MAFB Antibody, Biotin conjugated

說明書

中文名稱：

MAFB兔多克隆抗體, Biotin偶聯(lián)
貨號：

CSB-PA897570LD01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) MAFB Polyclonal antibody
Uniprot No.：

Q9Y5Q3
基因名：

MAFB
別名：

Kreisler antibody; Kreisler (mouse) maf related leucine zipper homolog antibody; Kreisler maf related leucine zipper homolog antibody; KRML antibody; MAF bZIP transcription factor B antibody; Maf-B antibody; Mafb antibody; MAFB/Kreisler basic region/leucine zipper transcription factor antibody; MAFB_HUMAN antibody; MGC43127 antibody; Segmentation protein KR antibody; Transcription factor MafB antibody; V maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) antibody; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Transcription factor MafB protein (168-323AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain.
基因功能參考文獻：
1. This study further confirmed that the targeted single nucleotide polymorphisms at MAFB were associated with Non-syndromic cleft lip with or without cleft palate case-parent trios from Western Han Chinese population PMID: 30024657
2. These results suggest that MAFB and MAFF play critical roles in the antitumor effects of retinoids by regulating the expression of retinoid target genes such as TFPI2 and can be promising for developing therapies to combat HCC invasion. PMID: 29757260
3. MAFB enhanced leukemogenesis by the naturally occurring Notch1 mutants, decreased disease latency, and increased disease penetrance. PMID: 29138297
4. USP5 regulates c-Maf stability and multiple myeloma cell survival. PMID: 28933784
5. Data suggest that SUMOylated MAFB promotes colorectal cancer tumorigenesis through cell cycle regulation. PMID: 27829226
6. these results demonstrate that MAFB critically determines the acquisition of the anti-inflammatory transcriptional and functional profiles of human macrophages PMID: 28093525
7. The present study demonstrated that miR-152 was downregulated in NPC tissues and cell lines. In addition, miR-152 expression and MAFB knockdown inhibited cell proliferation, migration and invasion, and miR-152 suppressed the expression of MAFB at the mRNA and protein levels. PMID: 28000885
8. Epidermal differentiation gene regulatory networks are controlled by MAF and MAFB. PMID: 27097296
9. Loss of MAFB Function Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects. PMID: 27181683
10. Results indicate a hepatocellular carcinoma (HCC) regulatory pathway involving MafB transcription factor and cyclin D1, the dysfunction of which drives proliferative character in HCC. PMID: 27448450
11. DNMT3A R882 mutation is associated with elevated expression of MAFB and M4/M5 immunophenotype of acute myeloid leukemia blasts. PMID: 25721756
12. MAFB is a regulator and a marker of adipose tissue inflammation, a process that subsequently causes insulin resistance PMID: 26115698
13. MAFB represents a unique signature and likely important regulator of the primate islet beta-cell. PMID: 26554594
14. The rs2902940A allele carriers in the MAFB conferred a decreased serum ApoAI level in controls and an increased risk of coronary artery disease and ischemic stroke. PMID: 26204962
15. Gata3 interacted with Gcm2 and MafB, two known transcriptional regulators of parathyroid development, and synergistically stimulated the PTH promoter. PMID: 25917456
16. MiR-223 negatively regulates the growth and migration of NPC cells via reducing MAFB expression, and this finding provides a novel insight into understanding miR-223 regulation mechanism in nasopharyngeal carcinoma tumorigenesis. PMID: 26055874
17. rs6065259 was the most important single nucleotide polymorphism in MAFB (OR6065259-AA=0.45; 95% CI: 0.28 to 0.71; p=0.0027), followed by rs13041247; no association was found between rs11696257 and NSCLP. PMID: 24972815
18. These findings indicate that only a few transactivation domain-specific mutations within MAFB cause multicentric carpotarsal osteolysis. PMID: 24989131
19. Mafb is responsible for executing one branch of the SGN differentiation program orchestrated by the Gata3 transcriptional network PMID: 24327562
20. MAFA, MAFB, NKX6.1, and PDX1 activity provides a gauge of islet beta cell function, with loss of MAFA (and/or MAFB) representing an early indicator of beta cell inactivity PMID: 23863625
21. We identified MAFB mutations in all, including three novel missense mutations clustering within the hot spot mutation region PMID: 23956186
22. data support the existence of a signaling cascade by which stimulation of macrophages with the IL-10 cytokine determines a sequential activation of STAT3 and MafB transcription factors PMID: 24472656
23. miR-148a directly targeted MAFB mRNA by binding to the 3' untranslated region (3'UTR) and repressed MAFB protein expression PMID: 23225151
24. the haematopoietic progenitor population can be the target for transformation in MafB-associated plasma cell neoplasias PMID: 22903061
25. MAFB gene suggest a role for the development of orofacial clefting in hispanic population. PMID: 22753311
26. Identified previously unreported missense mutations clustering within a 51 base pair region of the single exon of MAFB, validated by Sanger sequencing. PMID: 22387013
27. The homozygous kreisler mutation eliminates most of rhombomere 5 and mis-specifies rhombomere 6, abolishes an early decrease in respiratory frequency within 10 min of hypoxia and an intrinsic hypoxic activation. PMID: 21839147
28. findings confirmed the contribution of MAFB in the etiology of nonsyndromic orofacial clefts PMID: 21834038
29. Abnormal expression of maf-b correlates with abnormal proliferation of acute myeloid leukemia cells. PMID: 21129249
30. An association of ABCA4 and MAFB with non-syndromic cleft lip with or without cleft palate. PMID: 21567910
31. MafB expression was higher in smokers with airflow limitation than in smokers without airflow limitation. PMID: 20969674
32. These results suggest a suppressive effect of HBZ on Maf function, which may have a significant role in HTLV-1 related pathogenesis. PMID: 20506502
33. MafB acts as a metastable switch to control expression of IFN-beta. PMID: 20581830
34. Expression studies support a role for MAFB in palatal development. PMID: 20436469
35. strong proliferative signals mediated by T-cell activation and interleukins (IL-4 and IL-12) downregulate the mafB messenger RNA transcript level when resting naive CD4+ T-helper cells enter the differentiation pathway in vitro. PMID: 12542795
36. Our data show that human monocytes, but not neutrophils, macrophages, dendritic or natural killer cells, downregulate the expression of Mac-1 after overnight exposure to surface-bound IgG. PMID: 12542796
37. novel role for MafB as a regulator of ERK-induced gene expression PMID: 15121870
38. Low-density lipoprotein receptor-related protein intracellular domain co-localizes with MafB to the nucleus and negatively regulates its transcriptional activity PMID: 15135046
39. high PU.1 activity favors dendritic cells at the expense of macrophage fate by inhibiting expression and activity of the macrophage factor MafB. PMID: 15598817
40. MafB is a key regulator of monocytopoiesis PMID: 16456583
41. Microarray analysis of Dupuytren's disease tissue has identified significant upregulated gene expression of MafB PMID: 16473681
42. MafB may be a prognostic marker in the risk stratification of MM patients. PMID: 18830254
43. the vitamin D(3)/Hox-A10 pathway supports MafB function during the induction of monocyte differentiation. PMID: 18832725
44. Identification of primary MAFB target genes in multiple myeloma PMID: 19013005
45. identified a Tfe3-binding site (EBox) in the MAFB promoter region PMID: 19332055
46. Both OH-2 and primary cells have a complex secondary translocation in which the IGK 3' enhancer is inserted between MYC and MAFB, resulting in dysregulation of both oncogenes PMID: 19395026
47. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18615156
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相關疾病：

Multicentric carpotarsal osteolysis syndrome (MCTO); Duane retraction syndrome 3 with or without deafness (DURS3)
亞細胞定位：

Nucleus.
蛋白家族：

BZIP family, Maf subfamily
組織特異性：

Ubiquitous.
數(shù)據(jù)庫鏈接：

HGNC: 6408

OMIM: 166300

KEGG: hsa:9935

STRING: 9606.ENSP00000362410

UniGene: Hs.169487

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