HAPLN1 Antibody
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中文名稱：HAPLN1兔多克隆抗體
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貨號：CSB-PA010130ESR2HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human bladder cancer using CSB-PA010130ESR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA010130ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) HAPLN1 Polyclonal antibody
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Uniprot No.：
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基因名：HAPLN1
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別名：Cartilage link protein antibody; cartilage linking protein 1 antibody; Cartilage-link protein antibody; Cartilage-linking protein 1 antibody; CLP antibody; CRTL1 antibody; Crtl1l antibody; HAPLN1 antibody; HPLN1_HUMAN antibody; Hyaluronan and proteoglycan link protein 1 antibody; Hyaluronan and proteoglycan link protein 1 precursor antibody; LP antibody; Proteoglycan link protein antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Hyaluronan and proteoglycan link protein 1 protein (165-354AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
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基因功能參考文獻：
- HAPLN1 reflects a signaling network leading to stemness, mesenchymal commitment and hepatocellular carcinoma progression PMID: 27191501
- CSGalNAcT-1 and Hapln-1 may play important roles in the pathogenesis of Kashin-Beck disease and osteoarthritis. PMID: 23748413
- HAPLN1 is overexpressed in metastatic melanoma and is secreted exclusively by the tumor cells PMID: 22159717
- Single-nucleotide polymorphism in the hyaluronan and proteoglycan link protein 1 (HAPLN1) gene is associated with spinal osteophyte formation and disc degeneration in Japanese women. PMID: 20953637
- An in vitro model of perineuronal nets has been developed demonstrating that cartilage link protein (along with hyaluronan synthase) are necessary for their formation. PMID: 20584105
- link protein may function as a stabilizer of the interaction between aggrecan and hyaluronan in cartilage and between versican and hyaluronan in many tissues PMID: 14724283
- SOX9 is a key regulator of CRTL1 PMID: 15456769
- cLP and versican did not bind directly to each other in solution yet formed ternary complexes with hyaluronan PMID: 15590670
- Overexpression of HAPLN1 and its SP-IgV domain increases tumorigenic properties of mesothelioma. Thus, targeting the SP-IgV domain may be one of the therapeutic approaches in cancer treatment. PMID: 19351750
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亞細胞定位：Secreted, extracellular space, extracellular matrix.
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蛋白家族：HAPLN family
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組織特異性：Widely expressed. Weakly expressed in the brain.
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數據庫鏈接：
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