HNMT Antibody
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中文名稱：HNMT兔多克隆抗體
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貨號：CSB-PA010598GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：HNMT
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別名：EC 2.1.1.8 antibody; Histamine N methyltransferase antibody; Histamine N-methyltransferase antibody; HMT antibody; HNMT antibody; HNMT S1 antibody; HNMT S2 antibody; HNMT_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human HNMT
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
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基因功能參考文獻：
- Histamine N-methyltransferase plays a central role in the degradation of the neurotransmitter histamine. Leucine 208 is a critical amino acid residue to maintain the structural integrity of the protein. Replacements by other amino acid residues have profound effects on stability and catalytic activity. PMID: 27769936
- NHMT polymorphisms are not associated with Parkinson's disease, ALS and multiple system atrophy in Chinese population. PMID: 29564728
- miR-223 participates in the pathogenesis of atopic dermatitis through upregulating HNMT indirectly to degrade the excessive histamine. PMID: 29506638
- The C allele for the HNMT polymorphism was associated with a lower degree of disability due to migraine (OR, 10.0; 95% CI, 2.65-37.6). In contrast, presence of the T allele (in heterozygous individuals) was associated with higher degree of disability (OR, 37.1; 95% CI, 4.37-315.2) PMID: 27130307
- This study shown that eight linked SNPs (r(2) = 1) in the HNMT gene were associated with sedation according to the generalized linear model, adjusted for age, gender and BMI (false-discovery-rate-adjusted p = 0.013). PMID: 28400155
- Genotype and allelic variant frequencies of HNMT rs11558538 SNP 205 restless legs syndrome (RLS) patients and 410 controls using a TaqMan assay: HNMT rs11558538 genotypes allelic variants frequencies were similar between RLS patients and controls and not influenced by gender, family history of RLS, or RLS severity. Some evidence that RLS patients carrying the genotype rs11558538TT had an earlier age at onset. PMID: 27837280
- The present meta-analysis confirms published evidence suggesting that the HNMT rs11558538 minor allele is related to a reduced risk of developing Parkinson disease PMID: 27399132
- this study shows that single nucleotide polymorphism is associated with the severity of allergic rhinitis in a group of Mexican children PMID: 27255477
- The T allele of rs3787429 exhibited protective effect against CHF under the dominant and additive models , while, for SNPs in HRH2, DAO, and HNMT, no significant associations were observed in the present study PMID: 26989676
- HNMT is identified as a novel gene responsible for intellectual disability. The consequences of the identified missense mutations on the protein function are discussed. PMID: 26206890
- HRH1-17 TT and HNMT-1639 TT genotypes were associated with the allergic asthma phenotype among African-American children and that the ABP 4107 GG genotype was associated with nonallergic asthma among white children. PMID: 25909280
- results suggest that the heterozygous Thr/Ile genotype at the HNMT-Thr105Ile locus and the minor Ile105 allele protect against Parkinson's disease and schizophrenia in Han Chinese. PMID: 25768024
- The polymorphisms of HNMT and HRH3 were irrelevant with breast cancer in the present study. PMID: 24835231
- The A939G HNMT polymorphism is associated with autoimmune MG, while no association with C314T SNP was found. PMID: 23932992
- The results of this study indicated that Histamine N-methyltransferase Thr105Ile polymorphism is associated Parkinson's disease. PMID: 21794955
- Lack of the association of HNMT Thr105Ile functional polymorphism with Alzheimer's disease is found. PMID: 21138759
- our results suggest that, despite the possible role of histamine in the inflammatory processes related with the pathogenesis of MS, HNMT polymorphism is not related with the risk for MS in Caucasian Spanish people PMID: 19538200
- This study do not support the HNMT Thr105Ile variant as a factor in disease development or a genetic link between the disorders. PMID: 19773194
- identification of several novel HNMT polymorphisms, identification of the HNMT core promoter PMID: 12167489
- for the histamine N-methyltransferase gene no differences in allele distribution were found in patients with food allergy and sprue compared to controls except for the 314t allele PMID: 12755416
- Single nucleotide polymorphisms were identified in HNMT in Chinese and their relationship assessed with its activity. PMID: 12835614
- the C314T polymorphism was functionally important and contributes in part to phenotypic variance of histamine N-methyltransferase activity in Chinese Han population PMID: 12867290
- Studies showed a new brain HNMT mRNA species, named HNMT-Short (HNMT-S), which encodes a 126-amino-acid protein. PMID: 14667820
- no evidence for the involvement of HNMT polymorphisms in the susceptibility to gastric ulcer PMID: 15551002
- Polymorphisms and haplotypes in the the HNMT gene are not associated with asthma in the Indian population. PMID: 16205835
- An association of the HNMT Thr105Ile polymorphism, but not of the ABP1 His645Asp polymorphism, with PD was observed. Patients with PD showed a higher frequency of homozygous HNMT genotypes PMID: 17985251
- No association can be found in the involvement of HNMT C314T polymorphism in the susceptibility to duodenal ulcer PMID: 18086566
- Molecular dynamics simulations indicate that the histamine N-methyltransferase T105I polymorphism affects both active site structure and dynamics. PMID: 18154359
- histamine N-methyltransferase is not related with the risk for migraine. PMID: 18266724
- These results, combined with previous findings indicating alterations in the frequency for the HNMT Thr105Ile polymorphism in patients with PD, suggest that alterations of histamine homeostasis in the SNC are associated with risk of movement disorders. PMID: 18543121
- Increased histamine levels in patients with atopic dermatitis may result, at least in part, from reduced enzymatic inactivation via HNMT. PMID: 19025430
- The HNMT 939A>G polymorphism lowers HNMT enzymatic activity by decreasing HNMT mRNA stability, which leads to an increase in the histamine level and contributes to the development of aspirin intolerant chronic urticaria. PMID: 19178400
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相關疾病：Mental retardation, autosomal recessive 51 (MRT51)
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亞細胞定位：Cytoplasm.
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蛋白家族：Class I-like SAM-binding methyltransferase superfamily, HNMT family
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