CHMP6 Antibody
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中文名稱：CHMP6兔多克隆抗體
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貨號：CSB-PA005366GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：Charged multivesicular body protein 6 antibody; chmp6 antibody; CHMP6_HUMAN antibody; Chromatin modifying protein 6 antibody; Chromatin-modifying protein 6 antibody; FLJ11749 antibody; hVps 20 antibody; hVps20 antibody; novel SNF7 protein antibody; OTTMUSP00000004363 antibody; RGD1565325 antibody; RP24 225K18.4 antibody; Vacuolar protein sorting associated protein 20 antibody; Vacuolar protein sorting-associated protein 20 antibody; Vps 20 antibody; Vps20 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human CHMP6
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.
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基因功能參考文獻：
- Taken together, these data suggest an active role for ESCRT-II and CHMP6 in ESCRT-mediated abscission PMID: 25232011
- Purified VPS-20 exhibits an open extended conformation, irrespective of ESCRT-II binding. PMID: 25588614
- silencing CHMP6 and VPS4A also blocked epidermal growth factor receptor (EGFR) recycling PMID: 22231449
- In this study, we found that overexpression of chromatin modifying protein 6 (CHMP6) induced cell death by a series of experiments. PMID: 19270365
- Results describe the mapping of multivesicular bodies with the second winged helix domain of human ESCRT-II subunit VPS25 and the first helix of ESCRT-III subunit VPS20. PMID: 19686684
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亞細胞定位：Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane. Membrane; Lipid-anchor. Note=Localizes to endosomal membranes.
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蛋白家族：SNF7 family
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組織特異性：Ubiquitously expressed.
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數據庫鏈接：
