MALT1 Antibody

說明書

中文名稱：

MALT1兔多克隆抗體
貨號：

CSB-PA006741
規格：

￥1090
圖片：
Western Blot analysis of HUVEC cells using MALT1 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9UDY8
基因名：

MALT1
別名：

Caspase like protein antibody; DKFZp434L132 antibody; IMD12 antibody; MALT 1 antibody; MALT associated translocation antibody; MALT lymphoma associated translocation antibody; MALT lymphoma-associated translocation antibody; Malt1 antibody; MALT1 paracaspase antibody; MALT1_HUMAN antibody; MLT 1 antibody; MLT antibody; MLT1 antibody; Mucosa associated lymphoid tissue lymphoma translocation gene 1 antibody; Mucosa associated lymphoid tissue lymphoma translocation protein 1 antibody; Mucosa-associated lymphoid tissue lymphoma translocation protein 1 antibody; Paracaspase antibody; Paracaspase-1 antibody; PCASP1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human MALT1.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation. Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity.
基因功能參考文獻：
1. Cellular metabolism constrains innate immune responses in preterm infants due to perturbations in the expression of PPARgamma, MALT1, DDIT4, and most of the cytokines. PMID: 30446641
2. this first report show that MALT1 integrates several T-cell activation pathways and indirectly controls gamma-chain receptor dependent survival, to impact on T-cell expansion PMID: 29359407
3. These findings suggested that cleavage at R781 of MALT1 played a role in the survival of activated B-cell like diffuse large B-cell lymphoma cells. PMID: 29953499
4. MALT1 and TRAF6 cooperatively interact with CARMA1-BCL10 filaments and form CARMA1-BCL10-MALT1-TRAF6 signalosome. PMID: 29382759
5. The results suggest that the involvement of MALT1 in DNA damage-induced NF-kappaB is through the recruitment of TRAF6. PMID: 28717989
6. A missense mutation in mucosa-associated lymphoid tissue lymphoma translocation 1 gene (MALT1) was identified in a family with siblings with IPEX-Like Syndrome. MALT1 deficiency should now be considered as a possible cause of IPEX-like syndrome associated with immunodeficiency. PMID: 27253662
7. Thrombin-mediated MALT1 protease activation triggers acute disruption of endothelial barrier integrity via CYLD cleavage. PMID: 27681433
8. Authors utilized transcriptomic data and experimental evidences to prove that miR-181d was a novel regulator of NFkappaB signaling pathway by directly repressing MALT1, leading to induced PN markers and reduced MES genes. PMID: 28286260
9. Taken together, this present study indicates that miR-649 promotes herpes simplex virus type 1 replication through regulation of the MALT1-mediated antiviral signaling pathway and suggests a promising target for antiviral therapies. PMID: 27813118
10. These results demonstrate a key role for the proteolytic activity of MALT1 in PEL, and provide a rationale for the pharmacological targeting of MALT1 in PEL therapy. PMID: 27538487
11. MALT1 deficiency or pharmacological inhibition of MALT1 catalytic activity inhibits pathogenic mutant CARD14-induced cytokine and chemokine expression in human primary keratinocytes. PMID: 27113748
12. CARD14/MALT1-mediated signaling in keratinocytes has a role in psoriasis [review] PMID: 27939769
13. Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-kappaB activation PMID: 27071417
14. Studies indicate that t(11;18)(q21;q21) translocation involves MALT1 (MALT lymphoma translocation protein 1) gene. PMID: 26386283
15. Targeting MALT1 proteolytic activity in autoimmune disease and B-cell lymphoma might not be a successful strategy. (Review) PMID: 26787500
16. Data show that Bruton tyrosine kinase (BTK)inhibitor Ibrutinib augments MALT lymphoma associated translocation protein (MALT1) inhibition by S-Mepazine in CD79 antigen mutant activated B cell-subtype (ABC) of diffuse large B cell lymphoma (DLBCL). PMID: 26540570
17. TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation. PMID: 27068814
18. MALT1 protease activity has a central role in keratinocyte immunity PMID: 26767426
19. Data show that caspase recruitment domain-containing protein 11/B-cell CLL/lymphoma 10/mucosa-associated lymphoid tissue lymphoma translocation gene 1 signaling drives lymphoproliferation through NF-kappa B and c-Jun N-terminal kinase activation. PMID: 26668357
20. MALT1-dependent NF-kappaB activation is crucial for the development of EGFR-associated solid-tumor progression PMID: 25982276
21. Backbone Assignment of the MALT1 Paracaspase by Solution NMR. PMID: 26788853
22. The MALT1-mediated HOIL-1 cleavage provides a gain-of-function mechanism that is involved in the negative feedback regulation of NF-kappaB signaling. PMID: 26573773
23. The MALT1 is a key player in the activation of the NF-kappa B upon antigen receptor stimulation and lymphocyte activation. PMID: 26716947
24. Comparative analysis of the active site suggests that paracaspases constitute one of the several subclasses of metacaspases that have evolved several times independently. PMID: 26377317
25. An overview of the present understanding of MALT1's function is presented. [review] PMID: 26507244
26. By regulating linear ubiquitination, MALT1 is both a positive and negative pleiotropic regulator of the human canonical NF-kappaB pathway. PMID: 26525107
27. MALT1 uses multiple strategies to ensure NF-kappaB activation and target gene expression. (Review) PMID: 25996250
28. data demonstrate that MALT1 ubiquitination is critical for the engagement of CBM and IKK complexes, thereby directing platelet signals to the NF-kappaB pathway. PMID: 25748427
29. API2-MALT1 induces paracaspase-mediated cleavage of the tumour suppressor protein LIMA1. PMID: 25569716
30. The strongest hypermethylation signal in type 2 diabetes mellitus is in the promoter of the MALT1 gene, involved in insulin and glycemic pathways, and related to taurocholate levels in blood. PMID: 25502755
31. Absence of the carcinoma cell-specific mutation suggests that the inactivation of MALT1 expression but not the mutation promotes oral carcinoma progression PMID: 22752732
32. This is q review of the understanding of MALT1 function and regulation, and the development of small molecule MALT1 inhibitors for therapeutic applications. PMID: 25285878
33. MALT1 auto-proteolysis is essential for NF-kappaB-dependent gene transcription in activated lymphocytes. PMID: 25105596
34. Overexpression of CARMA-BCL10-MALT in T-ALL may contribute to the constitutive cleavage and inactivation of A20, which enhances NF-kappaB signaling and may be related to T-ALL pathogenesis. PMID: 25384343
35. MALT1 exerts its effect upon immune response through the initiation of cellular miR-2909 RNomics. PMID: 25500259
36. The MALT1 and MALT1-V1 variant expression level was downregulated in rheumatoid arthritis patients. PMID: 24971370
37. In the crystal structure of human MALT1casp-Ig3 in complex with the tricyclic phenothiazine derivative thioridazine the inhibitor is bound in a hydrophobic pocket far from the active site. PMID: 23946259
38. This review highlights the recent advances in the normal and disease-related functions of MALT1 PMID: 24004675
39. Combined immunodeficiency associated with homozygous MALT1 mutations. PMID: 24332264
40. our study implicates RIP1 ubiquitination as a critical component of API2-MALT1-dependent lymphomagenesis PMID: 23770847
41. Taken together, loss of MALT1 expression alters keratin expression and enhances proliferation of carcinoma cells, and may progress oral carcinomas into the advanced state. PMID: 23799590
42. Glutamate 549 at the dimerization interface is required for the formation of the enzymatically active, monoubiquitinated form of MALT1. PMID: 23977204
43. Structure-guided mutagenesis confirmed the observed interfaces in Bcl10 filament assembly and MALT1 activation in vitro and NF-kappaB activation in cells. PMID: 24074955
44. Overexpression of MALT1 partially rescues HECTD3 depletion-induced apoptosis. PMID: 23358872
45. USP2a plays an important role in TCR signaling by deSUMOylating TRAF6 and mediating TRAF6-MALT1 interaction PMID: 23264041
46. observations demonstrate MALT1 represses genes activating the aggressive phenotype of carcinoma cells, and MALT1 acts as a tumour suppressor and the loss of expression stimulates oral carcinoma progression PMID: 23778523
47. Report t(14;18)(q32;q21) involving IGH-MALT1 in extranodal diffuse large B-cell lymphomas of the breast and testis. PMID: 23018871
48. monoubiquitination of MALT1 is essential for its catalytic activation and is therefore a potential target for the treatment of ABC-DLBCL and for immunomodulation. PMID: 23416615
49. A selected lead compound, MI-2, featured direct binding to MALT1 and suppression of its protease function. PMID: 23238016
50. These phenothiazines selectively inhibit cleavage activity of recombinant and cellular MALT1 by a noncompetitive mechanism. PMID: 23238017
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相關疾病：

Immunodeficiency 12 (IMD12)
亞細胞定位：

Cytoplasm, perinuclear region. Nucleus.
蛋白家族：

Peptidase C14B family
組織特異性：

Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.
數據庫鏈接：

HGNC: 6819

OMIM: 604860

KEGG: hsa:10892

STRING: 9606.ENSP00000319279

UniGene: Hs.601217

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