GPD1 Antibody

說(shuō)明書(shū)

中文名稱：

GPD1兔多克隆抗體
貨號(hào)：

CSB-PA009709HA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA009709HA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA009709HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) GPD1 Polyclonal antibody
Uniprot No.：

P21695
基因名：

GPD1
別名：

AI747587 antibody; cytoplasmic antibody; EC 1.1.1.8 antibody; FLJ26652 antibody; G3PD antibody; Gdc-1 antibody; Gdc1 antibody; Gdp1 antibody; Glycerol 3 phosphate dehydrogenase 1 antibody; Glycerol 3 phosphate dehydrogenase cytosolic antibody; Glycerol 3 phosphate dehydrogenase soluble antibody; Glycerol-3-phosphate dehydrogenase [NAD+] antibody; Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic antibody; Glycerol-3-phosphate dehydrogenase 1 (soluble) antibody; Glycerol-3-phosphate dehydrogenase antibody; Glycerol-3-phosphate dehydrogenase, soluble antibody; Glycerphosphate dehydrogenase antibody; GPD-C antibody; gpd1 antibody; Gpd1 protein antibody; Gpd3 antibody; GPDA_HUMAN antibody; Gpdc antibody; GPDH antibody; GPDH-C antibody; Gpdhc antibody; HTGTI antibody; KIAA4010 antibody; MGC93453 antibody; MGPD antibody; mKIAA4010 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic protein (1-349AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，GPD1 Antibody (CSB-PA009709HA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于GPD1 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA009709HB01HU	GPD1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA009709HC01HU	GPD1 Antibody, FITC conjugated
Biotin	CSB-PA009709HD01HU	GPD1 Antibody, Biotin conjugated	ELISA

克隆類(lèi)型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Has glycerol-3-phosphate dehydrogenase activity.
基因功能參考文獻(xiàn)：
1. To recognize this entity by considering GPD1 mutations in appropriate clinical settings. PMID: 27368975
2. Although these data indicate that a lack of GPD1 inhibits gluconeogenesis from glycerol, chronic GPD1 deficiency may induce an adaptation that enhances gluconeogenesis from glycogenic amino acids PMID: 27733253
3. The R269A mutation of GPDH1 results in a 110-fold increase in K(m) (2.8 kcal/mol effect) and a 41,000-fold decrease in k(cat) (6.3 kcal/mol effect), which corresponds to a 9.1 kcal/mol destabilization of the transition state. PMID: 25884759
4. massive hepatomegaly, fatty liver and severe hypertriglyceridemia carrying a compound heterozygous mutation in GPD1 PMID: 24549054
5. Mutation analysis revealed a homozygous splicing mutation, c.361-1G>C, which resulted in an aberrantly spliced mRNA in the ten affected individuals. PMID: 22226083
6. The expression levels of the GPD1 gene did not differ between patients with OSA and their matched controls. The results were not affected by the clinical and biochemical measurements, the sleep parameters or the severity of nocturnal hypoxemia. PMID: 20404019
7. Identification and function of mutations in FAD-binding domain of mitochonrial glycerophosphate dehydrogenase in caucasians with type 2 diabetes mellitus. PMID: 11822825
8. GPD1 has a role in increased triacylglycerol production in adipose tissue of obese humans PMID: 14674682
9. The apoenzyme structure of GPD1 has been determined; an electrophilic catalytic mechanism by the epsilon-NH3+ group of Lys204 is proposed on the basis of structural analyses. PMID: 16460752
10. GpD1 is a weight-loss-responsive gene in skeletal muscle. Its observed transcriptional modulation may decrease triglyceride synthesis, with weight loss. PMID: 16849634
11. The activities of glycerol phosphate dehydrogenase were decreased by 73% in pancreatic islets of patients with type 2 diabetes. PMID: 19296078
12. the discovery overexpression of GPD1 and RRBP1 proteins and lack of expression for HNRNPH1 and SERPINB6 proteins which are new candidate biomarkers of colon cancer. PMID: 19425502
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相關(guān)疾病：

Hypertriglyceridemia, transient infantile (HTGTI)
亞細(xì)胞定位：

Cytoplasm.
蛋白家族：

NAD-dependent glycerol-3-phosphate dehydrogenase family
組織特異性：

Expressed in liver (at protein level).
數(shù)據(jù)庫(kù)鏈接：

HGNC: 4455

OMIM: 138420

KEGG: hsa:2819

STRING: 9606.ENSP00000301149

UniGene: Hs.524418

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