1. Data show that aging is associated with reduction in superoxide dismutase (SOD) Cu/Zn-SOD protein expression and total SOD enzymatic activity in mesenteric lymphatic vessel (MLV). PMID: 22540739
2. The impact of SOD3 on Akt and Erk1/2 cell survival pathways in rat hind limb injury model, is reported. PMID: 21909393
3. ER stress leads to the down-regulation of claudin-5 among tight junction proteins and may induce the elevation of endothelial permeability and leakage of EC-SOD into the vitreous body. PMID: 21736484
4. These data are important for understanding the pathogenesis of vascular diseases in which the synthesis of endothelial NO is decreased or extracellular O2- production exceeds the functional capacity of SOD3. PMID: 20033309
5. Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase PMID: 11861638
6. Levels are not significantly altered in the rat prostate during aging and thus is unlikely to be an important factor in the evolution of epithelial cell hyperplasia PMID: 16372329
7. EcSOD, CuZnSOD, catalase, and MMP-2 mRNA expression did not statistically vary between aortic aneurysm and normal tissue PMID: 17196988
8. SOD3 minimizes O2- levels preserving NO availability at resting conditions. SOD3 promotes NO mediated vasodilatation by scavenging O2- and basal SOD3 levels is able to inactivate O2- produced by 100% oxygen breathing preserving vasodilator effect of NO. PMID: 19198181
9. SOD3 has a selective anti-inflammatory role in ischemic damages preventing the migration of reactive oxygen producing monocyte/macrophages PMID: 19495415

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KEGG: rno:25352

STRING: 10116.ENSRNOP00000005155

UniGene: Rn.10358