MEN1 Antibody

說(shuō)明書

中文名稱：

MEN1兔多克隆抗體
貨號(hào)：

CSB-PA003227
規(guī)格：

￥1090
圖片：
Western Blot analysis of HuvEc cells using Menin Polyclonal Antibody

Western Blot analysis of A549 cells using Menin Polyclonal Antibody
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

O00255
基因名：

MEN1
別名：

MEA 1 antibody; MEA1 antibody; MEN 1 antibody; Men1 antibody; MEN1_HUMAN antibody; Menin antibody; Multiple Endocrine Adenomatosis 1 antibody; Multiple Endocrine Neoplasia 1 antibody; SCG 2 antibody; SCG2 antibody; Suppressor Candidate Gene 2 antibody; Wermer syndrome antibody; ZES antibody; Zollinger Ellison Syndrome antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human Menin.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB, IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair.
基因功能參考文獻(xiàn)：
1. Menin functions as an oncogenic regulatory factor that is critical for MYC-mediated gene transcription. PMID: 28474697
2. This novel study reveals evidence supporting a possible association between altered MEN1 promoter methylation and clinical severity of disease PMID: 30149991
3. De novo mutation in MEN1 is not associated with parental somatic mosaicism.( PMID: 27799361
4. Results revealed that the expression level of menin was lower in lung cancer. Its expression is regulated by miR24 which directly targets menin and significantly inhibit its activity, thereby promoting the growth and metastasis of lung cancer cells. PMID: 29565463
5. A case of dorsal pancreatic hemi-agenesis is reported in a heterozygous carrier of a novel MEN1 variant. PMID: 29174091
6. A missense variant in aryl hydrocarbon receptor-interacting protein (AIP) gene and a truncating mutation in multiple endocrine neoplasia I protein (MEN1) gene were both detected in the proband and his father, showing limited co-segregation with phenotype. PMID: 29848728
7. menin is regulated by extracellular signaling factors and has a role in nuclear receptor activation and hepatobiliary pathology in various hepatic cell types [review] PMID: 28485270
8. Each of these autosomal dominant syndromes results from a specific germline mutation in unique genes: MEN1 is due to pathogenic MEN1 variants (11q13), MEN2A and MEN2B are due to pathogenic RET variants (10q11.21), MEN4 is due to pathogenic CDKN1B variants (12p13.1), and the HPT-JT syndrome is due to pathogenic CDC73 variants (1q25). PMID: 28674121
9. Menin deficiency is the consequence of a MEN1 mutation in most menin-negative primary hyperparathyroidism tissues PMID: 28597079
10. Data demonstrate an essential role for MLL1 and menin in mediating tumor maintenance and posterior HOXD gene activation in Ewing sarcoma. PMID: 27888797
11. Data suggest that a novel germline missense mutation in MEN1 (p.Gly42Val) accounts for type 1 multiple endocrine neoplasia in a family; this mutation was found in the patient and his mother. [CASE REPORT] PMID: 29066490
12. Our study provides important insights into the role of menin in DNA methylation and its impact on the pathogenesis of Multiple endocrine neoplasia type 1 syndrome tumor development. PMID: 26871472
13. MEN1 exerts an anti-proliferative function by regulating a distinct expression signature. PMID: 28273452
14. expression increased in late-stage primary sclerosing cholangitis PMID: 28602220
15. The results provide novel molecular insights into the tumor suppressor activity of menin, which is partly mediated by proteasomal degradation of beta-catenin and inhibition of Wnt/beta-catenin signaling. PMID: 28782520
16. knockdown of RPA2 promoted formation of the menin-p65 complex and repressed the expression of NF-kappaB-mediated genes. RPA2 expression was induced via an E2F1-dependent mechanism in MCF7 and MDA-MB-231 cells treated with NF-kappaB activators, TNF-alpha or lipopolysaccharide (LPS). PMID: 28007956
17. Loss of Menin is an early event in pancreatic neuroendocrine tumorigenesis and that ATRX/DAXX loss and alternative lengthening of telomeres are relatively late events. PMID: 27342911
18. The lack of somatic CDKN1B mutations in our samples points to a rare involvement in parathyroid adenomas, despite the frequent loss of nuclear p27 expression. MEN1 biallelic inactivation seems to be directly related to down-regulation of p27 expression through the inhibition of CDKN1B gene transcription. PMID: 27038812
19. This result shows a novel mechanism whereby menin, a RNA-binding protein, facilitates the processing of its specific miRNA by regulating the dynamics of the menin-miR-24 Gene Regulatory Network at the level of pri-miRNA processing. PMID: 27098433
20. findings reveal a previously unappreciated cross-talk between two crucial tumor suppressor genes, MEN1 and DAXX, thought to work by independent pathways PMID: 27872097
21. Multiple endocrine neoplasia type 1-related primary hyperparathyroidism patients experienced more common kidney complications but less skeletal issues, and a milder biochemical manifestation compared with SHPT patients. MEN1 mutation detection rate was 79.4% and 9 of the identified mutations were novel. PMID: 27846313
22. miR-24-dependent expression of menin may be important in the regulation of nonmalignant and cholangiocarcinoma proliferation. PMID: 28087162
23. rs2959656, a nonsynonymous variant in MEN1, is associated with the development of clinically active pituitary adenoma. PMID: 27185868
24. Study acts as a further supplement of the genetic features of neuroendocrine tumors. Somatic mutations of three potential tumor-related genes (HRAS, PAK1 and MEN1) might contribute to the tumorigenesis of thymic neuroendocrine tumors with EAS. PMID: 27913610
25. The results and clinical course of disease in this case indicate the potential role of menin in the development of non-endocrine or atypical-endocrine tumors in MEN1 patients. PMID: 26732163
26. cellular staining for menin also reveals the distribution of menin in the cell membrane and the punctate-like cell organelles PMID: 26560942
27. study to evaluate frequency of Multiple Endocrine Neoplasia type 1 (MEN1) in patients with pituitary adenoma and to perform genetic analysis and familial screening of those with MEN1; genetic analysis showed MEN1 mutations in 4 index cases: IVS4+1 G>A, IVS3-6 C>T, c.1547insC and a new D180A mutation PMID: 23334809
28. Study reports the coexistence of a germline intronic heterozygote variation at the MEN1 gene (IVS4+1G>T) and a germline mutation of exon 11 of RET proto-oncogene (K666M) in a large Italian family and describes clinical manifestations in the carriers. PMID: 21678021
29. novel MEN1 c.8251G>A mutation in a family with multiple endocrine neoplasia type 1 PMID: 26239674
30. progenitors. Our findings define SON as a fine-tuner of the MLL-menin interaction and reveal short SON overexpression as a marker indicating aberrant transcriptional initiation in leukemia. PMID: 26990989
31. interaction between menin and Dnmt1 reversibly regulates pancreatic cancer cell growth downstream of Hedgehog pathways with complex mutual modulation networks. PMID: 26454216
32. Molecular analysis of sporadic insulinoma revealed presence of three novel exonic mutations, two novel intronic variations, three reported exon SNPs, and one intronic SNP (rs669976). PMID: 26307114
33. Data show that menin, encoded by the MEN1 gene, inhibits the transcriptional activity of nuclear receptor liver X receptor alpha (LXRalpha). PMID: 25962847
34. While there appears be a modest link between MEN1 and breast cancer, causality has not so far been demonstrated. PMID: 25279812
35. Conditional knockout of beta-catenin suppresses the tumorigenesis and growth of Men1-deficient pancreatic neuroendocrine tumors. PMID: 25517963
36. miR-17 could inhibit protein levels of Menin through targeting its 3'-untranslated region PMID: 25753880
37. hyper-expression of the menin protein correlates closely with the poor prognosis of hepatocellular carcinoma patients PMID: 24845612
38. Mutations of MEN1 gene in a subset of Hurthle cell tumors point to a potential role for this protein and its associated pathways in thyroid tumorigenesis. PMID: 25625803
39. Menin expression is higher in castration-resistant prostate cancer than in both hormone-naive prostate cancer and benign prostate tissue, and high menin expression correlates with poor overall survival PMID: 25822367
40. data raise the question of a potential pathogenicity of the p.Ala541Thr missense variant of menin that commonly occurs within the general population PMID: 24997771
41. MEN1 patients with MEN1 mutations leading to CHES1-loss of interaction have a higher risk of malignant pancreatic neuroendocrine tumors with an aggressive course of disease and disease-related death. PMID: 25210877
42. miR-421 may promote neuroblastoma cell growth and motility partially by targeting menin PMID: 25012242
43. The p27 tumor suppressor gene CDKN1B acts as a disease modifier for the multiple endocrine neoplasia (MEN)1 syndrome associated with MEN1 germline mutations. PMID: 24920291
44. Our observations indicate that MEN1 mutations are involved in human breast carcinogenesis. PMID: 25099597
45. Loss of MENIN expression is associated with insulinoma. PMID: 24157940
46. a novel mechanism whereby menin suppresses cell proliferation, at least partly by promoting the processing of certain miRNAs, including let-7a, leading to suppression of Irs2 expression and insulin signaling. PMID: 24563463
47. presented a case of MEN 1 from its early stage and followed the progression PMID: 24302194
48. Whole exome capture and sequencing led to the discovery of a missense mutation in the MEN1 gene in familial hyperparathyroidism. PMID: 24074368
49. Thirteen percent of pulmonary carcinoids harbor MEN1 mutation associated with reduced mRNA expression and poor prognosis PMID: 24276465
50. role of MEN1 mutation in pituitary carcinomas PMID: 23905891
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相關(guān)疾病：

Familial multiple endocrine neoplasia type I (MEN1)
亞細(xì)胞定位：

Nucleus. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation.
組織特異性：

Ubiquitous.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 7010

OMIM: 131100

KEGG: hsa:4221

STRING: 9606.ENSP00000337088

UniGene: Hs.423348

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