BLOC1S2 Antibody
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中文名稱：BLOC1S2兔多克隆抗體
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貨號：CSB-PA754307ESR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA754307ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA754307ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) BLOC1S2 Polyclonal antibody
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Uniprot No.：
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基因名：BLOC1S2
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別名：Biogenesis of lysosome-related organelles complex 1 subunit 2 antibody; BL1S2_HUMAN antibody; BLOC-1 subunit 2 antibody; Bloc1s2 antibody; BLOS2 antibody; Centrosome-associated protein antibody; RP11 316M21.4 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 2 protein (44-142AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May play a role in cell proliferation.
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基因功能參考文獻：
- WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells PMID: 20308062
- BLOC1S2 protein is widely expressed in normal tissue as well as in malignant tumors with a tendency towards lower expression levels in certain subtypes of tumors. Over-expression of BLOC1S2 in the presence or absence of HIPPI does not induce apoptosis. PMID: 18188704
- we have explored ways of efficiently gathering high-quality information about candidate binding partners fob bloc1s2 PMID: 19083121
- Biogenesis of lysosome-related organelles complex-1 (BLOC-1) subunit 2 (BLOS2).BLOC-1 is required for the biogenesis of melanosomes and platelet dense granules. PMID: 15102850
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亞細胞定位：Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Lysosome membrane.
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蛋白家族：BLOC1S2 family
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組織特異性：Isoform 1 and isoform 2 are widely expressed. Expressed in various malignant tumor tissues (at protein level).
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數據庫鏈接：
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