MEN1 Recombinant Monoclonal Antibody
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中文名稱：MEN1重組抗體
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貨號：CSB-RA242999A0HU
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規格：￥1320
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圖片：
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Western Blot
Positive WB detected in: PC-3 whole cell lysate, MCF-7 whole cell lysate, 293 whole cell lysate
All lanes: MEN1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 69, 68, 64 kDa
Observed band size: 75 kDa
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其他：
產品詳情
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產品描述：CSB-RA242999A0HU MEN1重組單克隆抗體是針對menin蛋白研發的高特異性檢測工具，該蛋白作為MEN1基因編碼產物，在轉錄調控、表觀遺傳修飾及腫瘤抑制中發揮關鍵作用，其功能異常與多發性內分泌腺瘤綜合征1型及胰腺神經內分泌腫瘤密切相關。本抗體經多種實驗平臺嚴格驗證，在ELISA和蛋白質印跡（WB）檢測中展現優異性能，推薦WB工作濃度為1:500至1:5000，可精準識別內源性menin蛋白，適用于腫瘤發生機制研究、蛋白質相互作用分析及基因表達調控實驗等科研領域。通過高純度重組抗原免疫制備的特異性抗體，在細胞裂解物、組織樣本等多種實驗體系中均表現出低背景和高靈敏度特性，為探究腫瘤相關信號通路、構建疾病分子網絡及開發新型生物標志物提供可靠工具，尤其適用于內分泌系統腫瘤基礎研究、疾病模型驗證及分子病理學探索等前沿科研方向。
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Uniprot No.：
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基因名：
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別名：Menin, MEN1, SCG2
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反應種屬：Human
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免疫原：A synthesized peptide derived from human Menin
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號：8G11
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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產品提供形式：Liquid
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應用范圍：ELISA, WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair.
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基因功能參考文獻：
- Menin functions as an oncogenic regulatory factor that is critical for MYC-mediated gene transcription. PMID: 28474697
- This novel study reveals evidence supporting a possible association between altered MEN1 promoter methylation and clinical severity of disease PMID: 30149991
- De novo mutation in MEN1 is not associated with parental somatic mosaicism.( PMID: 27799361
- Results revealed that the expression level of menin was lower in lung cancer. Its expression is regulated by miR24 which directly targets menin and significantly inhibit its activity, thereby promoting the growth and metastasis of lung cancer cells. PMID: 29565463
- A case of dorsal pancreatic hemi-agenesis is reported in a heterozygous carrier of a novel MEN1 variant. PMID: 29174091
- A missense variant in aryl hydrocarbon receptor-interacting protein (AIP) gene and a truncating mutation in multiple endocrine neoplasia I protein (MEN1) gene were both detected in the proband and his father, showing limited co-segregation with phenotype. PMID: 29848728
- menin is regulated by extracellular signaling factors and has a role in nuclear receptor activation and hepatobiliary pathology in various hepatic cell types [review] PMID: 28485270
- Each of these autosomal dominant syndromes results from a specific germline mutation in unique genes: MEN1 is due to pathogenic MEN1 variants (11q13), MEN2A and MEN2B are due to pathogenic RET variants (10q11.21), MEN4 is due to pathogenic CDKN1B variants (12p13.1), and the HPT-JT syndrome is due to pathogenic CDC73 variants (1q25). PMID: 28674121
- Menin deficiency is the consequence of a MEN1 mutation in most menin-negative primary hyperparathyroidism tissues PMID: 28597079
- Data demonstrate an essential role for MLL1 and menin in mediating tumor maintenance and posterior HOXD gene activation in Ewing sarcoma. PMID: 27888797
- Data suggest that a novel germline missense mutation in MEN1 (p.Gly42Val) accounts for type 1 multiple endocrine neoplasia in a family; this mutation was found in the patient and his mother. [CASE REPORT] PMID: 29066490
- Our study provides important insights into the role of menin in DNA methylation and its impact on the pathogenesis of Multiple endocrine neoplasia type 1 syndrome tumor development. PMID: 26871472
- MEN1 exerts an anti-proliferative function by regulating a distinct expression signature. PMID: 28273452
- expression increased in late-stage primary sclerosing cholangitis PMID: 28602220
- The results provide novel molecular insights into the tumor suppressor activity of menin, which is partly mediated by proteasomal degradation of beta-catenin and inhibition of Wnt/beta-catenin signaling. PMID: 28782520
- knockdown of RPA2 promoted formation of the menin-p65 complex and repressed the expression of NF-kappaB-mediated genes. RPA2 expression was induced via an E2F1-dependent mechanism in MCF7 and MDA-MB-231 cells treated with NF-kappaB activators, TNF-alpha or lipopolysaccharide (LPS). PMID: 28007956
- Loss of Menin is an early event in pancreatic neuroendocrine tumorigenesis and that ATRX/DAXX loss and alternative lengthening of telomeres are relatively late events. PMID: 27342911
- The lack of somatic CDKN1B mutations in our samples points to a rare involvement in parathyroid adenomas, despite the frequent loss of nuclear p27 expression. MEN1 biallelic inactivation seems to be directly related to down-regulation of p27 expression through the inhibition of CDKN1B gene transcription. PMID: 27038812
- This result shows a novel mechanism whereby menin, a RNA-binding protein, facilitates the processing of its specific miRNA by regulating the dynamics of the menin-miR-24 Gene Regulatory Network at the level of pri-miRNA processing. PMID: 27098433
- findings reveal a previously unappreciated cross-talk between two crucial tumor suppressor genes, MEN1 and DAXX, thought to work by independent pathways PMID: 27872097
- Multiple endocrine neoplasia type 1-related primary hyperparathyroidism patients experienced more common kidney complications but less skeletal issues, and a milder biochemical manifestation compared with SHPT patients. MEN1 mutation detection rate was 79.4% and 9 of the identified mutations were novel. PMID: 27846313
- miR-24-dependent expression of menin may be important in the regulation of nonmalignant and cholangiocarcinoma proliferation. PMID: 28087162
- rs2959656, a nonsynonymous variant in MEN1, is associated with the development of clinically active pituitary adenoma. PMID: 27185868
- Study acts as a further supplement of the genetic features of neuroendocrine tumors. Somatic mutations of three potential tumor-related genes (HRAS, PAK1 and MEN1) might contribute to the tumorigenesis of thymic neuroendocrine tumors with EAS. PMID: 27913610
- The results and clinical course of disease in this case indicate the potential role of menin in the development of non-endocrine or atypical-endocrine tumors in MEN1 patients. PMID: 26732163
- cellular staining for menin also reveals the distribution of menin in the cell membrane and the punctate-like cell organelles PMID: 26560942
- study to evaluate frequency of Multiple Endocrine Neoplasia type 1 (MEN1) in patients with pituitary adenoma and to perform genetic analysis and familial screening of those with MEN1; genetic analysis showed MEN1 mutations in 4 index cases: IVS4+1 G>A, IVS3-6 C>T, c.1547insC and a new D180A mutation PMID: 23334809
- Study reports the coexistence of a germline intronic heterozygote variation at the MEN1 gene (IVS4+1G>T) and a germline mutation of exon 11 of RET proto-oncogene (K666M) in a large Italian family and describes clinical manifestations in the carriers. PMID: 21678021
- novel MEN1 c.8251G>A mutation in a family with multiple endocrine neoplasia type 1 PMID: 26239674
- progenitors. Our findings define SON as a fine-tuner of the MLL-menin interaction and reveal short SON overexpression as a marker indicating aberrant transcriptional initiation in leukemia. PMID: 26990989
- interaction between menin and Dnmt1 reversibly regulates pancreatic cancer cell growth downstream of Hedgehog pathways with complex mutual modulation networks. PMID: 26454216
- Molecular analysis of sporadic insulinoma revealed presence of three novel exonic mutations, two novel intronic variations, three reported exon SNPs, and one intronic SNP (rs669976). PMID: 26307114
- Data show that menin, encoded by the MEN1 gene, inhibits the transcriptional activity of nuclear receptor liver X receptor alpha (LXRalpha). PMID: 25962847
- While there appears be a modest link between MEN1 and breast cancer, causality has not so far been demonstrated. PMID: 25279812
- Conditional knockout of beta-catenin suppresses the tumorigenesis and growth of Men1-deficient pancreatic neuroendocrine tumors. PMID: 25517963
- miR-17 could inhibit protein levels of Menin through targeting its 3'-untranslated region PMID: 25753880
- hyper-expression of the menin protein correlates closely with the poor prognosis of hepatocellular carcinoma patients PMID: 24845612
- Mutations of MEN1 gene in a subset of Hurthle cell tumors point to a potential role for this protein and its associated pathways in thyroid tumorigenesis. PMID: 25625803
- Menin expression is higher in castration-resistant prostate cancer than in both hormone-naive prostate cancer and benign prostate tissue, and high menin expression correlates with poor overall survival PMID: 25822367
- data raise the question of a potential pathogenicity of the p.Ala541Thr missense variant of menin that commonly occurs within the general population PMID: 24997771
- MEN1 patients with MEN1 mutations leading to CHES1-loss of interaction have a higher risk of malignant pancreatic neuroendocrine tumors with an aggressive course of disease and disease-related death. PMID: 25210877
- miR-421 may promote neuroblastoma cell growth and motility partially by targeting menin PMID: 25012242
- The p27 tumor suppressor gene CDKN1B acts as a disease modifier for the multiple endocrine neoplasia (MEN)1 syndrome associated with MEN1 germline mutations. PMID: 24920291
- Our observations indicate that MEN1 mutations are involved in human breast carcinogenesis. PMID: 25099597
- Loss of MENIN expression is associated with insulinoma. PMID: 24157940
- a novel mechanism whereby menin suppresses cell proliferation, at least partly by promoting the processing of certain miRNAs, including let-7a, leading to suppression of Irs2 expression and insulin signaling. PMID: 24563463
- presented a case of MEN 1 from its early stage and followed the progression PMID: 24302194
- Whole exome capture and sequencing led to the discovery of a missense mutation in the MEN1 gene in familial hyperparathyroidism. PMID: 24074368
- Thirteen percent of pulmonary carcinoids harbor MEN1 mutation associated with reduced mRNA expression and poor prognosis PMID: 24276465
- role of MEN1 mutation in pituitary carcinomas PMID: 23905891
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相關疾病：Familial multiple endocrine neoplasia type I (MEN1)
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亞細胞定位：Nucleus. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation.
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組織特異性：Ubiquitous.
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數據庫鏈接：
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