MAFB Antibody, HRP conjugated
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中文名稱：MAFB兔多克隆抗體, HRP偶聯
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貨號：CSB-PA897570LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) MAFB Polyclonal antibody
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Uniprot No.：
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基因名：MAFB
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別名：Kreisler antibody; Kreisler (mouse) maf related leucine zipper homolog antibody; Kreisler maf related leucine zipper homolog antibody; KRML antibody; MAF bZIP transcription factor B antibody; Maf-B antibody; Mafb antibody; MAFB/Kreisler basic region/leucine zipper transcription factor antibody; MAFB_HUMAN antibody; MGC43127 antibody; Segmentation protein KR antibody; Transcription factor MafB antibody; V maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) antibody; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Transcription factor MafB protein (168-323AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain.
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基因功能參考文獻：
- This study further confirmed that the targeted single nucleotide polymorphisms at MAFB were associated with Non-syndromic cleft lip with or without cleft palate case-parent trios from Western Han Chinese population PMID: 30024657
- These results suggest that MAFB and MAFF play critical roles in the antitumor effects of retinoids by regulating the expression of retinoid target genes such as TFPI2 and can be promising for developing therapies to combat HCC invasion. PMID: 29757260
- MAFB enhanced leukemogenesis by the naturally occurring Notch1 mutants, decreased disease latency, and increased disease penetrance. PMID: 29138297
- USP5 regulates c-Maf stability and multiple myeloma cell survival. PMID: 28933784
- Data suggest that SUMOylated MAFB promotes colorectal cancer tumorigenesis through cell cycle regulation. PMID: 27829226
- these results demonstrate that MAFB critically determines the acquisition of the anti-inflammatory transcriptional and functional profiles of human macrophages PMID: 28093525
- The present study demonstrated that miR-152 was downregulated in NPC tissues and cell lines. In addition, miR-152 expression and MAFB knockdown inhibited cell proliferation, migration and invasion, and miR-152 suppressed the expression of MAFB at the mRNA and protein levels. PMID: 28000885
- Epidermal differentiation gene regulatory networks are controlled by MAF and MAFB. PMID: 27097296
- Loss of MAFB Function Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects. PMID: 27181683
- Results indicate a hepatocellular carcinoma (HCC) regulatory pathway involving MafB transcription factor and cyclin D1, the dysfunction of which drives proliferative character in HCC. PMID: 27448450
- DNMT3A R882 mutation is associated with elevated expression of MAFB and M4/M5 immunophenotype of acute myeloid leukemia blasts. PMID: 25721756
- MAFB is a regulator and a marker of adipose tissue inflammation, a process that subsequently causes insulin resistance PMID: 26115698
- MAFB represents a unique signature and likely important regulator of the primate islet beta-cell. PMID: 26554594
- The rs2902940A allele carriers in the MAFB conferred a decreased serum ApoAI level in controls and an increased risk of coronary artery disease and ischemic stroke. PMID: 26204962
- Gata3 interacted with Gcm2 and MafB, two known transcriptional regulators of parathyroid development, and synergistically stimulated the PTH promoter. PMID: 25917456
- MiR-223 negatively regulates the growth and migration of NPC cells via reducing MAFB expression, and this finding provides a novel insight into understanding miR-223 regulation mechanism in nasopharyngeal carcinoma tumorigenesis. PMID: 26055874
- rs6065259 was the most important single nucleotide polymorphism in MAFB (OR6065259-AA=0.45; 95% CI: 0.28 to 0.71; p=0.0027), followed by rs13041247; no association was found between rs11696257 and NSCLP. PMID: 24972815
- These findings indicate that only a few transactivation domain-specific mutations within MAFB cause multicentric carpotarsal osteolysis. PMID: 24989131
- Mafb is responsible for executing one branch of the SGN differentiation program orchestrated by the Gata3 transcriptional network PMID: 24327562
- MAFA, MAFB, NKX6.1, and PDX1 activity provides a gauge of islet beta cell function, with loss of MAFA (and/or MAFB) representing an early indicator of beta cell inactivity PMID: 23863625
- We identified MAFB mutations in all, including three novel missense mutations clustering within the hot spot mutation region PMID: 23956186
- data support the existence of a signaling cascade by which stimulation of macrophages with the IL-10 cytokine determines a sequential activation of STAT3 and MafB transcription factors PMID: 24472656
- miR-148a directly targeted MAFB mRNA by binding to the 3' untranslated region (3'UTR) and repressed MAFB protein expression PMID: 23225151
- the haematopoietic progenitor population can be the target for transformation in MafB-associated plasma cell neoplasias PMID: 22903061
- MAFB gene suggest a role for the development of orofacial clefting in hispanic population. PMID: 22753311
- Identified previously unreported missense mutations clustering within a 51 base pair region of the single exon of MAFB, validated by Sanger sequencing. PMID: 22387013
- The homozygous kreisler mutation eliminates most of rhombomere 5 and mis-specifies rhombomere 6, abolishes an early decrease in respiratory frequency within 10 min of hypoxia and an intrinsic hypoxic activation. PMID: 21839147
- findings confirmed the contribution of MAFB in the etiology of nonsyndromic orofacial clefts PMID: 21834038
- Abnormal expression of maf-b correlates with abnormal proliferation of acute myeloid leukemia cells. PMID: 21129249
- An association of ABCA4 and MAFB with non-syndromic cleft lip with or without cleft palate. PMID: 21567910
- MafB expression was higher in smokers with airflow limitation than in smokers without airflow limitation. PMID: 20969674
- These results suggest a suppressive effect of HBZ on Maf function, which may have a significant role in HTLV-1 related pathogenesis. PMID: 20506502
- MafB acts as a metastable switch to control expression of IFN-beta. PMID: 20581830
- Expression studies support a role for MAFB in palatal development. PMID: 20436469
- strong proliferative signals mediated by T-cell activation and interleukins (IL-4 and IL-12) downregulate the mafB messenger RNA transcript level when resting naive CD4+ T-helper cells enter the differentiation pathway in vitro. PMID: 12542795
- Our data show that human monocytes, but not neutrophils, macrophages, dendritic or natural killer cells, downregulate the expression of Mac-1 after overnight exposure to surface-bound IgG. PMID: 12542796
- novel role for MafB as a regulator of ERK-induced gene expression PMID: 15121870
- Low-density lipoprotein receptor-related protein intracellular domain co-localizes with MafB to the nucleus and negatively regulates its transcriptional activity PMID: 15135046
- high PU.1 activity favors dendritic cells at the expense of macrophage fate by inhibiting expression and activity of the macrophage factor MafB. PMID: 15598817
- MafB is a key regulator of monocytopoiesis PMID: 16456583
- Microarray analysis of Dupuytren's disease tissue has identified significant upregulated gene expression of MafB PMID: 16473681
- MafB may be a prognostic marker in the risk stratification of MM patients. PMID: 18830254
- the vitamin D(3)/Hox-A10 pathway supports MafB function during the induction of monocyte differentiation. PMID: 18832725
- Identification of primary MAFB target genes in multiple myeloma PMID: 19013005
- identified a Tfe3-binding site (EBox) in the MAFB promoter region PMID: 19332055
- Both OH-2 and primary cells have a complex secondary translocation in which the IGK 3' enhancer is inserted between MYC and MAFB, resulting in dysregulation of both oncogenes PMID: 19395026
- Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18615156
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相關疾病：Multicentric carpotarsal osteolysis syndrome (MCTO); Duane retraction syndrome 3 with or without deafness (DURS3)
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亞細胞定位：Nucleus.
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蛋白家族：BZIP family, Maf subfamily
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組織特異性：Ubiquitous.
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