CGA Antibody

說明書

中文名稱：

CGA兔多克隆抗體
貨號：

CSB-PA292680
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA292680(CGA Antibody) at dilution 1/65, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA292680(CGA Antibody) at dilution 1/65, on the right is treated with fusion protein. (Original magnification: ×200)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P01215
基因名：

CGA
別名：

Anterior pituitary glycoprotein hormones common subunit alpha antibody; CG alpha antibody; CG-alpha antibody; cga antibody; Choriogonadotropin alpha chain antibody; Chorionic Gonadotrophin Alpha antibody; Chorionic Gonadotrophin Alpha Subunit antibody; Chorionic gonadotrophin subunit alpha antibody; chorionic gonadotropin, alpha polypeptide antibody; Follicle-stimulating hormone alpha antibody; Follicle-stimulating hormone alpha chain antibody; follicle-stimulating hormone alpha subunit antibody; Follitropin alpha antibody; Follitropin alpha chain antibody; FSH Alpha antibody; FSH-alpha antibody; FSHA antibody; GLHA_HUMAN antibody; Glycoprotein hormones alpha chain antibody; Glycoprotein Hormones Alpha Polypeptide antibody; GPH Alpha antibody; GPHa antibody; GPHA1 antibody; HCG antibody; hyrotropin alpha antibody; LH-alpha antibody; LHA antibody; LSH alpha antibody; LSH-alpha antibody; Luteinizing hormone alpha antibody; Luteinizing hormone alpha chain antibody; Lutropin alpha antibody; Lutropin alpha chain antibody; Thyroid Stimulating Hormone Alpha antibody; Thyroid Stimulating Hormone Alpha Chain antibody; Thyroid-stimulating hormone alpha chain antibody; Thyrotropin alpha chain antibody; TSH Alpha antibody; TSH-alpha antibody; TSHA antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Fusion protein of Human CGA
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.
基因功能參考文獻：
1. This study which performed for the first time in Iran suggests that polymorphism in CGA gene can affect male infertility. PMID: 29627965
2. Our findings support a model in which CREB3L1 acts as a downstream effector of TSH to regulate the expression of cargo proteins, and simultaneously increases the synthesis of transport factors and the expansion of the Golgi to synchronize the rise in cargo load with the amplified capacity of the secretory pathway PMID: 29093023
3. men with higher and women with lower serum TSH levels are at increased risk of frailty. PMID: 27869535
4. Inhibin-B secretion and FSH isoform distribution may play an integral part of follicular selection in the natural menstrual cycle. (Review) PMID: 27756855
5. proteomic study reveals unique protein changes in both cellular (98% unique identifications) and secreted (96% unique identifications) proteins in the transition to the progesterone-dominated secretory (receptive) phase and subsequently to pregnancy, mediated by embryo-derived human chorionic gonadotropin (hCG) PMID: 27262222
6. the in vivo bioactivities of FSH glycoforms in Fshb null mice using a pharmacological rescue approach, was investigated. PMID: 27561202
7. In girls with central precocious puberty, increased body mass index (BMI) was associated with slightly lower peak stimulated luteinizing hormone (LH) levels at early pubertal stages (Tanner stages 2 and 3). PMID: 27215137
8. the distribution of 1(st) trimester TSH and evaluate its association with perinatal outcomes and future development of maternal thyrotoxicosis, is reported. PMID: 27351808
9. The present results have for the first time shown protective effects exerted by hCG on vascular endothelial function. PMID: 26279419
10. Human chorionic gonadotropin provides a mechanism to bridge embryo to endometrium through beta1,4-GalT. PMID: 26191157
11. thyroid-stimulating hormone elevations can obviously be the initial finding in pseudohypoparathyroidism type Ib patients. PMID: 25403028
12. TBP attenuates Msx1-mediated glycoprotein hormone alpha transcriptional repression. PMID: 26505791
13. The results indicate that gal-3 might be regulated by Human chorionic gonadotropin (hCG)in preparing the endometrium for embryonic implantation. PMID: 21705042
14. Limitations in the process of transcription and translation inhibit recombinant human chorionic gonadotropin expression in CHO cells. PMID: 25529346
15. the 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR)-induced activation of AMPK directly inhibited the expression of SREBP-2 and HMGCR and HMGCS, and suppressed the TSH-stimulated up-regulation of SREBP-2 in HepG2 cells. PMID: 25933205
16. Serum TSH was associated with pulse wave velocity on population level when adjusted with age and sex. PMID: 25185682
17. A single low TSH at baseline was associated with increased risk of hip fractures (adj HR 1.16, 95% CI 1.07-1.26, p < 0.001) but not major osteoporotic fractures (MOF, adj HR 1.06, 95% CI 0.99-1.12, p = 0.058) over a median follow-up of 7.5 years. PMID: 24723381
18. This study showed a link between low maternal serum hCG levels and cryptorchidism in boys from uncomplicated pregnancy. PMID: 25064170
19. A protective effect of hCG against breast cancer may be associated with its growth inhibitory and differentiation induction function in breast cancer cells. PMID: 24753159
20. LH, progesterone, and TSH can stimulate aldosterone. PMID: 24297486
21. Elevated total hCG and free beta-hCG concentrations during early pregnancy are associated with nonstatistically significant reductions in maternal risk of breast cancer. PMID: 24559445
22. chromogranin A PMID: 23153859
23. The purpose of these studies was to determine if CTNNB1's contribution to FSH-mediated steroidogenesis in primary rat granulosa cells was due in part to extracellular stimulation of the canonical WNT signaling pathway. PMID: 24466091
24. Hypo-glycosylated human follicle-stimulating hormone is much more active in vitro than its fully-glycosylated counterpart. PMID: 24291635
25. New information about TSH signaling in human differentiated adipocytes, and add to the evidence that TSH is a pro-inflammatory stimulus of adipocytes. PMID: 24661543
26. Human chorionic gonadotropin hormone stimulates trophoblast invasion independently of the hCG receptor. PMID: 23684886
27. data further identified a complex interaction between IL1 and hCG, which, despite a synergistic action on several significant endometrial target genes, may encompass a tight control of endogenous IL1 and extends to other IL1 family members PMID: 23717664
28. Msx1 functions as a negative regulator early in pituitary development by repressing the gonadotrope-specific alphaGSU and GnRHR genes. PMID: 23371388
29. BK(Ca) is a crucial part of the signaling cascade of LH/hCG in Leydig cells. PMID: 23267835
30. In our multi-ethnic cohort of euthyroid obese children and adolescents increasing TSH was associated with impaired glucose metabolism and dyslipidemia. PMID: 23525871
31. Data indicate that neither serum inhibin B nor follicle-stimulating hormone (FSH) is a suitable surrogate for determination of sperm concentration in a semen sample. PMID: 23423746
32. Ser680 genotype for FSHR is a factor of relative resistance to FSH stimulation resulting in slightly higher FSH serum levels, thus leading to a prolonged duration of the menstrual cycle. PMID: 23380184
33. The use of these age-specific reference intervals for TSH, especially in those over 70 years old, would result in the reclassification of many TSH results from "abnormal" to "normal" and avoid unnecessary treatment. PMID: 23345094
34. hCG coordinates embryonic signal interaction with the maternal endometrium and may promote embryonic growth. PMID: 22811570
35. N-acetyl-L-cysteine modulates multiple signaling pathways to rescue male germ cells from apoptosis induced by chorionic gonadotropin. PMID: 22354444
36. Data suggest that in embryonic stem cells [which express proto-oncogene c-ETS-2 (ETS2) but not CGA], ETS2 does not occupy its binding site on CGA promoter but is found instead as soluble complex with POU5F1 (Oct3 transcription factor). PMID: 22446105
37. low urinary level of hyperglycosylated hCG is associated with pregnancy failure PMID: 22386126
38. second-trimester maternal serum levels of alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estriol may have a role in bronchopulmonary dysplasia PMID: 22391642
39. Data suggest that a progressive increase in TSH are predictive factors for thyroid failure in Hashimoto's thyroiditis (HT) patients. PMID: 21981142
40. Data suggest that likelihood of papillary thyroid carcinoma is reduced when serum TSH is lower, as in thyroid autonomy, and increased when serum TSH is higher, as in thyroid autoimmunity. [Meta-Analysis; REVIEW] PMID: 22278420
41. TSH showed significant positive correlation with creatinine and uric acid values and, thyroid function test had a negative correlation with uric acid in overt hypothyroidism. PMID: 22061337
42. Serum IL-6, IL-1beta and hCG levels were significantly increased in women with pre-eclampsia compared to controls. PMID: 21623995
43. TSH-TSHR interaction through cAMP signaling (using thyrogen/rTSHalpha) is involved in differentiation/gene expression regulation of bone marrow-derived mesenchymal stem cells; first evidence of expression of TSHR in stem cell plasma membrane. PMID: 22128326
44. investigation of hCG in seminal plasma: Level of free hCGa is reduced in infertility with abnormal semen analysis. In oligospermia, holo-hCG is low; hCGa is present as highly glycosylated large free subunit with a unique glycosylation pattern. PMID: 21838882
45. TSH is a novel neuroendocrine regulator of selected keratins in the human hair follicle PMID: 21763112
46. Increasing concentrations of FSH caused a biphasic dose-response, with a maximal (1.5-fold) increase in RANK(high) cells. PMID: 21159522
47. In euthyroid children without a history of hypo- or hyperthyroidism, increasing levels of TSH and decreasing levels of free T4 are associated with higher triglyceride levels and elevated markers of insulin resistance. PMID: 21114382
48. Results suggest that a serum TSH concentration at the lower end of the reference range may be associated with low BMD in men. PMID: 20455884
49. Findings demonstrate that FSH has dose-dependent anabolic effects on bone via an ovary-dependent mechanism. PMID: 21149714
50. Women with high TSH at end term are at risk for breech presentation. Substantial evidence for a relation between breech presentation and neurodevelopmental delay exists. PMID: 20718770
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亞細胞定位：

Secreted.
蛋白家族：

Glycoprotein hormones subunit alpha family
數據庫鏈接：

HGNC: 1885

OMIM: 118850

KEGG: hsa:1081

STRING: 9606.ENSP00000358595

UniGene: Hs.119689

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