Recombinant Mouse Desert hedgehog protein (Dhh), partial (Active)
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中文名稱:小鼠Dhh重組蛋白
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品名簡稱:Recombinant Mouse Dhh protein, partial (Active)
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貨號:CSB-AP000541MO
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說明書:
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規格:¥852
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圖片:
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其他:
產品詳情
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純度:>98% as determined by SDS-PAGE.
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內毒素:Less than 1.0 EU/μg as determined by LAL method.
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生物活性:Fully biologically active when compared to standard. The ED50 as determined by its ability to induce alkaline phosphatase production by murine MC3T3?E1 cells is 5-20 μg/ml.
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基因名:
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Uniprot No.:
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別名:DhhDesert hedgehog protein; DHH; HHG-3) [Cleaved into: Desert hedgehog protein N-product; Desert hedgehog protein C-product]
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種屬:Mus musculus (Mouse)
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蛋白長度:Partial
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來源:E.Coli
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分子量:20.0 kDa
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表達區域:24-198aa
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氨基酸序列IIGPGRGPVG RRRYVRKQLV PLLYKQFVPS MPERTLGASG PAEGRVTRGS ERFRDLVPNY NPDIIFKDEE NSGADRLMTE RCKERVNALA IAVMNMWPGV RLRVTEGWDE DGHHAQDSLH YEGRALDITT SDRDRNKYGL LARLAVEAGF DWVYYESRNH IHVSVKADNS LAVRAGG
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蛋白標簽:Tag-Free
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產品提供形式:Liquid or Lyophilized powder
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緩沖液:0.2 μm filtered PBS, pH 7.4,1 mM DTT, 0.05 % Tween-80 ,lyophilized
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儲存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:5-10 business days
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Datasheet & COA:Please contact us to get it.
相關產品
靶點詳情
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功能:Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.
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基因功能參考文獻:
- the critical role of Dhh in maintaining blood nerve barrier integrity and demonstrates for the first time that endothelial dysfunction is sufficient to induce neuropathy PMID: 26645982
- In organogenesis of the ovary, production of Dhh/Ihh in granulosa cells requires growth differentiation factor 9 from the oocyte. PMID: 25917826
- increased expression in cell bodies of cutaneous sensory nerves of dorsal root ganglia as compared with skin epithelia PMID: 25842978
- The results demonstrate a pivotal role for dhh in maintof this study aining myelination. Furthermore, dhh signaling reveals a potential target for therapeutic intervention to prevent and treat demyelination of peripheral nerves in compression neuropathies PMID: 25936873
- Hedgehog signaling is impaired in aged mice. Hegdehog-dependent regulation of angiogenesis and myogenesis involves distinct mechanisms. PMID: 24135022
- Data indicate that the centrosomal protein DZIP1 interacts with GLI3 transcription factor in the cytoplasm and regulates Hedgehog signaling and ciliogenesis. PMID: 23955340
- Desert hedgehog promotes ischemia-induced angiogenesis by ensuring peripheral nerve survival. PMID: 23343527
- Desert hedgehog-dependent transcription in T cells promotes T helper (Th)2 cell transcriptional programs and differentiation, exacerbating allergic disease. PMID: 23408837
- During recovery of hematopoiesis after irradiation, and under conditions of stress-induced erythropoiesis, erythrocyte differentiation was accelerated in both spleen and bone marrow of Dhh-deficient mice compared with wild type. PMID: 22461491
- The findings suggest that Sertoli cells coordinate Dhh-dependent spermatogenesis events via Ptc1 and Smo prior to the first meiotic division and in postmeiotic (haploid) cells, particularly during the first half of spermiogenesis. PMID: 19484749
- Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis PMID: 12050120
- transgenic skin developed lesions reminiscent of human basal cell carcinoma PMID: 15371305
- Prominent role of hedgehog signaling in the communication between granulosa cells and developing theca cells. PMID: 15878962
- A single identified glial signal, desert hedgehog, plays a critical role in controlling the integrity of peripheral nervous tissue, in line with its critical role in nerve sheath development. PMID: 16763045
- results demonstrate a functional desert hedgehog(HH) pathway in the follicle and identify granulosa cells as at least one of the potential targets of HH signaling PMID: 17392501
- combinatorial expression of the paracrine factor Dhh and nuclear transcription factor Sf1 is required for Leydig cell development PMID: 17495005
- Inactivation of Nf1 in the glial lineage in vitro at embryonic day 12.5 + 1, but not earlier (neural crest) or later (mature Schwann cell), results in colony-forming cells capable of multilineage differentiation. PMID: 18242511
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亞細胞定位:[Desert hedgehog protein N-product]: Cell membrane; Lipid-anchor; Extracellular side.; [Desert hedgehog protein C-product]: Secreted, extracellular space.
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蛋白家族:Hedgehog family
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組織特異性:Expressed in adult testes. Not expressed in limb buds.
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數據庫鏈接:
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