CXCL16 Antibody
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中文名稱：CXCL16兔多克隆抗體
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貨號(hào)：CSB-PA964027
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規(guī)格：￥1100
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圖片：
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Western Blot
Positive WB detected in: A549 whole cell lysate, SY5Y whole cell lysate
All lanes: CXCL16 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 28 kDa
Observed band size: 28 kDa
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：C-X-C motif chemokine 16 antibody; Chemokine (C X C motif) ligand 16 antibody; Chemokine; CXC motif; ligand 16 antibody; CXC chemokine ligand 16 antibody; Cxcl16 antibody; CXCLG16 antibody; CXL16_HUMAN antibody; Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein antibody; SCYB16 antibody; Small inducible cytokine B16 precursor antibody; Small-inducible cytokine B16 antibody; SR-PSOX antibody; SRPSOX antibody; Transmembrane chemokine CXCL16 antibody; UNQ2759/PRO6714 antibody
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反應(yīng)種屬：Human
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免疫原：Human CXCL16
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis. Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
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基因功能參考文獻(xiàn)：
- demonstrate that macrophages can promote the migration and invasion of ovarian carcinoma cells by affecting the CXCL16/CXCR6 pathway PMID: 30049511
- activation of cancer-associated fibroblasts and expression of CXCL16, shown to be a monocyte chemoattractant. PMID: 27725631
- Enhanced CXCL16 expression in lung cancer tissue promoted the proliferation and invasion of lung cancer cells. CXCL16 might promote proliferation and invasion of lung cancer by regulating the NF-kappaB pathway. PMID: 29353287
- increased plasma sCXCL16 might be implicated in the pathogenesis of immune thrombocytopenia and have a relationship with Th1/Th2 imbalance. PMID: 28886489
- Serum CXCL16 levels are significantly increased in patients with gallstone, and are independently associated with liver injury in Chinese population, suggesting that CXCL16 may be a biomarker of liver injury in subjects with gallstone or NAFLD. Hepatic CXCL16 mRNA and protein levels were also significantly increased in gallstone patients PMID: 28722105
- IFN-gamma, CXCL16 and uPAR are promising as effective biomarkers of disease activity, renal damage, and the activity of pathological lesions in systemic lupus erythematosus. PMID: 28628472
- Data showed that reverse signaling via CXCL16 promotes migration in CXCL16-expressing melanoma and glioblastoma cells, but does not affect proliferation or protection from chemically-induced apoptosis. PMID: 28698473
- Study showed, for the first time, highly significant relationships of circulating CXCL16 level with cardiac injury markers in dialysis patients. PMID: 28633141
- Women with gestational diabetes mellitus and preeclampsia had a dysregulated CXC chemokine ligand 16 during pregnancy, and in gestational diabetes mellitus, the increase in CXC chemokine ligand 16 early in pregnancy and after 5 years was strongly associated with their lipid profile. PMID: 28856928
- Data suggest that primary cells from papillary renal cell carcinoma secrete the chemokines IL8, CXCL16, and chemerin; these chemokines attract primary human monocytes and induce shift/transdifferentiation in monocytes toward M2 macrophage/foam cell phenotype. (IL8 = interleukin-8; CXCL16 = C-X-C motif chemokine ligand 16) PMID: 28759013
- Our study demonstrated that CXCL16-CXCR6 mediates CD8(+) T-cell skin trafficking under oxidative stress in patients with vitiligo, and CXCL16 expression in human keratinocytes induced by ROS is, at least in part, caused by unfolded protein response activation PMID: 27826097
- eGFR and serum albumin had an independent and significant negative correlation with plasma CXCL16 in diabetic kidney disease. PMID: 27665581
- The expression of CXCL16 and and its receptor, CXCR6, their immunolocalization in disc tissue and their presence following exposure of cultured human annulus fibrosus cells to proinflammatory cytokines are reported. PMID: 27869573
- Inflammation contributed to foam cell formation in the radial arteries of ESRD patients via activation of the CXCL16/CXCR6 pathway, which may be regulated by P2X7R. PMID: 27877078
- CXCL16 single nucleotide polymorphisms significantly impacted myocardial infarction risk in a Chinese Han population. PMID: 28286356
- Transmembrane-CXCL16 specifically acts as a receptor for soluble-CXCL16 in human meningioma cells. PMID: 27784296
- Higher levels CXCL16 may be a biomarker for predicting stroke incidence and might contribute to plaque destabilization. PMID: 27355560
- CXCL16 is released into the circulation as a result of cardiac surgery and that high post-operative CXCL16 levels are associated with an increased severity of post-operative organ dysfunctions. PMID: 26499307
- Serum CXCL16 may be a novel biomarker for the diagnosis of patients with diabetic coronary artery disease. PMID: 27098626
- High CXCL16 expression is associated with prostate cancer. PMID: 26799186
- In conclusion, rheumatoid arthritis synovial fibroblasts were activated by CXCL16 to produce RANKL via pathways involving JAK2/STAT3 and p38/MAPK PMID: 26621504
- Our data suggest that CXCL16 induces angiogenesis in autocrine manner via ERK, Akt, p38 pathways and HIF-1alpha modulation PMID: 26707275
- Cell proliferation enhancing and anti-apoptosis activity requires the intracellular domain and apparently the dimerization of the transmembrane chemokine ligand. PMID: 26796342
- Wnt5a-Ror2 signaling enhances expression and secretion of CXCL16 in mesenchymal stem cells thereby activating CXCR6 expressed on tumor cells to promote proliferation. PMID: 26708384
- Endothelial CXCL16's action on platelets is not limited to platelet activation. Immobilised CXCL16 also acts as a potent novel platelet adhesion ligand, inducing platelet adhesion to the human vessel wall. PMID: 25904061
- HMGB-1, CXCL16, miRNA-30a, and urinary TGF-ss1 were highly expressed in PNS patients and may play important roles in the pathogenesis and development of PNS. PMID: 26345917
- high protein expression of CXCL16 and high protein co-expression of CXCL16/CXCR6 in prostate cancer were independent predictors for a worse clinical outcome PMID: 26272362
- PPARG rs1152002, AGTR1 rs5186, CXCL16 rs3744700 and LGALS2 rs7291467 polymorphisms may be closely related to the development of coronary heart disease PMID: 26045830
- These results indicate that MEK inhibitor diminishes Nasopharyngeal carcinoma cell proliferation and NPC-induced osteoclastogenesis via modulating CCL2 and CXCL16 expressions. PMID: 26058873
- we examined the expression of CXCL16 and CXCR6 and their relations to prognosis in 335 unselected patients with NSCLC, and investigated possible relationships with our previously studied immunologic and angiogenic markers PMID: 26021984
- CXCL16 T123V181 haplotype is a moderate genetic risk factor for the development of carotid plaque. PMID: 25142184
- Serum CXCL16 is increased in severe pancreatitis with infected pancreatic necrosis and identifies patients who benefit from surgical necrosectomy PMID: 25661686
- injured hepatocytes up-regulated CXCL16 expression, indicating that scavenging functions of CXCL16 might be additionally involved in the pathogenesis of NAFLD. PMID: 25372401
- CXCL16 and CXCR6 coexpression is associated with invasiveness of lung cancer. PMID: 24897301
- No significant association of the CXCL16 polymorphism was established either with soluble CXCL16 plasma levels or with clinical parameters and course of multiple sclerosis. PMID: 24854635
- CXCL16 expression is enhanced in inflammatory cardiomyopathy and is an independent predictor of death in patients with heart failure. PMID: 25223819
- Elevated serum sCXCL16 levels were discovered in the systemic lupus erythematosus patients with cutaneous and renal involvement. PMID: 25015061
- Silencing CXCL16 could phenocopy the effects of miR-451 on phenotypes of osteosarcoma cells. PMID: 25391425
- High circulating CXCL16 levels are associated to human kidney and cardiovascular disease and urinary CXCL16 may increase in kidney injury. PMID: 24861945
- Serum CXCL16 may be an indicator of renal injury in subjects with type 2 diabetes mellitus. PMID: 24489966
- Serum CXCL16 was increased in patients with active Primary nephrotic syndrome and correlated with blood lipids, urine protein and immune and inflammation responses PMID: 24460887
- High serum sCXCL16 is a prognostic marker for poor survival of OC patients, possibly reflecting ADAM-10 and ADAM-17 pro-metastatic activity. PMID: 24518602
- CXCL16, iNKT cell-associated cell marker Valpha24, and CD1d were significantly upregulated in esophageal biopsies from EoE patients and correlated with the expression of inflammatory mediators associated with allergy. PMID: 24513807
- CXCL16 could be a novel biomarker and potential predictor of disease activity in MS. PMID: 24069377
- CXCL16/CXCR6 interaction may play an important role in modifying the response of pDCs to environmental danger signals PMID: 24302814
- Our results suggest that the CXCL16/CXCR6 axis appears to be important in the progression of Ewing sarcoma family tumor PMID: 24507753
- Data suggest that plasma level of CXCL16 is up-regulated in subjects with metabolic syndrome and correlates with severity of carotid atherosclerosis (i.e., intima-media thickness and plaque index). PMID: 23398954
- Erythrocyte adhesion to immobilized platelets requires phosphatidylserine at the erythrocyte surface and CXCL16 as well as CD36 expression on platelets. PMID: 24284794
- CXCL16, inversely correlated with CD99 expression in Hodgkin Reed-Sternberg (H/RS) cells. PMID: 23743627
- Suggest that expression of transmembrane CXCL16 on surface of plasmacytoid dendritic cell might contribute to high serum IFN-alpha levels seen in patients with Behcet's disease. PMID: 24064021
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亞細(xì)胞定位：Cell membrane; Single-pass type I membrane protein. Secreted. Note=Also exists as a soluble form.
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蛋白家族：Intercrine alpha (chemokine CxC) family
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組織特異性：Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.
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