Rat Macrophage Colony-Stimulating Factor,M-CSF ELISA kit
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中文名稱(chēng)：大鼠巨噬細(xì)胞集落刺激因子(M-CSF)酶聯(lián)免疫試劑盒
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貨號(hào)：CSB-E07424r
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規(guī)格：96T/48T
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價(jià)格：￥3900/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：大鼠巨噬細(xì)胞集落刺激因子(M-CSF)酶聯(lián)免疫試劑盒（CSB-E07424r）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織培養(yǎng)上清液、組織勻漿樣本中的CSF1含量。CSF1即集落刺激因子 1，是一種能刺激單核巨噬細(xì)胞前體細(xì)胞增殖和分化的細(xì)胞因子。其研究機(jī)制主要圍繞它與其受體 CSF1R 相互作用展開(kāi)，在免疫調(diào)節(jié)、組織修復(fù)等方面發(fā)揮作用，也和腫瘤微環(huán)境形成、炎癥性疾病發(fā)生發(fā)展有關(guān)。試劑盒檢測(cè)范圍為0.156 ng/ml- 10 ng/ml，靈敏度為0.039 ng/ml。適用于科研領(lǐng)域中評(píng)估大鼠感染模型、自身免疫性疾病研究或藥物干預(yù)實(shí)驗(yàn)中M-CSF的動(dòng)態(tài)表達(dá)，亦可用于體外培養(yǎng)巨噬細(xì)胞功能研究時(shí)的細(xì)胞因子分泌檢測(cè)。實(shí)驗(yàn)操作兼容多種生物樣本類(lèi)型，配備標(biāo)準(zhǔn)化校準(zhǔn)品與緩沖體系，可滿足基礎(chǔ)研究、病理機(jī)制探索及生物標(biāo)志物分析等多元化需求。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
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別名：Csf1 ELISA kit; CsfmMacrophage colony-stimulating factor 1 ELISA kit; CSF-1 ELISA kit; MCSF) [Cleaved into: Processed macrophage colony-stimulating factor 1] ELISA kit
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縮寫(xiě)：
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Uniprot No.：
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種屬：Rattus norvegicus (Rat)
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樣本類(lèi)型：serum, plasma, cell culture supernates, tissue homogenates
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檢測(cè)范圍：0.156 ng/ml - 10 ng/ml
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靈敏度：0.039 ng/ml
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反應(yīng)時(shí)間：1-5h
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樣本體積：50-100ul
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檢測(cè)波長(zhǎng)：450 nm
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研究領(lǐng)域：Cardiovascular
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測(cè)定原理：quantitative
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測(cè)定方法：Sandwich
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精密度：
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線性度：
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回收率：
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標(biāo)準(zhǔn)曲線：
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數(shù)據(jù)處理：
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貨期：3-5 working days
引用文獻(xiàn)
- Mesenchymal Stem Cells and Myeloid-Derived Suppressor Cells Interplay in Adjuvant-Induced Arthritis Rat Model FAM Abo-Aziza,International immunopharmacology,2023
- Reversing Postcardiopulmonary Bypass Associated Cognitive Dysfunction Using k-Opioid Receptor Agonists to Regulate Microglial Polarization via the NLRP3/Caspase-1 Pathway Pei Song,Journal of Healthcare Engineering,2021
- EXPANSION, ACTIVATION AND FUNCTION PROMOTION OF MYELOID-DERIVED SUPPRESSOR CELLS IN ADJUVANT-INDUCED ARTHRITIS Abd-Elhalem S S, et al,European Journal of Biomedical,2019
- Functionalized cerium oxide nanoparticles mitigate the oxidative stress and pro-inflammatory activity associated to the portal vein endothelium of cirrhotic rats Ribera J, et al,Plos One,2019
- Elderly-onset hereditary pulmonary alveolar proteinosis and its cytokine profile Masayuki Ito.et al,BMC Pulmonary Medicine,2017
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靶點(diǎn)詳情
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功能：Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
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相關(guān)疾病：A defect in Csf1 is the cause of the toothless phenotype (tl). Toothless rats display osteoclastopenia, severe osteopetrosis, and dystrophic growth plates.
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亞細(xì)胞定位：Cell membrane; Single-pass type I membrane protein.; [Processed macrophage colony-stimulating factor 1]: Secreted, extracellular space.
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數(shù)據(jù)庫(kù)鏈接：
STRING: 10116.ENSRNOP00000025221
UniGene: Rn.83632
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