CD1A Monoclonal Antibody

說明書

中文名稱：

CD1A鼠單克隆抗體
貨號：

CSB-MA011008
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

CD1A單克隆抗體（CUSABIO貨號：CSB-MA011008）是針對CD1A跨膜糖蛋白開發的高特異性科研工具。CD1A作為主要組織相容性復合體相關分子，在抗原呈遞過程中發揮關鍵作用，其表達特征與樹突狀細胞分化及T細胞激活密切相關，是研究免疫調節和細胞表面受體的重要生物標志物。本產品通過蛋白A親和層析技術精制，經嚴格質控驗證可特異性識別人、小鼠、大鼠樣本，適配ELISA和免疫組化（IHC）兩大實驗平臺。產品以0.01M TBS緩沖液（pH7.4）為基質，添加1% BSA和50%甘油增強穩定性，建議常規使用4℃短期保存，長期存儲需置于-20℃避免反復凍融。該抗體靶向44kDa的膜蛋白結構域，適用于免疫微環境分析、抗原提呈機制探究及免疫細胞標記等基礎研究，為腫瘤免疫學、感染性疾病模型構建提供優質試劑支持。通過優化抗原表位識別能力，本產品在組織切片染色和蛋白互作檢測中展現出色性能，是探索CD1A介導的脂質抗原呈遞通路及免疫細胞通訊機制的首選工具。
Uniprot No.：

P06126
基因名：

CD1A
別名：

CD1A; T-cell surface glycoprotein CD1a; T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen; CD antigen CD1a
宿主：

Mouse
反應種屬：

Human,Mouse,Rat
免疫原：

Synthetic Peptide
免疫原種屬：

H, M, R
標記方式：

Non-conjugated
抗體亞型：

IgG
克隆號：

4H10
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
基因功能參考文獻：
1. CD1a expression is up-regulated by TSLP (thymic stromal lymphopoietin) at levels observed in the skin of patients with atopic dermatitis, and the response is dependent on PLA2G4A. PMID: 29273672
2. In this review, authors summarize the current knowledge about CD1 proteins, their structures, lipid-binding profiles, and roles in immunity, and evaluate the role of CD1 proteins in eliciting humoral immune response PMID: 28386696
3. CD207(+)CD1a(+) cells are circulating in patients with active Langerhans cell histiocytosis, and TSLP and TGF-beta are potential drivers of Langerhans-like cells in vivo. PMID: 28847997
4. CD1a+ CD11b+ macrophages and NK T-cells were found to be significantly increased in inflamed colons of ulcerative colitis patients. PMID: 27809916
5. The findings suggest that PLA2 inhibition or CD1a blockade may have therapeutic potential for psoriasis. PMID: 27670592
6. these observations suggest that CD99 is involved in the regulation of CD1a transcription and expression by increasing ATF-2. PMID: 27094031
7. this study shows that CD1a drove the pathogenesis of poison-ivy dermatitis and psoriasis, and that CD1a-mediated skin inflammation was abrogated by CD1a-blocking antibodies, which highlights CD1a as a target for treatment of inflammatory skin diseases PMID: 27548435
8. The data show that immunohistochemistry for CD1a and Hsp60 can be of help in differential diagnosis between Keratoacantomas and well-differentiated forms of squamous cell carcinomas. PMID: 26442925
9. NDN and CD1A are novel prognostic methylation markers in patients with head and neck squamous carcinomas PMID: 26518708
10. Findings suggest that dermal survivin+CD1a+ (CD1a antigen) cell infiltration may be a potential biomarker of systemic sclerosis skin lesions. PMID: 26419626
11. plasma-derived lipids drive functional levels of CD1d expression. PMID: 26460687
12. Studies indicate that many CD1 antigen-restricted T cells do not require foreign antigens for activation but instead can be activated by self-lipids presented by CD1. PMID: 26284469
13. High CD1a-positive dendritic cell density is associated with improved disease-free survival in papillary thyroid carcinoma. PMID: 26073685
14. the expression of WNT4, a Wnt ligand, and three targets of Wnt-ss-catenin transcription activation, namely, MMP7, cyclinD1 (CD1) and c-MYC in 141 penile tissue cores from 101 unique samples, were investigated. PMID: 25901368
15. Studies indicate that the antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids and small molecules to T cells. PMID: 26388332
16. The presence of CD1a(+) T-cells in all of the LCH lesions that we have studied to date warrants further investigation into their biological function to determine whether these cells are important in the pathogenesis of LCH PMID: 25343480
17. A polymorphism in human CD1A is associated with susceptibility to tuberculosis. PMID: 24500401
18. [review] Humans express both Group 1 (CD1a, CD1b and CD1c) and Group 2 (CD1d) CD1 molecules with nonredundant functions in response to the presentation of endogenous lipids. PMID: 24556395
19. CD1a deficiency on in vitro-derived DCs was detected in 15% of study subjects. A common SNP in the 5' UTR of CD1a is associated with both low surface expression & mRNA levels. It directly regulates gene expression in a promoter-luciferase assay. PMID: 23858036
20. Case Report: cutaneous-limited self-regressing S100 negative/CD1a positive histiocytosis. PMID: 23334517
21. binding cavity of CD1a is largely preserved in the unliganded state because of persistent electrostatic interactions that keep the portal alpha-helices at a constant separation. PMID: 23677998
22. Dysregulated CD1 profile in myeloid dendritic cells in CVID is normalized by IVIg treatment. PMID: 23766460
23. Molecular mechanisms by which CD1a captures distinct classes of self- and mycobacterial antigens are reviewed. Review. PMID: 23468110
24. these results reveal that CD1 expression is modified in MS and provide novel information on the regulation of lipid antigen presentation in myeloid cells. PMID: 22670773
25. Saposins utilize two strategies for lipid transfer and CD1 antigen presentation PMID: 22331868
26. allelic variation in CD1A does not play a major role in determining multifocal motor neuropathy susceptibility. PMID: 22003931
27. In the intratumoral and peritumoral areas, the expression of CD1a, tryptase, and CD68 was significantly higher in papillary thyroid carcinoma than in thyroid adenomas. PMID: 22007938
28. GM-CSF independent signaling directed toward the CD1a genome is important in Langerhans cell biology. PMID: 21900947
29. In Guillain-Barre syndrome, an initially positive association study with polymorphism of CD1A and CD1E genes was not confirmed PMID: 21696499
30. CD1A and CD1E polymorphisms contribute to the polygenic susceptibility to multiple sclerosis PMID: 21496400
31. We do not believe that there is a role for CD1a immunohistochemistry in the differential diagnosis of perivascular epithelioid cell neoplasms. PMID: 21194729
32. Accumulation of CD1a-positive Langerhans cells and mast cells in actinic cheilitis. PMID: 20890667
33. CD1E and CD1A genes may be involved in networks which determine susceptibility to multiple sclerosis types RR-MS and PP-MS, respectively. PMID: 20954848
34. The quantity of CD1a-positive Langerhans cells in the lesions of epidermodysplasia verruciformis patients was significantly lower than in normal skin. PMID: 19317050
35. microsomal triglyceride transfer protein deficiency was associated with increased proteasomal degradation of group 1 CD1 molecules in human abetalipoproteinemia. PMID: 20592474
36. The effect of transient stimulation of the canonical Wnt pathway in the differentiation potential of Lin(-)CD34(+) CD1a(-) human thymic progenitors, was analyzed. PMID: 19952356
37. Data show high expression of CD86 and CD11C, moderate expression of CD1a and CD123, low levels of CD83 on dendritic cells after induction by GM-CSF and IL-4. PMID: 19257981
38. Data show that the expression of CD1a and CD207 is markedly down-regulated in CA epidermis. PMID: 19426597
39. The intracellular trafficking route of CD1a is essential for efficient presentation of lipid antigens that traffic through the early endocytic and recycling pathways. PMID: 20026739
40. outstanding ability of Langerhans cells to mediate CD1a-dependent lipid antigen presentation and thus, Langerhans-cell-mediated skin immunity may involve T cell recognition of both peptide and lipid antigens. PMID: 12925210
41. CD1a and langerin have roles in antigen presentation to T cells PMID: 14991068
42. Review. CD1a on tumor-infiltrating dendritic cells may present immunogenic tumor-specific glycolipid antigens to T-cells. PMID: 15099564
43. CD1a expression was detected on monocytes in the majority of sickle cell anemia patients, and was predominant in SDPunjab patients. PMID: 15556687
44. structural study illustrates how a single chain lipid can be presented by CD1 and that the peptide moiety of the lipopeptide is recognized by the T cell receptor PMID: 15723809
45. hypothesis that CD1-restricted T cells might be activated and home to target tissues involved in Hashimoto's thyroiditis and Graves' disease PMID: 15749918
46. CD1a may be a novel biomarker for Barrett metaplasia and that its expression may help to predict the prognosis of this pathology. PMID: 15756258
47. identified CD1a-, CD1b-, and CD1c-restricted T cells from normal human donors that induce cytolysis and secrete copious IFN-gamma in response to self-CD1 expressed on monocyte-derived dendritic cells PMID: 16272286
48. In this study, we show that PTX can selectively block the expression of CD1a isoform during the differentiation of human monocytes into dendritic cells. PMID: 16598657
49. In humans, CD1a-expressing antigen- presenting cells located close to the lymphatic vessels in the upper layers of the dermis may fulfill some of the roles previously ascribed to Langerhans cells. PMID: 16670277
50. A 1000-base pair region upstream of CD1A translation start site is identified as necessary for CD1A proximal promoter activity. PMID: 17082618
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein.
組織特異性：

Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.
數據庫鏈接：

HGNC: 1634

OMIM: 188370

KEGG: hsa:909

STRING: 9606.ENSP00000289429

UniGene: Hs.1309

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