FBXW2 Antibody, HRP conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) FBXW2 Polyclonal antibody
Uniprot No.：

Q9UKT8
基因名：

FBXW2
別名：

F box and WD 40 domain containing protein 2 antibody; F box and WD repeat domain containing 2 antibody; F box and WD40 domain protein 2 antibody; F box/WD repeat containing protein 2 antibody; F-box and WD-40 domain-containing protein 2 antibody; F-box/WD repeat-containing protein 2 antibody; FBW 2 antibody; FBW2 antibody; FBXW 2 antibody; Fbxw2 antibody; FBXW2_HUMAN antibody; Fwd2 antibody; Md6 antibody; Protein MD6 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human F-box/WD repeat-containing protein 2 protein (72-340AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
基因功能參考文獻：
1. BTrCP-FBXW2-SKP2 axis forms an oncogene-tumour suppressor-oncogene cascade to control cancer cell growth with FBXW2 acting as a tumour suppressor by promoting SKP2 degradation. PMID: 28090088
2. RACK1 competes with GCM1 for FBW2 and thereby prevents GCM1 ubiquitination, which is also supported by the observation that GCM1 is destabilized in RACK1-knockdown BeWo placental cells PMID: 23651062
3. the SCF(hFBW2) E3 complex has a key role in targeting hGCMa to the ubiquitin-proteasome degradation system PMID: 15640526
4. UBE2D2 is required for GCMa ubiquitination and for association with the SCF(FBXW2) complex. PMID: 18703417
數據庫鏈接：

HGNC: 13608

OMIM: 609071

KEGG: hsa:26190

STRING: 9606.ENSP00000363036

UniGene: Hs.494985

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