AQP8 Antibody
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中文名稱：AQP8兔多克隆抗體
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貨號：CSB-PA186529
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA186529(AQP8 Antibody) at dilution 1/75, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：AQP8
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別名：AQP8; Aquaporin-8; AQP-8
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthetic peptide of Human AQP8
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:10000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea.
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基因功能參考文獻：
- Structural basis for mutations in human AQP8 associated with colorectal cancer has been described. PMID: 29799470
- Aquaporin 8 expression is regulated by cholesterol in hepatic cells PMID: 28322010
- The control of AQP8-mediated H2O2 transport provides a novel mechanism to regulate cell signaling and survival during stress. PMID: 26972385
- In particular, AQP8 affected VEGF-induced redox signaling by increasing the sulfenation of the tumor suppressor PTEN, which resulted in its inactivation and, in turn, caused Akt activation. PMID: 27862460
- Aquaporins AQP3, -7, -8, and -11 proteins were found in sperm cells and localized in the head (AQP7), in the middle piece (AQP8) and in the tail (AQP3 and -11) in both the plasma membrane and in intracellular structures. PMID: 28042826
- No significant relationship was found between gallbladder mucosa aquaporin expression and the presence or absence of gallbladder stones. PMID: 26707370
- AQP6 and AQP8 had different expression degrees in epithelial ovarian tissues, which suggests that AQP6 and AQP8 may play certain roles in epithelial ovarian tumors. PMID: 26779650
- EGF induces AQP8 expression and cell migration in Eca-109 cells via the EGFR/Erk1/2 signal transduction pathway. PMID: 25550802
- increased AQP8, Erk1/2 and phosphorylated-Erk1/2 expression may play a role in transformation of cervical intraepithelila neoplasia into cervical cancer, and in early invasion and lymphatic metastasis of cervical cancer PMID: 25120769
- mtAQP8 knockdown induces necrotic cell death in human neoplastic hepatic cells, a finding that might be relevant to therapeutic strategies against hepatoma cells. PMID: 24415197
- AQP8 and its relationship with miRNAs may be involved in the pathogenesis of Ulcerative colitis (UC). PMID: 23595390
- AQP8 has a role in the pathogenesis of PCOS. PMID: 23953589
- the results here reported indicate that AQP8 is able to modulate H2O2 transport through the plasma membrane affecting redox signalling linked to leukaemia cell proliferation PMID: 24440277
- High Aquaporin 8 expression is associated with invasion of cervical cancer. PMID: 23679281
- The expression levels and immunoreactive score of AQP8 protein and mRNA increased in low-grade astrocytomas, and further increased in high-grade astrocytomas, especially in glioblastoma. PMID: 24055034
- AQP8 expression significantly increased in advanced stage of cervical cancer, deeper infiltration, metastatic lymph nodes and larger tumor volume. PMID: 22901156
- Reconstitution of water channel function and 2D-crystallization of human aquaporin 8. PMID: 22192778
- With the increase of cAMP, AQP8 mRNA and protein expressions significantly increased in WISH cells in vitro. PMID: 19087520
- The expression of AQP8 protein is positively correlated with bcl-2 protein in human cervical carcinoma. PMID: 18788571
- The expression of AQP8 mRNA and protein is significantly increased in the amnion and placenta of polyhydramnios, suggesting that AQP8 may play an important role in the regulation of amniotic fluid volume. PMID: 19563057
- When polyhydramnios occurs, expression of aquaporin 8 and aquaporin 9 in fetal membranes and placenta is an adaptive change. PMID: 20732771
- Data show that AQP-1, 3, 8, 9 mRNA expression was detected in both amnion and chorion and can be associated with intramembranous transport and volume regulation of amniotic fluid. PMID: 17545093
- Aquaporin 8 has a role in intramembranous water transport and the balance of amniotic fluid. PMID: 20144166
- Aquaporin 8 is expressed in colonic epithelial cells but was not detected in colorectal tumors. PMID: 11231887
- expression of aquaporin 8 water channel in and up-regulation by second messenger cyclic adenosine monophosphate. Aquaporin 8 messenger RNA has relatively short biologic half-life in vitro. PMID: 12712100
- Upregulation of AQP8 in the colon of ulcerative colitis patients represents a secondary phenomenon which may disturb the physiologic colonic mucus barrier and thus lead to chronic inflammation and ulceration. PMID: 17461471
- Knockdown of hepatocyte aquaporin-8 by RNA interference induces defective bile canalicular water transport. PMID: 18948439
- The crystal structure of deoxyhemoglobin S, 2HBS, demonstrates the interaction of the mutant valine with another hemoglobin tetramer and provides insights into formation of the intracellular sickle cell fiber. PMID: 9325099
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亞細胞定位：Mitochondrion membrane; Multi-pass membrane protein.
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蛋白家族：MIP/aquaporin (TC 1.A.8) family
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組織特異性：Detected in the sperm midpiece (at protein level). Expressed only in pancreas and colon.
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數據庫鏈接：
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