BLOC1S6 Antibody
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中文名稱：BLOC1S6兔多克隆抗體
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貨號：CSB-PA018150GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：BLOC1S6
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別名：Bloc1s6 antibody; iogenesis of lysosome-related organelles complex 1 subunit 6 antibody; PA antibody; Pallid (mouse) homolog antibody; PALLID antibody; Pallid protein antibody; Pallid protein homolog antibody; Pallidin antibody; Pallidin homolog (mouse) antibody; PLDN antibody; PLDN_HUMAN antibody; Syntaxin 13 binding protein antibody; Syntaxin 13-interacting protein antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human PLDN
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.
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基因功能參考文獻：
- Results from a study on gene expression variability markers in early-stage human embryos shows that BLOC1S6 (PLDN) is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
- PLDN is a direct target of RUNX1 and its dysregulation is a mechanism for platelet dense granule deficiency associated with RUNX1 haplodeficiency PMID: 28075530
- Mecp2 regulates the expression of components belonging to the dysbindin interactome PMID: 23750231
- role in biogenesis of lysosome-related organelles PMID: 12191018
- no defects in the known components of pallidin-muted complex (BLOC-1)have been identified in 142 patients with HPS, suggesting that BLOC-1 function may be critical in humans. PMID: 12576321
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相關疾病：Hermansky-Pudlak syndrome 9 (HPS9)
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亞細胞定位：Cytoplasm. Membrane; Peripheral membrane protein.
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蛋白家族：BLOC1S6 family
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組織特異性：Widely expressed.
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數據庫鏈接：
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