DTX1 Antibody

中文名稱：

DTX1兔多克隆抗體
貨號：

CSB-PA773055LA01HU
規格：

￥440
圖片：
Immunofluorescent analysis of Hela cells using CSB-PA773055LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) DTX1 Polyclonal antibody
Uniprot No.：

Q86Y01
基因名：

DTX1
別名：

Deltex 1; E3 ubiquitin ligase antibody; Deltex antibody; Deltex homolog 1 (Drosophila) antibody; Deltex homolog 1 antibody; Deltex protein 1 antibody; Deltex-1 antibody; Deltex1 antibody; dtx1 antibody; DTX1_HUMAN antibody; E3 ubiquitin protein ligase DTX1 antibody; E3 ubiquitin-protein ligase DTX1 antibody; FXI-T1 antibody; Fxit 1 antibody; Fxit1 antibody; hDTX1 antibody; hDx 1 antibody; mDTX1 antibody; Protein deltex 1 antibody; Protein deltex-1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human E3 ubiquitin-protein ligase DTX1 protein (261-410AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，DTX1 Antibody (CSB-PA773055LA01HU)，的標記方式是Non-conjugated。對于DTX1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA773055LB01HU	DTX1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA773055LC01HU	DTX1 Antibody, FITC conjugated
Biotin	CSB-PA773055LD01HU	DTX1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
基因功能參考文獻：
1. Deltex-1 mutations predict poor survival in diffuse large B-cell lymphoma PMID: 28183850
2. PI5P4Kgamma positively regulates the DTX1-mediated Notch pathway by promoting receptor recycling PMID: 29440432
3. Data indicate that decreased expression of deltex E3 ubiquitin ligase 1 (DTX1) in head and neck squamous cell carcinoma (HNSCC) tumors maybe associated with NOTCH pathway activation and increased migration potential. PMID: 28146432
4. Two SNPs (rs2384077 and rs10744794) in an intron of DTX1 and the linkage disequilibrium (LD) block are significantly associated with the immune response to HBV vaccination. PMID: 26894927
5. this study reports the identification of two new hGIP-interacting partners, DTX1 and STAU1. PMID: 23395680
6. characterization of two genes expressed in centroblasts of human tonsils: deltex (Drosophila) homolog 1 (DTX1), which is related to the Notch pathway and a new Kelch-like protein, KLHL6 PMID: 12617994
7. It is reported that BBAP and the human family of DTX proteins (DTX1, DTX2, and DTX3) function as E3 ligases based on their capacity for self-ubiquitination. PMID: 12670957
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亞細胞定位：

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear.
蛋白家族：

Deltex family
組織特異性：

Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells.
數據庫鏈接：

HGNC: 3060

OMIM: 602582

KEGG: hsa:1840

STRING: 9606.ENSP00000257600

UniGene: Hs.372152

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