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中文名稱：大鼠Tau蛋白酶聯(lián)免疫試劑盒
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貨號：CSB-E13729r
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規(guī)格：96T/48T
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價格：￥3900/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：大鼠Tau蛋白酶聯(lián)免疫試劑盒（CSB-E13729r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、腦脊液（CSF）樣本中的MAPT含量。MAPT基因編碼tau蛋白，是神經(jīng)退行性疾病如額顳葉癡呆（FTDP-17）、阿爾茨海默病（AD）等的關(guān)鍵基因。其突變導(dǎo)致tau蛋白與微管結(jié)合能力下降，引發(fā)神經(jīng)纖維纏結(jié)，進而導(dǎo)致神經(jīng)元損傷。研究MAPT基因突變與tau蛋白功能異常的機制，有助于開發(fā)針對神經(jīng)退行性疾病的診斷和治療策略。試劑盒檢測范圍為62.5 pg/mL-4000 pg/mL，適用于動態(tài)監(jiān)測實驗動物模型中Tau蛋白的表達變化；適用于神經(jīng)系統(tǒng)疾病的基礎(chǔ)研究、藥物干預(yù)效果評估或病理進程分析；為神經(jīng)生物學(xué)、藥理學(xué)及疾病機制探索提供高效工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名：Mapt ELISA Kit; Mtapt ELISA Kit; Tau ELISA Kit; Microtubule-associated protein tau ELISA Kit; Neurofibrillary tangle protein ELISA Kit; Paired helical filament-tau ELISA Kit; PHF-tau ELISA Kit
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縮寫：
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Uniprot No.：
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種屬：Rattus norvegicus (Rat)
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樣本類型：serum, plasma, cerebrospinal fluid (CSF)
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檢測范圍：62.5 pg/mL-4000 pg/mL
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靈敏度：15.6 pg/mL
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反應(yīng)時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領(lǐng)域：Signal Transduction
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of rat tau proteins in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:5 Average % 98 Range % 95-101 1:10 Average % 90 Range % 88-92 1:20 Average % 85 Range % 81-89 1:40 Average % 98 Range % 95-101 -
回收率：
The recovery of rat tau proteins spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 101 99-105 EDTA plasma (n=4) 87 84-90 -
標準曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
pg/ml OD1 OD2 Average Corrected 4000 2.694 2.678 2.686 2.523 2000 2.104 2.156 2.130 1.967 1000 1.330 1.356 1.343 1.180 500 0.825 0.836 0.831 0.668 250 0.552 0.568 0.560 0.397 125 0.359 0.368 0.364 0.201 62.5 0.276 0.298 0.287 0.124 0 0.167 0.159 0.163 -
數(shù)據(jù)處理：
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貨期：3-5 working days
引用文獻
- A high cholesterol diet accelerates Alzheimer's progression by promoting fibrotic damage in rats A Das, D Chowdhury, D Sharma, R Manna,Brain Disorders,2025
- Mogu?nost razvoja netransgeni?noga ?takorskoga modela tauopatije primjenom tau oligomera u entorinalnu mo?danu koru LL Horvat,Dissertations & Theses,2022
- HSV-1 infection induces phosphorylated tau propagation among neurons via extracellular vesicles V Protto, MT Miteva, F Iannuzzi, ME Marcocci,mBio,2024
- Natural inhibitors for acetylcholinesterase and autophagy modulators as effective antagonists for tau and β-amyloid in Alzheimer's rat model M Hassan,Biomarkers,2023
- Anti-aging trait of whey protein against brain damage of senile rats ME El-Beeh,Anti-aging trait of whey protein against brain damage of senile rats,2022
- Neuroprotective effect of peanut against oxidative stress in streptozotocin-induced diabetic rats NH Mohamed,Egyptian Journal of Basic and Applied Sciences,2022
- Electroacupuncture improves cognitive deficits and insulin resistance in an OLETF rat model of Al/D-gal induced aging model via the PI3K/Akt signaling pathway X Huang,Brain Res,2020
- The potential value of capsaicin in modulating cognitive functions in a rat model of streptozotocin-induced Alzheimer’s disease Manal A. Shalaby, et al,Febs Journal,2019
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靶點詳情
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功能：Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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亞細胞定位：Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Secreted.
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組織特異性：Expressed in neurons. The larger forms (isoform tau-A and isoform tau-B) are preferentially expressed in the peripheral nervous system while the other are expressed in the central nervous system. Low amounts of the larger forms are also found in limited a
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數(shù)據(jù)庫鏈接：
STRING: 10116.ENSRNOP00000006856
UniGene: Rn.2455
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