Stimulates the release of gastrin and other gastrointestinal hormones. Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake.

1. These results suggest that androgen surge during male puberty plays an important role in the development and maintenance of the male-specific GRP function in the rat spinal cord. PMID: 26860455
2. feeding responses evoked by the large molecular form of gastrin releasing peptide (GRP) in the rat PMID: 24993846
3. all forms of GRP reduce food intake in obese and lean adult Zucker rats similar to Bn in weanling rats. PMID: 24874706
4. The site of action of rat gastrin releasing peptide, in regulation of meal size and intermeal interval, is most likely the stomach and/or the duodenum. PMID: 24556509
5. Gastrin-releasing peptide terminals were found in spinal dorsal horn and trigeminal ganglion. PMID: 24254931
6. GRP regulation of meal size and intermeal interval occurs at different sites in the rat. PMID: 24291388
7. Gastrin-releasing peptide acts via postsynaptic bombesin type 2 receptors to modulate inward rectifier K+ and TRPV1-like conductances in rat paraventricular thalamic neurons PMID: 23359674
8. reduction of meal size and prolongation of intermeal interval (IMI) by GRP-29 require vagal and splanchnic nerves, and the duodenum is the major conduit that communicates prolongation of IMI by GRP-29 with the brain PMID: 22210008
9. With increasing levels of fear, levels of gastrin-releasing peptide (Grp) are increased in medial prefrontal cortex and basolateral amygdala. PMID: 20974156
10. GRP-29 and GRP-27 reduced the size of the first meal, prolonged intermeal interval and increased satiety ratio, but GRP-10 failed to exhibit similar feeding responses. The data support a role for GRP-29 in the short-term regulation of food intake. PMID: 21055429
11. These high-voltage electron microscopy findings provide an ultrastructural basis for understanding how the spinal GRP system regulates male sexual behavior. PMID: 19864484
12. Data suggest that GRP, by acting on GRP receptors but not via CRF receptors, increases 5-HT neuronal activity in the paraventricular nucleus. PMID: 12138009
13. GRP in the central part of the amygdala inhibits feeding, may decrease the efficiency of eating, and may act as a satiety signal. PMID: 12419521
14. the increase in gastrin relesing peptide synthesis in the neurosecretory structures of the hypothalamus shoud be regarded as a compensatory reaction in diabetes PMID: 12469881
15. GRP mRNA was detected in rat kidney from embryonic day 19 to postnatal day 30 by RT-PCR PMID: 15140764
16. Data suggest that GRP does affect the stress response. GRP alterations selectively affected fear-related responses. PMID: 17335915
17. Food deprivation and stimulation of the melanocortin system produce opposing changes in GRP gene expression in the PVN; GRP-containing neurons in the PVN may be part of the hypothalamic signaling pathway controlling food intake and energy balance. PMID: 18818295
18. the spinal GRP system appears to be a stress-vulnerable center for male reproductive functions PMID: 19169356
19. Results suggest that androgen signaling plays a pivotal role in the regulation of GRP expression in male lumbar spinal cord. PMID: 19359382

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Secreted. Cytoplasmic vesicle, secretory vesicle lumen.

Bombesin/neuromedin-B/ranatensin family

KEGG: rno:171101

STRING: 10116.ENSRNOP00000022845

UniGene: Rn.10930