Recombinant Mouse Interleukin-9 protein (Il9) (Active)
In Stock-
中文名稱:小鼠Il9重組蛋白
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品名簡稱:Recombinant Mouse Il9 protein (Active)
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貨號:CSB-AP003341MO
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說明書:
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規格:¥2124
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圖片:
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其他:
產品詳情
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純度:>97% as determined by SDS-PAGE.
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內毒素:Less than 1.0 EU/μg as determined by LAL method.
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生物活性:Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine TS1 cells is less than 0.02 ng/ml, corresponding to a specific activity of >5.0x107 IU/mg.
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基因名:
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Uniprot No.:
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別名:Il9; Interleukin-9; IL-9; Cytokine P40; T-cell growth factor P40
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種屬:Mus musculus (Mouse)
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蛋白長度:Full Length of Mature Protein
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來源:E.Coli
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分子量:14.2 kDa
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表達區域:19-144aa
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氨基酸序列QRCSTTWGIR DTNYLIENLK DDPPSKCSCS GNVTSCLCLS VPTDDCTTPC YREGLLQLTN ATQKSRLLPV FHRVKRIVEV LKNITCPSFS CEKPCNQTMA GNTLSFLKSL LGTFQKTEMQ RQKSRP
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蛋白標簽:Tag-Free
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產品提供形式:Liquid or Lyophilized powder
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緩沖液:0.2 μm filtered PBS, pH 7.4 ,lyophilized
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儲存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:5-10 business days
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Datasheet & COA:Please contact us to get it.
相關產品
靶點詳情
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功能:Supports IL-2 independent and IL-4 independent growth of helper T-cells.
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基因功能參考文獻:
- Results indicated that interleukin 9 (IL-9) was an important type of cytokine involved in the progression of Schistosoma japonicum infection-induced hepatic damage. PMID: 28539607
- IL9 CNS-25/IL9 CNS-18 is a critical and conserved regulatory element for IL-9 production in mice and humans. PMID: 30442929
- Data show that interferon regulatory factor 1 (IRF1) occupancy correlates with decreased interferon regulatory factor 4 (IRF4) abundance, suggesting an IRF1-IRF4-binding competition at the interleukin 9 (Il9) locus. PMID: 28497800
- Furthermore, chromatin immunoprecipitation (ChIP) followed by luciferase assays revealed direct binding of Foxo1 to both the Il9 and Irf4 promoters and induces their transactivation. PMID: 29339772
- CXCL10, not CXCL9 or CXCL11, induced IL-9 expression in the liver tissue. PMID: 29860220
- Chronic kidney disease aggravates vein graft disease through mechanisms involving IL-9 and mast cell activation. PMID: 29048463
- the results of this study indicate that environmental cues dictate the instability of the Th9 phenotype, and they suggest approaches to enhance Th9 activity in beneficial immune responses PMID: 28137893
- The germinal center development of memory B cells is promoted by follicular helpter T cell-derived IL-9. PMID: 28650481
- In mice, the absence of IL-9 impaired ILC2 proliferation and activation of regulatory T (Treg) cells, and resulted in chronic arthritis with excessive cartilage destruction and bone loss. PMID: 28714991
- These data indicate that IL-9 is an essential regulator of megakaryopoiesis and a promising therapeutic agent for treatment of thrombocytopenia such as CIT. PMID: 28450306
- Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis. PMID: 26129648
- Our results suggest that The Th9/IL-9 is involved in the pathogenesis of UC. PMID: 26603936
- IL-9 exerted pro-atherosclerotic effects in ApoE-/- mice at least partially by inducing VCAM-1 expression, which mediated inflammatory cell infiltration into atherosclerotic lesions. PMID: 25784693
- IL-9 is dispensable for mucosal mast cell development but is necessary for their effective expansion to promote intestinal mastocytosis and susceptibility to experimental food allergy in an IL-9-dependent autocrine manner. PMID: 26410628
- IL-9 production following chlamydial lung infection is redundant for host defense against the intracellular bacteria PMID: 25646821
- IL-25-stimulated dendritic cells rapidly induced mediators, such as the chemokine CCL17, which, in turn, attracted IL-9-producing T cells PMID: 26371249
- TH9 cells are a major source of IL-9 in models of allergic inflammation and play an important role in mast cell accumulation and activation. PMID: 25746972
- IRF4 binds to the promoters of IL1b and IL9, suggesting that tick-derived sialostatin L suppresses mast cell-derived IL-9 preferentially by inhibiting IRF4. PMID: 26078269
- these data identify TL1A-DR3 interactions as a novel pathway that promotes Th9 differentiation and pathogenicity. TL1A may be a potential therapeutic target in diseases dependent on IL-9. PMID: 25786692
- Neutralizing IL9 antibody phenocopied the effects of IL9 gene deletion. PMID: 25297635
- IL-9 can promote interstitial cells of Cajal (ICC) growth and help maintain ICC functions. PMID: 24755995
- Th2 lymphocytes migrating to the bone marrow under high-altitude hypoxia promote erythropoiesis via activin A and interleukin-9. PMID: 24769210
- results suggest that Foxp3 Treg suppress sufficient IL-9 production for subsequent mast cell degranulation during S. ratti infection in a non-redundant manner in BALB/c mice PMID: 24516385
- This study demonstrates that IL-9, through its direct effects on Th1 and ability to promote IL-4 secretion, has a regulatory role for Th1 lymphocytes in allergic contact dermatitis. PMID: 24487305
- In experimental autoimmune encephalomyelitis, forced expression of BCL6 in myelin oligodendrocyte glycoprotein35-55-specific Th9 cells resulted in decreased IL-9 production and induction of IFN-gamma PMID: 24879792
- The activator protein 1 (AP1) family transcription factor BATF (B cell, activating transcription factor-like) was among the genes enriched in Th9 cells and was required for the expression of IL-9 and other Th9-associated genes. PMID: 24216482
- IL-9 has a unique role as an autocrine amplifier of ILC2 function, promoting tissue repair in the recovery phase after helminth-induced lung inflammation PMID: 24249111
- TGF-beta signaling regulated IL-9 production through displacement of EZH2 and removal of suppressive H3K27 histone modification at the Il9 locus. PMID: 24108699
- There is a critical and nonredundant role for Th9 cells and IL-9 in host-protective type 2 immunity against parasitic worm infection. PMID: 24138883
- This study demonstrates that intestinal IL-25 promotes protective immunity against T. spiralis infection by inducing antigen-specific Th9 immune response. PMID: 23897610
- We propose that Smad2/3 and IRF4 cooperatively transactivate the Il9 promoter and play an important role in regulating allergic immune responses by inducing Th9 cells. PMID: 23913959
- Il9r(-/-) mice showed accelerated tumor growth. Recombinant IL-9 given to tumor-bearing WT & Rag1(-/-) mice inhibited melanoma & lung carcinoma growth, suggesting a role for IL9 in tumor immunity. PMID: 22772464
- IL-9-producing invariant NKT cells protect against DSS-induced colitis in an IL-4-dependent manner. PMID: 22892939
- A PU.1-dependent mechanism alters histone acetylation and expression of the interleukin (Il)9 locus in T helper (Th)9 cells. PMID: 22904310
- propose that Notch and Smad3 cooperate to induce IL-9 and participate in regulating the immune response PMID: 22503540
- data established a transcription factor network that regulates IL-9 PMID: 22180613
- data suggest that sialostatin L can prevent experimental asthma, most likely by inhibiting the IL-9 production of Th9 cells PMID: 22327077
- production is largely restricted to innate lymphoid cells in experimental lung inflammation PMID: 21983833
- Data show that IL-9(-/-) mice developed significantly less severe EAE than their WT counterparts. PMID: 21674475
- data show that neoplastic mast cells (MC) express IL-9 receptors, that IL-9 and NPM-ALK upregulate MC-production in vivo, and that both'hits' act in concert to induce a mastocytosis-like disease in mice PMID: 21297223
- IL-9-producing CD4-positive T cells are induced in an IL-4-dependent manner. PMID: 21346235
- results demonstrate a previously unappreciated role for IL-9 in dampening the pathogenic activities of Th17 cells PMID: 21360526
- The nephroprotective, anti-inflammatory effects of regulatory T cells critically depend on IL-9-mediated attraction of mast cells into kidney-draining lymph nodes. PMID: 21115728
- protective effect of IL-9 blockade in EAE was likely mediated via inhibition of the development of MOG peptide-specific T cells, which in turn led to reduced infiltration of T cells into the CNS PMID: 20805418
- data clearly demonstrate the central function of interferon regulatory factor 4 in the development of T helper 9 cells and underline the contribution of this T helper cell subset to the pathogenesis of asthma. PMID: 20674401
- the chronic OVA challenge protocol in BALB/c mice provides a model to study the mechanism of bronchial mast cell accumulation, and bronchial mast cell accumulation in chronic OVA challenged mice is independent of IL-9 in this model PMID: 20480160
- a critical role for PU.1 in generating the IL-9-producing (T(H)9) phenotype and in the development of allergic inflammation PMID: 20431622
- These studies indicate differential involvement of the IL-9/IL-9R pathway in systemic and oral antigen-induced anaphylaxis. PMID: 20159257
- IL-25 is a newly identified regulator of IL-9 expression. PMID: 20154671
- expression in anaplastic large-cell lymphoma PMID: 12555065
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亞細胞定位:Secreted.
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蛋白家族:IL-7/IL-9 family
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