MAP4K4 Antibody, HRP conjugated

說明書

中文名稱：

MAP4K4兔多克隆抗體, HRP偶聯(lián)
貨號：

CSB-PA013439LB01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) MAP4K4 Polyclonal antibody
Uniprot No.：

O95819
基因名：

MAP4K4
別名：

FLH21957 antibody; FLJ10410 antibody; FLJ20373 antibody; FLJ90111 antibody; Hepatocyte progenitor kinase like/germinal center kinase like kinase antibody; HGK antibody; HPK/GCK like kinase antibody; HPK/GCK like kinase HGK antibody; HPK/GCK-like kinase HGK antibody; KIAA0687 antibody; M4K4_HUMAN antibody; MAP4K4 antibody; MAPK/ERK kinase kinase kinase 4 antibody; MEK kinase kinase 4 antibody; MEKKK 4 antibody; MEKKK4 antibody; Mitogen activated protein kinase kinase kinase kinase 4 antibody; Mitogen-activated protein kinase kinase kinase kinase 4 antibody; Nck interacting kinase antibody; Nck-interacting kinase antibody; NIK antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Mitogen-activated protein kinase kinase kinase kinase 4 protein (866-1104AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.
基因功能參考文獻：
1. an anti-cancer effect of microRNA-141 on breast cancer by cytotoxic CD4+ T cells through MAP4K4 expression. PMID: 29620289
2. the close proximity between AcSDKP and FGFR1 was essential for the suppression of TGFbeta/smad signaling and EndMT associated with MAP4K4 phosphorylation (P-MAP4K4) in endothelial cells. PMID: 28771231
3. RBM4-SRSF3-MAP4K4 constitutes a novel mechanism for manipulating the metastasis of colorectal cancer cells through the JNK1 signaling pathway. PMID: 29138007
4. these findings identify MAP4K4 as a novel MAPK/ERK pathway regulator in lung adenocarcinoma that is required for lung adenocarcinoma maintenance. PMID: 28306189
5. This report identifies HGK methylation/downregulation in T cells as a potential biomarker for non-obese type 2 diabetes PMID: 26918832
6. Results reveal that endothelial Map4k4 is critical for lymphatic vascular development by regulating endothelial cells (EC)quiescence and lymphatic EC fate. PMID: 27044870
7. of the five variants, SNP rs2236935T/C was significantly associated with type 2 diabetes mellitus (T2DM) in this study population; conclude that MAP4K4 gene is associated with T2DM in a Chinese Han population, and MAP4K4 gene variants may contribute to the risk toward the development of T2DM PMID: 27174326
8. Interactions between MAP4K4 gene variants and environmental factors may contribute to MAP4K4 attenuation in T cells, leading to non-obese T2D. PMID: 28061846
9. MAP4K4 promotes the epithelial-mesenchymal transition and invasiveness of hepatocellular carcinoma cells PMID: 27010469
10. miR-194 regulated the progression of hepatocellular carcinoma through directly inhibiting the expression of MAP4K4 PMID: 26722431
11. The results of the present study suggested that inhibition of MAP4K4 may be a therapeutic strategy for gastric cancer. PMID: 26549737
12. loss of MAP4K4 function suppressed pathological angiogenesis in disease models, identifying MAP4K4 as a potential therapeutic target PMID: 25799996
13. that MAP4K4, a known mediator of inflammation, is involved in KS aetiology by regulating KSHV lytic reactivation PMID: 24244164
14. results reveal a key target of SOX2 expression and highlight the unexpected context-dependent role for MAP4K4, a pluripotent activator of several mitogen-activated protein kinase pathways, in regulating tumor cell survival. PMID: 24233838
15. TRAF1.NIK is a central complex linking canonical and non-canonical pathways by disrupting the TRAF2-cIAP2 ubiquitin ligase complex PMID: 23543740
16. Common polymorphisms in MAP4K4 are associated with insulin resistance and beta-cell dysfunction, possibly via this gene's role in inflammatory signaling. PMID: 23094072
17. Elevated MAP4K4 expression is closely associated with lung adenocarcinoma progression with independent prognostic value in predicting overall survival for patients with lung adenocarcinoma. PMID: 22824148
18. MAP4K4 overexpression is an independent predictor of poor prognosis of Hepatocellular Carcinoma patients, and inhibition of its expression might be of therapeutic significance PMID: 21196414
19. Data show that down-regulation of hepatocyte progenitor kinase-like kinase (HGK) can obviously inhibit the migration and invasion of HepG2 cells in vitro, and suggest that HGK may be a new therapeutic target for treatment of hepatocellular carcinoma. PMID: 20857524
20. interaction with GBP3 PMID: 12387898
21. The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. PMID: 12612079
22. MAP4K4 is a putative effector of Rap2, a Ras family small GTP-binding protein, mediating the activation of JNK by Rap2 PMID: 14966141
23. studies of the promigratory role of MAP4K4 showed that the knockdown of this transcript inhibited the migration of multiple carcinoma cell lines, indicating a broad role in cell motility PMID: 16537454
24. MAP4K4 silencing prevents TNFa-induced insulin resistance in human skeletal muscle and restores appropriate signaling inputs to enhance glucose uptake PMID: 17227768
25. MAP4K4 expression significantly correlated with overall and recurrence-free survival (P=0.025 and 0.004) independent of age, tumor size, differentiation, and stage. PMID: 18981001
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亞細胞定位：

Cytoplasm.
蛋白家族：

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
組織特異性：

Widely expressed. Isoform 5 is abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta.
數(shù)據(jù)庫鏈接：

HGNC: 6866

OMIM: 604666

KEGG: hsa:9448

STRING: 9606.ENSP00000314363

UniGene: Hs.701013

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