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中文名稱：Cd74兔多克隆抗體
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貨號：CSB-PA004956LA01RA
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規(guī)格：￥440
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圖片：
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Western blot
All lanes: Cd74 antibody at 2µg/ml + Mouse lung tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 32, 25 kDa
Observed band size: 32 kDa
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Rattus norvegicus (Rat) Cd74 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Cd74 antibody; H-2 class II histocompatibility antigen gamma chain antibody; Ia antigen-associated invariant chain antibody; Ii antibody; MHC class II-associated invariant chain antibody; CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide antibody; CLIP)] antibody
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宿主：Rabbit
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反應種屬：Rat, Mouse
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免疫原：Recombinant Rat H-2 class II histocompatibility antigen gamma chain protein (57-280AA)
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免疫原種屬：Rattus norvegicus (Rat)
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標記方式：Non-conjugated
本頁面中的產(chǎn)品，Cd74 Antibody (CSB-PA004956LA01RA)，的標記方式是Non-conjugated。對于Cd74 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應用范圍：ELISA, WB
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44.; Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.; Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs).
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基因功能參考文獻：
- cytokine MIF was able to elicit inflammatory response of astrocytes through interaction with CD74 receptor, and activation of ERK was necessary for the intracellular signal transduction. PMID: 27926507
- Methylglyoxal induced gene expression of CD74 in the in the diabetic retina. PMID: 24974304
- Macrophage migration inhibitory factor(MIF)/CD74 interaction induces upregulation of cyclooxygenase (COX)-2 and prostaglandin E2 secretion in primary rodent microglia. PMID: 21802455
- Data indicate that intraluminal macrophage migration inhibitory factor, released from urothelial cells as a consequence of substance P treatment, interacts with urothelial cell-surface CD74. PMID: 19325914
- Intraluminal blockade of cell-surface CD74 and glucose regulated protein 78 prevents substance P-induced bladder inflammatory changes in the rat PMID: 19503733
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亞細胞定位：[Isoform Long]: Late endosome. Lysosome.; Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome.
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數(shù)據(jù)庫鏈接：
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