MME Monoclonal Antibody

說明書

中文名稱：

MME鼠單克隆抗體
貨號(hào)：

CSB-MA000230
規(guī)格：

￥1090
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品描述：

CUSABIO貨號(hào)：CSB-MA000230 MME單克隆抗體是針對(duì)膜金屬內(nèi)肽酶（MME/CD10）研發(fā)的高特異性科研工具，該靶標(biāo)作為Ⅱ型跨膜糖蛋白廣泛分布于細(xì)胞表面，通過水解活性參與神經(jīng)肽代謝、信號(hào)轉(zhuǎn)導(dǎo)及細(xì)胞增殖調(diào)控，在急性淋巴細(xì)胞白血病、三陰性乳腺癌及前列腺癌等惡性腫瘤中呈現(xiàn)特異性高表達(dá)特征。本產(chǎn)品采用小鼠免疫宿主制備，經(jīng)嚴(yán)格驗(yàn)證可特異性識(shí)別人類、小鼠及大鼠來源的MME抗原表位，適用于酶聯(lián)免疫吸附（ELISA）檢測(cè)及免疫組化（IHC）實(shí)驗(yàn)體系。抗體經(jīng)蛋白A純化工藝處理，具備優(yōu)異的批次穩(wěn)定性與低交叉反應(yīng)性，特別適用于腫瘤微環(huán)境研究、干細(xì)胞分化追蹤及疾病相關(guān)分子標(biāo)記物篩選等科研領(lǐng)域。作為MME/CD10檢測(cè)的關(guān)鍵試劑，該產(chǎn)品可為腫瘤發(fā)生機(jī)制研究、藥物靶點(diǎn)驗(yàn)證及生物標(biāo)志物發(fā)現(xiàn)提供可靠的技術(shù)支持，滿足分子病理學(xué)、腫瘤免疫學(xué)等領(lǐng)域的基礎(chǔ)研究需求，助力精準(zhǔn)醫(yī)學(xué)研究的深入開展。
Uniprot No.：

P08473
基因名：

MME
別名：

Atriopeptidase antibody; CALLA antibody; CD10 antibody; CD10 antigen antibody; Common acute lymphocytic leukemia antigen antibody; DKFZp686O16152 antibody; EC 3.4.24.11 antibody; Enkephalinase antibody; EPN antibody; Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase) antibody; Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) antibody; Membrane metallo endopeptidase antibody; Membrane metallo endopeptidase variant 1 antibody; Membrane metallo endopeptidase variant 2 antibody; Membrane metalloendopeptidase antibody; Membrane metalloendopeptidase neutral endopeptidase enkephalinase antibody; Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10 antibody; Membrane metalloendopeptidase variant 1 antibody; Membrane metalloendopeptidase variant 2 antibody; MGC126681 antibody; MGC126707 antibody; MME antibody; NEP antibody; NEP_HUMAN antibody; Neprilysin antibody; neprilysin-390 antibody; neprilysin-411 antibody; Neutral endopeptidase 24.11 antibody; Neutral endopeptidase antibody; Neutral endopeptidase, membrane-associated antibody; SFE antibody; Skin fibroblast elastase antibody
宿主：

Mouse
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Synthetic Peptide
免疫原種屬：

H, M, R
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
克隆號(hào)：

24E3
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.
基因功能參考文獻(xiàn)：
1. showed CD10 positivity in fibroblast-like stromal cells and fibrous material PMID: 29791034
2. these data indicated under cigarette smoke condensate treatment; losing of membrane p120ctn could upregulate surface NEP protein level and thus facilitate BEAS-2B cell migration. PMID: 30249887
3. High expression of CD10 is associated with lymph node invasion in colorectal cancer. PMID: 29653092
4. We observed an increase of VCAM-1 urine levels in diabetic nephropathy-basal patients compared to diabetic controls and an increase of urinary neprilysin in DN-treated patients with persistent albuminuria PMID: 29854824
5. Degradation of tropoelastin and skin elastin by neprilysin PMID: 29196110
6. Xanthorrhizol (Xan) reduced 4-hydroxynonenal (HNE) levels on NEP proteins and preserved enzymatic activities of neprilysin (NEP) in HNE- or oligomeric Abeta42-treated cells. Xan reduced Abeta42 accumulation and protected neurones against oligomeric Abeta42-induced neurotoxicity through preservation of NEP activities PMID: 29330223
7. These findings support the role of the stromal CD10 expression in breast cancer progression and dissemination, and suggest a relationship with cancer stem cells. PMID: 29306324
8. Aberrant CD10 and BCL6 expression defines a subset of MCLs with higher mean Ki-67 index and higher prevalence of MUM1 expression PMID: 28628241
9. Our study firstly confirmed the association of MME miRNA binding site polymorphism with the risk of LOAD. However, the association results warrant further validation. PMID: 28294061
10. the Ras signaling pathway is involved in HIV-1 Tat-induced changes in ZO-1 and NEP. PMID: 28553432
11. In this meta-analysis of the Han Chinese population, neprilysin confers genetic susceptibility to Alzheimer's disease in Han Chinese populations. PMID: 26362309
12. High CD10 expression is associated with lymphoma in Waldeyer ring. PMID: 27616053
13. Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies PMID: 27588448
14. CD10 down expression in follicular lymphoma correlates with gastrointestinal lesion involving the stomach and large intestine PMID: 27513891
15. High CD10 expression is associated with Basal cell carcinoma of the skin. PMID: 27039776
16. the dynamic behavior of human NEP and NEP2 proteins was monitored by conducting molecular dynamics (MD) simulations. PMID: 26846903
17. This study reveals some unusual findings in otherwise classical disease entity, like absence of palpable spleen, presence of lymphadenopathy, normal or elevated leukocyte counts, expression of CD10, which at times could be diagnostically challenging. PMID: 26609034
18. Case Report: endometrial mixed carcinoma with the neuroendocrine component expressing CD10 that showed a long survival. PMID: 26830028
19. CD10 and Bcl2 expression in tumor cells could give convincing diagnostic value to distinguish squamous cell carcinoma from seborrheic keratosis PMID: 26573127
20. The peptide qf-Abeta(12-18)C (sequence VHHQKLVC) was cleaved by multiple Abeta-degrading enzymes, including NEP, ACE, and ECE-1, whereas the redesigned peptide qf-Abeta(12-16)AAC (sequence VHHQKAAC) was sensitive to NEP and ACE only. PMID: 27096746
21. Loss-of-function MME mutations are the most frequent cause of adult-onset autosomal-recessive Charcot-Marie-Tooth disease type 2 in Japan. PMID: 26991897
22. CD10 positivity is luminal/membranous in most benign apocrine breast lesions, the staining being nonuniversal and sometimes focal; analogous staining in apocrine malignancies seems rarer in DCIS and even rarer in invasive apocrine carcinomas, but atypical cytoplasmic positivity may also occur PMID: 26562027
23. These findings indicate that CD10 may promote tumor progression by regulating the expression profiles of genes related to cell proliferation, angiogenesis, and resistance to apoptosis. PMID: 26881775
24. CD10 gene expression plays a role in the pathogenesis of diffuse large B-cell lymphoma. PMID: 26414904
25. High tumoral CD10 expression correlates with aggressive histology in patients with malignant pleural mesothelioma. PMID: 25608772
26. In stage I lung adenocarcinoma, tumoral CD10 correlated with high-grade histology and was an independent predictor of recurrence in intermediate-grade tumors. PMID: 26141216
27. CD10 strongly labelled only the gastrointestinal cells, with a well-defined apical membrane signal PMID: 24754336
28. High CD10 expression is associated with Phylloides Tumors. PMID: 25921112
29. The expression of neprilysin is increased in glioma cells following 5-HT2C activation. PMID: 25452160
30. CD10 expression is related to a distinct gene expression signature in mantle cell lymphoma cases, but is without clinical or biological implications. PMID: 26124315
31. Correlation between CD10 stromal expression and disease-free survival rate in breast cancer patients. PMID: 23575921
32. E-cadherin and CD10 in endometrial lesions is not correlated, but reduced expression of both molecules could be critical for progression of endometrial carcinoma PMID: 25282623
33. Evaulate CD10 and mucin expression in relation to microsatellite instability/mismatch repair proteins in 47 cases of small bowel adenocarcinoma. PMID: 25759539
34. This meta-analysis indicates that rs3736187 (A/G) polymorphisms may be a potential beneficial single nucleotide polymorphism (SNP), which are associated with a decreased risk in Alzheimer disease. PMID: 25125048
35. Follicular lymphoma CD10(pos) follicular helper T cells specifically display an IL-4(hi)IFN-gamma(lo) cytokine profile and encompass the malignant B-cell-supportive follicular helper T cells subset. PMID: 25733581
36. Letter: suggest that CD10 is not a useful marker to differentiate seminoma from non-seminomatous germ cell tumours. PMID: 25713420
37. This study gives substantial proof to the various models/research papers explaining the role of CD10 in breast cancer pathogenesis. PMID: 25308002
38. Immunohistochemical distinction of renal cell carcinoma from other carcinomas with clear-cell histomorphology: utility of CD10 and CA-125 in addition to PAX-2, PAX-8, RCCma, and adipophilin. PMID: 25279712
39. Serum CD10 levels might serve as a useful marker of synchronous and metachronous liver metastasis in colorectal cancer. PMID: 24972738
40. PKCepsilon activation may have therapeutic efficacy for AD by reducing neurotoxic Abeta accumulation as well as having direct anti-apoptotic and synaptogenic effects PMID: 24848988
41. High CD10 expression is associated with squamous cell carcinoma. PMID: 24895167
42. MME expression level was differentially altered in Crohn disease and ulcerative colitis patients. PMID: 23827863
43. the recombinant brain-targeted neprilysin, ASN12, may be an effective treatment for AD and warrant further investigation in clinical trials. PMID: 24825898
44. Expression of CD10 is associated with therapeutic resistance and cancer stem cell-like properties of head and neck squamous cell carcinoma. PMID: 24874475
45. A direct up-regulation of stroma fibroblast MME expression under hypoxia might contribute to enhanced aggressiveness of hypoxic cancers. PMID: 24460801
46. Data indicate an important, previously neglected, role of NEP for regulation of luminal factors in the epididymis and suggest a novel role for CNP/guanylyl cyclase B in the epididymal epithelium. PMID: 24099862
47. only seminomas and intratubular germ cell neoplasia, the precursors of germ cell tumours, express CD10 PMID: 23857215
48. study suggests that the severity of periodontal disease may be associated with the expression of metalloendopeptidase genes, including NEP, ECE1 and ADAM17, in the buccal mucosal epithelium. PMID: 23360525
49. CD10 might be involved in the development of endometriosis due to its influence on CD44-dependent cell adhesion. PMID: 23653392
50. Overexpression of membrane metalloendopeptidase inhibits substance P stimulation of cholangiocarcinoma growth. PMID: 24603459
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相關(guān)疾病：

Charcot-Marie-Tooth disease 2T (CMT2T); Spinocerebellar ataxia 43 (SCA43)
亞細(xì)胞定位：

Cell membrane; Single-pass type II membrane protein.
蛋白家族：

Peptidase M13 family
數(shù)據(jù)庫(kù)鏈接：

HGNC: 7154

OMIM: 120520

KEGG: hsa:4311

STRING: 9606.ENSP00000353679

UniGene: Hs.307734

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