GRIK2 Antibody, HRP conjugated
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中文名稱：GRIK2兔多克隆抗體, HRP偶聯
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貨號：CSB-PA618751LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) GRIK2 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：bA487F5.1 antibody; EAA4 antibody; Excitatory amino acid receptor 4 antibody; GLR 6 antibody; GLR6 antibody; GluK2 antibody; GLUK6 antibody; GLUR 6 antibody; GluR-6 antibody; GluR6 antibody; Glutamate receptor 6 antibody; Glutamate receptor antibody; glutamate receptor form A antibody; glutamate receptor form B antibody; glutamate receptor form C antibody; glutamate receptor form D antibody; glutamate receptor form E antibody; Glutamate receptor ionotropic kainate 2 antibody; GRIK 2 antibody; GRIK2 antibody; GRIK2 protein antibody; GRIK2_HUMAN antibody; ionotropic kainate 2 antibody; MRT6 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Glutamate receptor ionotropic, kainate 2 protein (203-500AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. Modulates cell surface expression of NETO2.; Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures. Functions in dorsal root ganglion neurons.
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基因功能參考文獻：
- results suggest that PKC SUMOylation is an important regulator of the 14-3-3 and GluK2a protein complex and may contribute to regulate the decay kinetics of kainate receptor-excitatory postsynaptic currents PMID: 28837400
- these findings indicate that GRIK2 has a role in the maintenance of urothelial cancer stem cells and that GRIK2 and ALDH1 can be prognosis prediction markers for urinary tract carcinomas PMID: 28418868
- TTBK2 down-regulates GluK2 activity by decreasing the receptor protein abundance in the cell membrane via RAB5-dependent endocytosis. PMID: 27607061
- In the Han population in Central China, the polymorphisms of SNP rs9390754 in the GRIK2 gene may be associated with epilepsy susceptibility. PMID: 27324535
- Study demonstrates that co-assembly of recombinant kainate receptors (GluK1 and GluK2) with the Neto1 and Neto2 auxiliary subunits alters their onset and recovery from desensitization in a subunit-dependent manner PMID: 26277340
- This study found in GRIK2 (glutamate receptor, ionotropic kainate 2) was most significant and also showed significant correlations with gene expression. PMID: 24662927
- This study showed that Gluk2 association with obsessive-compulsive disorder. PMID: 24821223
- Parkin interacts with the kainate receptor GluK2 subunit and regulates KAR function. PMID: 25316086
- High risk genetic markers of paranoid schizophrenia were GRIK2*ATG and GRIK2*TGG in Tatars. PMID: 25842862
- The present study reveals an additional mechanism for the regulation of GluK2-containing kainate receptors by Src family kinases, which may be of pathological significance in ischemic stroke. PMID: 25201974
- we found no association between rs1556995 in GRIK2 and clozapine-induced obsessive-compulsive (OC) symptoms, implying that that GRIK2 may not play a role in the development of OC symptoms in schizophrenia patients PMID: 23660601
- Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state. PMID: 23713029
- 14-3-3 proteins are an important regulator of GluK2a-containing KARs and may contribute to the slow decay kinetics of native KAR-EPSCs. PMID: 23861400
- Kainate receptor GluK2a post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis PMID: 23400781
- Eight chromosome 6 SNPs, having the most significant differences, were delineated: rs10499298, rs10499299, rs17827966, rs1224329, rs1150790, rs713050, rs2518344 and rs487083; all were associated with genes GRIK2. PMID: 23037145
- The ACAG haplotype in the 13th haplotype block of the GRIK2 gene was associated with somatic anxiety. PMID: 22429480
- Comprehensive analytical methods applied to a much larger sample than in previous studies do not support a role for GRIK2 as a genetic modifier of age at onset of clinical symptoms in Huntington's disease. PMID: 22771793
- Convergent functional genomics allowed the identification of novel candidate genes, GRIK2 and NPAS2, involved in glutamatergic neurotransmission and the circadian rhythm, respectively, that are potentially associated with CFS. PMID: 21912186
- Genotyping and linkage analysis excluded linkage of the GRIK2 gene and TUSC3 gene with mental retardation. PMID: 21557188
- This study supports previously reported findings of association between proximal GRIK2 single nucleotide polymorphism and obsessive-compulsive disorder in a comprehensive evaluation of the gene PMID: 20370803
- human GluK2 is a slowly activating channel but more sensitive to glutamate, as compared to the rat ortholog; the M867I mutation does not affect the rate the equilibrium constants of the channel opening but does slow down the channel desensitization rate PMID: 20863077
- Spliced variants of ionotropic glutamate receptor GluR6 is associated with astrocytoma. PMID: 20230879
- phosphorylation of PKC sites on GluR6 regulates surface expression of GluR6 at distinct intracellular trafficking pathways PMID: 19920140
- Linkage and association of the glutamate receptor 6 gene with autism PMID: 11920157
- Specific alleles in GluR6 and CA150 locus were only observed in HD patients. PMID: 12821179
- describes the time course of the open-channel form of the receptor as a function of glutamate concentration PMID: 14567698
- Using three single nucleotide polymorphisms in GRIK2 and one in GRIK3, we found no evidence for association with Obssessive-Compulsive disorder in case-control or family-based analyses. PMID: 15094479
- In this study, the maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia. PMID: 15305151
- The modifier effect is actually due to the TAA repeat itself, possibly via a functional consequence on the GRIK2 mRNA. PMID: 16959037
- Our data on altered functional properties of GluR6(M836I) provide a functional basis for the postulated linkage of GluR6 to autism. PMID: 17167233
- phosphorylation of the C-terminal tail of GluR6 by PKA leads to potentiation of whole cell response PMID: 17379418
- These results suggest a potential association between GRIK2 and autism in the Korean population. PMID: 17428563
- Mutations of GluR6 are unlikely to be associated with autism in the Indian population. PMID: 17712621
- report a complex mutation in the ionotropic glutamate receptor 6 gene (GRIK2, also called "GLUR6") that cosegregates with moderate-to-severe nonsyndromic autosomal recessive mental retardation in a large, consanguineous Iranian family PMID: 17847003
- Overall, our data indicate that hGluR6c might have unique properties in non-nervous cells and in the first stages of CNS development. PMID: 18289788
- the apo state of GluR6 undergoes a cleft closure of 29-30 degrees upon binding full agonists, one of the largest observed in the glutamate receptor family. PMID: 18658129
- Mutations to GLUR6 binding pocket that selectively affect domoate binding are freported. PMID: 18664604
- nonconserved residues in GluR6 define the size of the agonist-binding pocket, exerting a steric influence on the bound agonist and the extent of binding-domain closure PMID: 18690046
- GluR6 C-terminal domain KRIP6 regulates kainate receptors by inhibiting PICK1 modulation via competition or a mutual blocking effect PMID: 18692513
- in silico ligand-docking predicted that most partial agonists select for the closed and not, as expected, the open or intermediate conformations of the GluK2 agonist binding domain. PMID: 19225180
- Results indicate that ions can contribute substantial free energy to active state stabilization in GluR6, and provide quantitative measurements of the energetic consequences of allosteric ion binding to a ligand-gated ion channel. PMID: 19617541
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相關疾病：Mental retardation, autosomal recessive 6 (MRT6)
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亞細胞定位：Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
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蛋白家族：Glutamate-gated ion channel (TC 1.A.10.1) family, GRIK2 subfamily
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組織特異性：Expression is higher in cerebellum than in cerebral cortex.
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數據庫鏈接：
