missense change suggest a role for MLH3 in endometrial tumorigenesis. PMID: 16885347
13. Mutations of Mlh3 may work together with other genes in an accumulated manner and result in an increased risk of esophageal tumor PMID: 16981255
14. in absence of hPMS2, hMLH3 (hMutLgamma) is located in the nucleus, suggesting a conditional activity in MMR and supporting its role as a low-risk gene in hereditary non-polyposis colorectal cancer PMID: 17203173
15. Two simultaneous hMLH3 variants might predispose to spermatogenic arrest. PMID: 17482610
16. results suggest that the endonuclease activity of MutLalpha is important not only in MMR-dependent mutation avoidance but also for recombination and damage response functions PMID: 17567544
17. MLH3 and EXO1 alterations in familial colorectal cancer patients not fulfilling Amsterdam criteria. PMID: 17656264
18. To assess the significance of the inherited sequence variations in MLH3, we functionally characterized seven missense mutations PMID: 18521850
19. Mlh3 nullizygosity significantly increased Apc frameshift mutations and tumor multiplicity. PMID: 18551179
20. the different biochemical assays yielded no evidence that the eight MLH3 unclassified variants (missense mutations) tested are the cause of hereditary colorectal cancer, including Lynch syndrome PMID: 19156873
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相關(guān)疾?。?/div>
Hereditary non-polyposis colorectal cancer 7 (HNPCC7); Colorectal cancer (CRC)
亞細(xì)胞定位：

Nucleus.
蛋白家族：

DNA mismatch repair MutL/HexB family
組織特異性：

Ubiquitous.
數(shù)據(jù)庫鏈接：

HGNC: 7128

OMIM: 114500

KEGG: hsa:27030

STRING: 9606.ENSP00000348020

UniGene: Hs.436650

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