GRM5 Antibody

說明書

中文名稱：

GRM5兔多克隆抗體
貨號：

CSB-PA003236
規格：

￥1090
圖片：
Western Blot analysis of HT29 cells using mGluR5 Polyclonal Antibody

Western blot analysis of mouse-kidney mouse-brain lysis using mGluR5 antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P41594
基因名：

GRM5
別名：

Glutamate receptor metabotropic 5 antibody; GPRC1E antibody; Grm5 antibody; GRM5_HUMAN antibody; Metabotropic glutamate receptor 5 antibody; Metabotropic glutamate receptor 5 variant F antibody; Metabotropic glutamate receptor 5 variant G antibody; Metabotropic glutamate receptor 5 variant H antibody; mGlu5 antibody; mGluR5 antibody; PPP1R86 antibody; Protein phosphatase 1 regulatory subunit 86 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the N-terminal region of Human mGluR5.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
基因功能參考文獻：
1. clinical evidence for altered mGluR5 signaling in the amygdala in alcohol use disorder PMID: 29317611
2. We anticipate that the resulted outcome could be supportive to discover potent negative allosteric modulators for metabotropic glutamate receptor 5 (mGluR5). PMID: 29806525
3. This study provides information concerning the changes in the expression of GABAergic and glutamatergic markers in mice lacking the mGlu5. PMID: 27581816
4. We report that expression of a key regulator of synaptic protein synthesis, the metabotropic glutamate receptor 5 (mGlu5) protein, is significantly reduced in both the brains of RS model mice and in the motor cortex of human RS autopsy samples. PMID: 26936821
5. once at the inner nuclear membrane, mGluR5 is stably retained via interactions with chromatin and is perfectly positioned to regulate nucleoplasmic Ca(2+)in situ PMID: 28096465
6. Overall, these data posit mGluR5 in key paralimbic areas as a strong determinant of the temperament trait novelty seeking. These data add to our understanding of how brain neurochemistry accounts for the variation in human behavior and strongly support further research on mGluR5 as a potential therapeutic target in neuropsychiatric disorders associated with abnormal novelty-seeking behaviors. PMID: 27283933
7. Decrease of mGluR5 receptor density goes parallel with changes in enkephalin and substance P immunoreactivity in Huntington's disease PMID: 24969128
8. The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in the pathophysiology of mood and anxiety disorders. PMID: 26645628
9. The interaction between GRM5 and cellular prion protein has a central role in transgenic mouse model of Alzheimer's disease pathogenesis. PMID: 26667279
10. Data suggest that metabotropic glutamate receptors recycling is completely dependent on the activity of PP2A whereas, PP2B has partial effect on this process. PMID: 26311002
11. findings provide evidence for decreased expression of metabotropic glutamate receptor 5 and its signaling components representing a key pathophysiological hallmark in autism spectrum disorder. PMID: 26052099
12. Study provided evidence that protein expression of mGluR5 is significantly higher (total: 42%; monomer: 25%; dimer: 52%) in the hippocampal CA1 region of schizophrenia subjects relative to healthy controls PMID: 26048293
13. Results provide compelling evidence that mGluR5 regulation is altered in schizophrenia, likely contributing to the altered glutamatergic signaling that is associated with the disorder PMID: 25778620
14. This review supports altered mGluR5 functioning as a convergent point in ASD pathogenesis and indicates more research is warranted into mGluR5 as a potential therapeutic target. PMID: 25704074
15. both an increased and reduced mGlu5 functioning seem to be associated with Intellectual Disability and autism spectrum disorders. PMID: 24548786
16. significant positive correlation between Yale-Brown Obsessive Compulsive Scale obsession sub-score and mGluR5 distribution volume ratio in the cortico-striatal-thalamo-cortical brain circuit; results suggest obsessions in particular might have an underlying glutamatergic pathology related to mGluR5 PMID: 24833114
17. gnificantly higher expression level in the metabotropic receptor genes GRM5 in Locus coeruleus neurons. PMID: 24925192
18. Findings demonstrate a developmental regulation of mGluR5 in the hippocampus and suggest a role for this receptor in astrocytes during early development in Down's syndrome hippocampus PMID: 25115540
19. findings suggest that changes in astrocyte mGlu5 receptors may be part of an adaptive response to the progressive nature of Alzheimer's disease PMID: 19401173
20. tobacco smoking was associated with lower mGluR5 availability in the brain in both cocaine users and controls, while cocaine use was not linked to detectable mGluR5 alterations PMID: 23628984
21. Our findings highlight the subtleties of allosteric modulator binding to mGlu5 and demonstrate the utility in incorporating SAR information to strengthen the interpretation and analyses of docking and mutational data. PMID: 24528109
22. a dysregulation of its signaling in fragile X mental retardation gene 1 premutation carriers, which would likely contribute to the development and severity of fragile X-associated tremor/atasia syndrome. PMID: 24332449
23. reflected in the immunoblotting data Mglur5 receptors were detected at higher levels of expression in patient with cortical dysplasia with intractable epilepsy. PMID: 25003238
24. Review provides an update of the current state of the art of mGlu5 receptor-based manipulations to alleviate the symptoms of Parkinson's disease. PMID: 24040811
25. The pattern of mGluR5 expression by neural stem/progenitor cells, neuroblasts and neurons provides important anatomical evidence for the role of mGluR5 in the regulation of human hippocampal development PMID: 23225313
26. This study demonistrated that mGluR5 upregulation also participates in counterbalance mechanisms along the hyperexcitable circuitry uniquely altered in TLE hippocampal formation. PMID: 23804486
27. This study demonistrated that metabotropic receptor mGluR5 was found to be expressed by just 40% of striatal neurons in young individuals, with significant intensity variations among the neurons. PMID: 23627706
28. this study provides evidence that GRK2 mediates phosphorylation-independent mGluR5 desensitization via the interaction between the RGS domain and Galphaq in HEK 293 cells. PMID: 23705503
29. Knockdown of mGluR5 inhibited icariin induced reactive oxygen species generation and NF-kappaB nuclear translocation. PMID: 23524143
30. mGluR5 inhibition and stimulation in the nucleus accumbens can regulate cocaine-seeking, and demonstrate that one mechanism for this effect is via interactions with Homer proteins PMID: 22340009
31. Plasma glutamate-modulated interaction of A2AR and mGluR5 on BMDCs aggravates traumatic brain injury-induced acute lung injury. PMID: 23478188
32. mGluR5 is expressed by a variety of cells such as neural stem cells in the frontal cortex, ventricular zone and subventricular zone in human fetuses. PMID: 22543119
33. data demonstrate that mGluR5 receptors internalize without the application of ligand and the internalized receptors recycle back to the cell surface following constitutive endocytosis. PMID: 22995293
34. Calmodulin-regulated Siah-1A binding to mGluR5 dynamically regulates mGluR5 trafficking PMID: 23152621
35. Human mGluR5, GABA(A,B), and CB(1,2) receptors are abundantly expressed along the vago-vagal neural pathway and involved in the triggering of transient lower esophageal sphincter relaxations PMID: 22256945
36. the results of this study show that using the equilibrium method is an acceptable alternative to the standard kinetic method when using 18F-SP203 to measure mGluR5 PMID: 22032949
37. Elevated glutamatergic transmission as measured with increased mGluR5 specific binding is associated with human motor complications; its antagonism can be targeted for patients' treatment. PMID: 20036444
38. Metabotropic glutamate receptor 5 upregulation in children with autism is associated with underexpression of both Fragile X mental retardation protein and GABAA receptor beta 3 in adults with autism. PMID: 21901840
39. mGluR5 promoted the proliferation of human embryonic cortical neural stem/progenitor cells PMID: 21723923
40. Results highlight the therapeutic importance of mGluR5 antagonists in alpha-synucleinopathies. PMID: 21103359
41. mGLUR5 and 1,4,5-InsP3 signaling control calcium release PMID: 12119301
42. Data report the isolation of a novel gene termed metabotropic glutamate receptor 5-related (mGluR5R) [mGluR5R]. PMID: 12531512
43. Data report the identification of a novel variant of the G-protein coupled metabotropic glutamate receptor mGlu5 (hmGlu5d) generated by alternative splicing at the C-terminal domain. PMID: 12531526
44. mGlu5 on nuclear membranes has a role in mediating intranuclear Ca2+ changes in heterologous cell types and neurons PMID: 12736269
45. alternative 5'-splicing and usage of multiple promoters may contribute to regulatory mechanisms for tissue- and context-specific expression of the mGluR5 gene PMID: 12783878
46. activation of mGluR5 causes translocation of both gammaPKC and deltaPKC to the plasma membrane. deltaPKC, but not gammaPKC, phosphorylates mGluR5 Thr(840), leading to the blockade of both Ca2+ oscillations and gammaPKC cycling. PMID: 14561742
47. We found a selective expression of the group I receptor mGluR5 in human parasympathetic Onuf's nucleus, strengthening the hypothesis that mGluR expression may provide a possible clue to the selective vulnerability in ALS. PMID: 15076751
48. it is phosphorylation of Ser-839, not Thr-840, that is absolutely required for the unique Ca2+ oscillations produced by mGluR5 activation PMID: 15894802
49. there is an alpha-actinin-1-dependent mGlu(5b) receptor association with the actin cytoskeleton modulating receptor cell surface expression and functioning PMID: 17311919
50. We documented for the first time the expression of the mGluR5 and EAAT1 in MG-63 cells, as well as the ability of dexamethasone to upregulate the expression of the mGluR5 and EAAT1 in the MG-63 cells. PMID: 17627080
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 3 family
數據庫鏈接：

HGNC: 4597

OMIM: 604102

KEGG: hsa:2915

STRING: 9606.ENSP00000306138

UniGene: Hs.147361

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