KLK11 Antibody, FITC conjugated
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中文名稱：KLK11兔多克隆抗體, FITC偶聯
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貨號：CSB-PA880069LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) KLK11 Polyclonal antibody
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Uniprot No.：
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基因名：KLK11
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別名：Kallikrein-11 (hK11) (EC 3.4.21.-) (Hippostasin) (Serine protease 20) (Trypsin-like protease) [Cleaved into: Kallikrein-11 inactive chain 1, Kallikrein-11 inactive chain 2], KLK11, PRSS20 TLSP
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Kallikrein-11 protein (90-282aa)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
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基因功能參考文獻：
- Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases PMID: 29095848
- Variations in KLK15, but not KLK11 expression were significantly associated with prognosis in gastric cancer PMID: 26224476
- KLK11 mRNA expression could be considered as a new molecular prognostic biomarker in colorectal adenocarcinoma PMID: 25123036
- hK11 expression in gastric cancer appears to be associated with a better prognosis. hK11 may be a prognostic biomarker of gastric cancer. PMID: 24169449
- The aim of this study was to monitor serum levels of two microRNAs (miR-21 and miR-141) and three kallikreins (hK3/PSA, hK11, and hK13) before and 1, 5, and 30 days after radical prostatectomy. PMID: 24288670
- Our data showed that UVB-induced TSLP might increase secretion of the T-helper type 2-attracting chemokine (c-c motif) ligand 17 by human dendritic cells. PMID: 23639975
- HOXB8 and KLK11 may be classified as valuable biomarkers, as they can predict the effects of FOLFOX4 chemotherapy in primary advanced colorectal cancer patients PMID: 23647300
- Human airway trypsin-like protease can stimulate mucin5AC hypersecretion through a PAR2-mediated signaling pathway in 16HBE cells. PMID: 23602830
- Patients harboring KLK11-positive tumors had a significantly decreased risk of death. PMID: 22429520
- Low KLK11 protein expression is associated with gastric cancer. PMID: 21618246
- For the first time, we report lower expression of KLK11 in CaP compared to BPH and slight upregulation of KLK11 in advanced tumors compared to localized ones PMID: 21520985
- the up-regulation of TMPRSS2 and the down-regulation of KLK11 in advanced and more aggressive tumors may open the feasibility of being used as biomarkers distinguishing the tumor aggressiveness as well as novel prognostic indicators for prostate cancer. PMID: 19242826
- hK11 may be another prognostic biomarker of low rectal carcinoma. Strong positive hK11 staining associated with various clinicopathologic features. Patients with weak hK11 positive expression showed better survival rates. PMID: 19184568
- Data show that it was unable to distinguish men with and without prostate cancer using multiple kallikreins as urinary biomarkers. PMID: 19560453
- may be useful marker for distinguishing prostate cancer and benign prostatic hypertrophy PMID: 11550212
- Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma. PMID: 11782391
- Hippostasin isoform 3 may play a role in the prostate, including reproductive and/or tumorigenic functions. PMID: 12539228
- There is a significant association between lower expression of prostate-type KLK11 and higher tumor stage, Gleason score, and tumor grade. PMID: 12736044
- hK11 is a novel, independent marker of favorable prognosis in patients with ovarian cancer PMID: 12845660
- KLK11 expression may play an important role in ovarian cancer development PMID: 15102682
- Kallikrein 11 is an independent marker of favorable prognosis in ovarian cancer patients. PMID: 15329323
- KLK11 was found to be highly expressed in 43/66 (65%) of prostate cancer samples PMID: 15893744
- results suggest a co-regulation of KLK10 and KLK11 expression in lung and a lack of KLK10 suppressor role in non-small-cell lung cancer PMID: 16800740
- The gene promoter regions of kallikrein and the corresponding transcriptional initiation sites were studied. PMID: 16911518
- The hormone-specific upregulation of PSA, KLK10 and KLK11 in the breast cancer cell line T47D is dependent on major intracellular signaling pathways. PMID: 18515984
- Treatment of PC3 prostate cancer cells with mitoxantrone, etoposide, doxorubicin and carboplatin induces distinct alterations in the expression of kallikreins 5 and 11. PMID: 19190824
- synergistic effects between estrogens and androgens on estrogen-sensitive genes may have implications on the role of the kallikreins 10, 11, and 14 in associated risk of breast cancer and progression. PMID: 19383315
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亞細胞定位：[Isoform 1]: Secreted.; [Isoform 2]: Golgi apparatus.
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蛋白家族：Peptidase S1 family, Kallikrein subfamily
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組織特異性：Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).
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