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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
May play a role in developmental myelination of peripheral nerves.
基因功能參考文獻:
Ectopic expression of an N-terminal-truncated ARHGEF10 mutant led to the generation of large vesicle-like structures containing both Rab6 and Rab8. PMID: 27550519
This study provided new insights into the roles of ARHGEF10 SNPs rs2280887, rs9657362, and rs4480162 in the development and progression of ischemic stroke in northern Chinese Han population. PMID: 27934548
A significant association of ARHGEF10 with paclitaxel chemotherapy induced peripheral neuropathy was found. PMID: 26143528
Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10). PMID: 21719701
the rs4376531 polymorphism in the ARHGEF10 gene is a risk factor for atherothrombotic stroke in the Han Chinese population PMID: 21743172
The functional single-nucleotide polymorphism of ARHGEF10 confers the susceptibility to atherothrombotic stroke. PMID: 20042462
data support a role for ARHGEF10 in developmental myelination of peripheral nerves PMID: 14508709
Gef10 is the third member of a Rho-specific GEF family with unusual protein architecture PMID: 16896804
A novel RhoA-dependent signaling pathway under the control of ARHGEF10 has a pivotal role in the regulation of the cell division cycle. PMID: 19635168