CAMK2B Antibody

說明書

中文名稱：

CAMK2B兔多克隆抗體
貨號：

CSB-PA004466GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q13554
基因名：

CAMK2B
別名：

Calcium/calmodulin dependent protein kinase (CaM kinase) II beta antibody; Calcium/calmodulin dependent protein kinase II beta antibody; Calcium/calmodulin dependent protein kinase IIB antibody; Calcium/calmodulin dependent protein kinase type II beta chain antibody; calcium/calmodulin-dependent protein kinase II beta antibody; Calcium/calmodulin-dependent protein kinase type II subunit beta antibody; CAM 2 antibody; CaM kinase II beta chain antibody; CaM kinase II beta subunit antibody; CaM kinase II subunit beta antibody; CaM-kinase II beta chain antibody; CAM2 antibody; CAMK 2 antibody; CAMK 2B antibody; CaMK II beta subunit antibody; CaMK II subunit beta antibody; CaMK-II subunit beta antibody; CAMK2 antibody; CaMK2 beta antibody; Camk2b antibody; CAMKB antibody; CaMKII beta subunit antibody; CaMKIIB antibody; KCC2B_HUMAN antibody; MGC29528 antibody; Proline rich calmodulin dependent protein kinase antibody; proline rich calmodulin-dependent protein kinase antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human CAMK2B
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
基因功能參考文獻：
1. TGFbeta elevated the expression of CamK IIbeta and CamK IIdelta, while siRNA silencing of those two subtypes significantly reduced TGFbeta-mediated expression of collagen A1 and fibronectin 1. PMID: 28130256
2. Due to similarity of structure variations, we suggest that these compounds may have an effect on beta-CaMKII and that sengesterone may have a similar efficacy as the control. PMID: 25045698
3. beta-carotene reverses the IL-1beta-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells PMID: 22750393
4. Promoter methylations of CAMK2B and ARFGEF1 are novel epigenetic markers identified in breast cancer cell lines. PMID: 21871176
5. Study presents the crystal structure of an autoinhibited full-length human CaMKII holoenzyme, revealing an unexpected compact arrangement of kinase domains docked against a central hub, with the calmodulin-binding sites completely inaccessible. PMID: 21884935
6. The novel cGMP/PKG/ROS/calmodulin/CaMKII signaling pathway may regulate cardiomyocyte excitability by opening K(ATP) channels and contribute to cardiac protection against ischemia-reperfusion injury. PMID: 21479273
7. Four distinct isoforms of CAMKII were isolated. Two of them were characterized as CaMKII alpha and beta subunits.expression is developmentally regulated in both human fetal and adult brain to different degrees PMID: 11710563
8. CaMK II regulates c-FLIP expression and phosphorylation, thus modulating Fas-mediated signaling in glioma cells PMID: 12496285
9. exercise increases the activity of CaMKII in skeletal muscle, suggesting that it may have a role in regulating skeletal muscle function and metabolism during exercise in humans PMID: 14565989
10. presence of a CaMKIIbeta isoform that can target the SR presumably via its membrane anchor alphaKAP defines a previously unrecognized Ca2+/CaM regulatory system in myocardium PMID: 15792370
11. thrombomodulin induces Ca2+ signals and nitric oxide synthesis through EGFR and calmodulin kinase II PMID: 16126727
12. expression significantly elevated in frontal cortex in schizophrenia & depression; because CaMKIIbeta influences expression of neuroreceptors & neural outgrowth & pruning, altered expression in schizophrenia or depression may contribute to these diseases PMID: 16247765
13. regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII. PMID: 17419996
14. These FLIM versions of Camui could be useful for elucidating the function of CaMKII both in vitro and in vivo. PMID: 18302935
15. The expression of CaMKII beta was significantly elevated in schizophrenia and in depression. PMID: 16247765
16. mRNA levels are elevated in the frontal cortex in schizophrenia. PMID: 11042361
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亞細胞定位：

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Note=In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR.
蛋白家族：

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
組織特異性：

Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.
數據庫鏈接：

HGNC: 1461

OMIM: 607707

KEGG: hsa:816

STRING: 9606.ENSP00000379098

UniGene: Hs.351887

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