GMNN Antibody
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中文名稱：GMNN兔多克隆抗體
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貨號(hào)：CSB-PA009577GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：GMNN
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別名：DNA replication inhibitor antibody; Gem antibody; GEMI_HUMAN antibody; Geminin antibody; Geminin DNA replication inhibitor antibody; GMNN antibody; OTTHUMP00000039393 antibody; RP3 369A17.3 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human GMNN
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.
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基因功能參考文獻(xiàn)：
- High Geminin expression is associated with triple negative breast cancers. PMID: 26989079
- these data identify DUB3 and USP7 as factors that regulate DNA replication by controlling Geminin protein stability, and suggest that USP7 may be involved in Geminin dysregulation during breast cancer progression. PMID: 28288134
- geminin selectively couples the transcription factor forkhead box O3 (FoxO3) to HDAC3, thereby specifically facilitating FoxO3 deacetylation. PMID: 28436938
- summarize current information on the molecular functions of Geminin and the regulatory system for Geminin protein expression, and argue for the molecular role of Geminin in cell fate determination of hematopoietic stem cells [review] PMID: 27422432
- Studies indicate that geminin expression is associated with different types of cancer. PMID: 27702582
- High geminin expression is associated with breast cancer. PMID: 25082658
- De novo GMNN mutations cause autosomal-dominant primordial dwarfism associated with Meier-Gorlin syndrome. PMID: 26637980
- Elevated Ki67 and geminin expression distinguish a fraction of metastatic breast carcinoma with worse prognosis. PMID: 25595275
- geminin is indispensable for fetal hematopoiesis and regulates the generation of a physiological pool of stem and progenitor cells in the fetal hematopoietic system. PMID: 25516969
- These findings suggest that E2F-mediated activation of Geminin transcription is negatively regulated by Geminin through the inhibition of chromatin remodeling. PMID: 24554762
- Bound Geminin prevents transition of the pre-replicative complexes to a state that is competent for initiation of DNA replication. PMID: 25231993
- Selective expression of geminin during the proliferative phase of the cell cycle and its nuclear specificity increase its potential to be used as an alternative marker of proliferation in breast cancer patients. PMID: 24292956
- Protein levels of Geminin and Cdt1 are tightly regulated through the cell cycle, and the Cdt1-Geminin complex likely acts as a molecular switch that can enable or disable the firing of each origin of replication. PMID: 22918581
- The Aurora-A-geminin-Cdt1 axis represents a critical regulator of proper DNA replication. PMID: 23695679
- The properties of the Idas-Geminin complex suggest it as the functional form of Idas and provide a possible mechanism to modulate Geminin activity PMID: 24064211
- Human geminin, when expressed in human cells in culture under a constitutive promoter, is excluded from the nucleus during part of the G1 phase and at the transition from G0 to G1. PMID: 23814078
- MCM 7, geminin and topo IIalpha can be reliable tools for the differential diagnosis of reactive mesothelial cells and malignant mesothelioma cells. PMID: 23860238
- Data indicate that retroviral transduction-mediated overexpression or siRNA-mediated knock-down of Hoxa9 respectively down-regulated or up-regulated Geminin in hematopoietic cells. PMID: 23326393
- Coincidently amplified CDK13, GMNN, and CENPF genes can play a role as common cancer-driver genes in human cancers. PMID: 22912832
- p53 not only regulates cell-cycle progression, but also functions through geminin to prevent DHFR amplification and protect genomic integrity. PMID: 23026135
- Data suggest that pulmonary metastasis is corrected with levels of Geminin, cleaved caspase-3, CD44, E-cadherin, epidermal growth factor receptor, and CD204 in cancer cells within permeated lymphatic vessels. PMID: 22429811
- If cell cycle checkpoints are inhibited in cells lacking geminin, cells progress through mitosis and less re-replication occurs. PMID: 22366459
- found that geminin and TopoIIalpha interact primarily in G2/M/early G1 cells on chromosomes, that geminin recruits TopoIIalpha to chromosomal decatenation sites or vice versa and that geminin silencing in mammary epithelial cells triggers formation of chromosome bridges by suppressing TopoIIalpha access to chromosomal arms PMID: 21595939
- The C-terminal residue Ser184 of Geminin can be phosphorylated by Casein kinase II, resulting in the enhanced binding to Hox and more potent inhibitory effect on Hox transcriptional activity. PMID: 22615398
- geminin is a genuine oncogene that promotes cytokinesis failure and production of aneuploid, aggressive breast tumors when overexpressed PMID: 22184288
- The over-expression of geminin and cdt1 may play an important role in pathogenesis of acute leukemia. PMID: 21729526
- Geminin has been shown to coordinate proliferation and differentiation by regulating cell cycle progression, chromatin organization, and transcription in the nervous system. (Review) PMID: 21740351
- Idas as a novel Geminin binding partner, implicated in cell cycle progression, and a putative regulator of proliferation-differentiation decisions during development. PMID: 21543332
- Geminin enhances the binding of HDAC11 to Cdt1 and inhibits Cdt1-induced chromatin decondensation. PMID: 20980834
- Geminin expression is potentially a useful marker for predicting tumour aggressiveness and clinical outcome in salivary gland carcinomas. PMID: 20497246
- Data show that the Cdt1:Geminin complex can exist in two distinct forms, a "permissive" heterotrimer and an "inhibitory" heterohexamer. PMID: 19906994
- Results show that geminin, cdt1 and cdc6 are differentially regulated during megakaryocytic differentiation and suggest an active role of cdc6 in endomitosis. PMID: 12429841
- elevated levels in human cytomegalovirus infected fibroblasts PMID: 12551974
- Expression and phosphorylation of geminin. PMID: 12745091
- geminin does not have a role in Cdk-phosphorylation/negative regulation of Cdt1 PMID: 14993212
- Inactivation of Geminin, an inhibitor of origin licensing, leads to rereplication in human normal and tumor cells within the same cell cycle. PMID: 15159417
- Geminin is both a negative and positive regulator of pre-replicative complex formation in human cells, playing a positive role in allowing DNA replication factor Double parked accumulation in G2-M PMID: 15257290
- Data suggest that geminin is required for suppressing overreplication in cells with wild-type or mutant p53 and that a G(2)/M checkpoint restricts the proliferation of cells with overreplicated DNA. PMID: 15282313
- in proliferating HeLa cells geminin and Cdt1 are co-expressed during a relatively short time at the G(1)-to-S phase transition; Cdt1 is rapidly degraded early in S phase, but geminin remains bound to the chromatin sites PMID: 15284237
- In situ hybridization and immunohistochemistry localize Cdt1 as well as geminin to the proliferative compartment of the developing mouse gut epithelium PMID: 15291814
- Results describe the crystal structure of the coiled-coil domain of human geminin, and give a consistent identification and mapping of geminin interacting regions onto structurally important domains. PMID: 15313623
- expression of geminin is frequently deregulated in tumor cells and might play an important role in the regulation of cell growth in both normal and malignant cells. PMID: 15389519
- Geminin expression is severely downregulated upon differentiation of Caco-2 cells, an in vitro model of intestinal epithelial differentiation. PMID: 16273206
- The activity of Gem in regulating cell fate, in addition to its cell-cycle-regulatory activity, requires control of its subcellular localization. PMID: 16464175
- The combination of MCM2, geminin and Ki67 could represent a valuable tool in the understanding of hepatocellular carcinoma progression in cirrhosis. PMID: 16629645
- Findings suggest that the CDT1 838G/A and GMNN 387C/A polymorphisms may not play a major role in the etiology of breast cancer. PMID: 17029205
- Geminin is cleaved in primary cells and cancer cell lines induced to undergo apoptosis by a variety of stimuli. PMID: 17261582
- ATR/Chk1 pathway is activated at an early time point after the loss of Geminin and contributes to checkpoint arrest PMID: 17716975
- These results suggested that, at least in vitro, oleic acid-containing cell membranes of the lipid bilayer inhibit Cdt1-geminin complex formation by binding to Cdt1 and thereby liberating Cdt1 from inhibition by geminin. PMID: 18288374
- geminin is overexpressed in human pancreatic cancer and downregulated by apigenin which may contribute to the antitumor effect of this natural flavonoid PMID: 18404646
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相關(guān)疾病：Meier-Gorlin syndrome 6 (MGORS6)
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亞細(xì)胞定位：Cytoplasm. Nucleus.
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蛋白家族：Geminin family
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