CFB Antibody
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中文名稱：CFB兔多克隆抗體
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貨號：CSB-PA005268GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：AHUS4 antibody; B factor properdin antibody; BF antibody; BFD antibody; C3 proaccelerator antibody; C3 proactivator antibody; C3/C5 convertase antibody; CFAB antibody; CFAB_HUMAN antibody; CFB antibody; Complement Factor B antibody; Complement factor B Bb fragment antibody; FB antibody; FBI12 antibody; GBG antibody; Glycine rich beta glycoprotein antibody; Glycine-rich beta glycoprotein antibody; H2 Bf antibody; H2BF antibody; PBF2 antibody; Properdin factor B antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human CFB
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
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基因功能參考文獻：
- Study demonstrated that a novel complotype composed of CFB (rs4151667) in combination with CFB (rs641153) and CFH(rs800292) is strongly associated with complement activation and age-related macular degeneration status. PMID: 27241480
- target sequencing of age-related macular degeneration (AMD) susceptibility genes identified enrichment of low-frequency coding variants in CETP, C2 and CFB are associated with AMD susceptibility in the Japanese population PMID: 28173125
- Heterozygous variants in the CFB gene can be pathogenic and associated with immune-complex diffuse membranoproliferative glomerulonephritis and atypical hemolytic uremic syndrome PMID: 28210841
- The complement activation factors Bb, C3a, C5a, and MAC were increased significantly in early-onset severe pre-eclampsia (EOSPE) (all P<.01) and late-onset severe pre-eclampsia (LOSPE). (P value: .027, <.001, .001, and <.001, respectively) compared with E/L-control. C1q and C4d were increased significantly in LOSPE (P value: .003 and .014, respectively) compared with L-control. PMID: 27461873
- These results suggest (i) apparent allelic heterogeneity in CFB and genetic heterogeneity in SLC44A4 across different ethnic groups; (ii) shared ulcerative colitis genetic etiological factors among Asians PMID: 27759029
- Neutralization of the complement factor C3-dependent antichlamydial activity was dependent on the proteolytic activity of Chlamydia trachomatis CPAF and correlated with the CPAF-mediated degradation of complement factor C3 and factor B. PMID: 27436813
- Our results revealed a significant association of CFB with non-infectious uveitis, particularly predisposed to VKH disease. Genetic differences for uveitis could be gender-specific. PMID: 26671509
- There is a link between phenotype BF SS07 and allotype BF*S07 with aCl-IgM in systemic lupus erythematosus patients; BF*F allotype could be considered a marker of protection against the development of antiphospholipid antibodies in these patients. PMID: 26537423
- The Relationship of Longitudinal Levels of Complement Bb During Pregnancy with Preeclampsia PMID: 26510395
- P serum level expression could be a reliable clinical biomarker to identify patients with underlying surface alternative pathway C5 convertase dysregulation. PMID: 26660535
- CFB is downregulated in non-small cell lung cancer patients compared to those with benign lung disease or no lung disease. PMID: 26908325
- These results suggest that a maternal immune response through complement fB might play a role in the development of preeclampsia, particularly in African-American patients. PMID: 25604034
- mutation results in atypical hemolytic uremic syndrome PMID: 24906628
- individuals with the chronic hepatitis B (CHB) risk genotype CC of rs12614 had significantly lower CFB concentrations than those carrying one or two rs12614 T alleles (CT or TT carriers) both in normal populations and CHB patients PMID: 25802187
- Complement factor B is a novel biomarker candidate for pancreatic ductal adenocarcinoma. PMID: 25057901
- complement factor B has an important role in the etiology of familial C3 glomerulonephritis PMID: 25758434
- A mutation in complement factor B was associated with a case of C3 glomerulonephritis. PMID: 25532781
- The C2 and CFB gene variants were shown to be associated with polypoidal CNV. Typical PCV was not associated with variants in these genes. PMID: 24965207
- Complement factor B is potently upregulated locally in inflammatory bowel disease in addition to having a possible central role in systemic complement activation. PMID: 24739633
- studied the functional consequences of 10 FB genetic changes recently identified from different atypical hemolytic uremic syndrome cohorts PMID: 24652797
- The rs547154, rs641153, and rs12614 SNPs were not associated with age-related macular degeneration development in Greek patients. PMID: 24519512
- ARMS2 and C3 are major contributors to advanced age-related macular degeneration in Mexican patients, while the contributions of CFH, C2, and CFB are minor to those of other populations. PMID: 24453474
- The CFB (R32Q) polymorphism was associated with age-related macular degeneration characterized by small drusen only, and appeared to be protective of large drusen. PMID: 23373431
- we have assessed the relationship between GA and previously identified AMD-associated variants of genes (CFH, CFB, C3, FHR1, FRH3, and ARMS2/HTRA). PMID: 24557084
- Describe electroluminescent platform for profiling complement factor B in complement cascade activation. PMID: 24287422
- CFH-rs800292 and CFB-rs1048709 are associated with the presence of diabetic retinopathy, which strengthens the concept that complement system plays an important role in the pathogenesis of DR PMID: 23864767
- Eculizumab is effective therapy for atypical hemolytic uremic syndrome associated with factor B mutations. PMID: 23624872
- Gain of function mutation in factor B is associated with recurrence in adult renal transplant recipients with atypical hemolytic and uremic syndrome. PMID: 23356914
- Gene variants in CFH and C2/CFB contribute to age related macular degeneration in the Chinese population. PMID: 23233260
- CFH, ARMS2, and CFB AMD-risk alleles are consistently associated with the disease, even in ethnic groups with a complex admixture of ancestral populations such as Mexican mestizos. PMID: 23112567
- Increased activation of the alternative complement pathway in vitreous was controlled by disease stage and genetic variation in the complement pathway, supporting a role for complement activation in macular degeneration disease pathogenesis. PMID: 22930722
- This meta-analysis provides evidence for an association between C2/CFB polymorphisms and age-related macular degeneration. PMID: 22869612
- Our results revealed an association between Anterior uveitis and Complement Factor B-rs1048709. PMID: 22714898
- significantly increased levels in patients with antiphospholipid antibodies or primary antiphospholipid syndrome PMID: 22234447
- Women who were obese with levels of Bb or C3a in the top quartile were 10.0 (95% confidence interval, 3.3-30) and 8.8 (95% confidence interval, 3-24) times, respectively, more likely to develop preeclampsia compared with the referent group. PMID: 22542119
- In conclusion, the genetic effect of C2, CFB and C3 polymorphisms, which are known to be important for AMD in Caucasian, were not significant in the Korean population. PMID: 22273503
- C2/CFB variants play a protective role in the risk of developing neovascular AMD and PCV in the Japanese. PMID: 22232432
- This study did not detect an association between individual age-related macular degeneration risk genotypes and the putatively protective macular pigments, or serum concentrations of its constituent carotenoids PMID: 21816153
- Access to the complement factor B scissile bond is facilitated by association of factor B with C3b protein. PMID: 21862585
- the concept of a functional complotype (combination of C3(R102G), factor B (fB(R32Q), and factor H (fH(V62I) polymorphisms) in defining complement activity in an individual, influencing susceptibility to alternative pathway-driven disease. PMID: 21555552
- Complement factor B polymorphism 32W protects against age-related macular degeneration. PMID: 21541267
- the association with the known genetic susceptibility loci CFH, HTRA1, and AMRS2 were confirmed, and a risk-conferring polymorphism in one new locus, LRP5, was identified. PMID: 21282580
- These studies show that the acquisition of fH to the S. aureus surface inhibits complement-mediated opsonization via disruption of the alternative pathway convertase. PMID: 21163532
- CFB 32W (rs12614; T) protects against age-related macular degeneration compared to the common CFB 32R. The protective effect is less strong than CFB 32Q. Knowledge of both rs641153 and rs12614 is required to predict the amino acid at residue 32. PMID: 21541267
- Studies indicate that mutations or polymorphisms in complement genes C3 and factor B are genetic risk factors contributing hemolytic uremic syndrome. PMID: 20837143
- crystal structure of C3bB at 4 A and complex with factor D at 3.5 A; data show how factor B binding to C3b forms open "activation" state of C3bB; Factor D binds open conformation of factor B through a site distant from the catalytic center PMID: 21205667
- Reduced expression of alpha-2 macroglobulin and complement factor B was detected in sera of patients with nasopharyngeal carcinoma. PMID: 20575108
- This study showed that CFH was more likely to be age-related macular(AMD) susceptibility gene, and none of the other C2, CFB, and C3 genes were associated with AMD in a white population. PMID: 20523265
- The polypoidal choroidal vasculopathy (PCV) phenotype in Caucasian patients is associated with the major alleles/genotypes in the age-related macular degeneration (AMD)-associated loci, suggesting that PCV and AMD are genetically similar. PMID: 20378180
- Case Report: 8-year-old girl diagnosed with atypical hemolytic uremic syndrome (aHUS) with a complement factor B (CFB) gene mutation. PMID: 20108004
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相關疾病：Hemolytic uremic syndrome atypical 4 (AHUS4); Complement factor B deficiency (CFBD)
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亞細胞定位：Secreted.
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蛋白家族：Peptidase S1 family
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數據庫鏈接：
