1. co-regulation of the enzyme glutaminyl cyclase and its substrate TRH was reflected by a co-induction of both proteins in reactive astrocytes in proximity of Abeta deposits PMID: 25446989
2. RXRA and RXRB display specific roles in modulating T3-dependent regulation of thyrotropin releasing hormone. PMID: 23896434
3. Reversal of hypothyroidism in female patient after treatment with thyrotropin releasing hormone. PMID: 6432893
4. Data suggest that expression of TRH is up-regulated by CREM (cAMP responsive element modulator protein) in hypothalamus; however, regulation of TRH by triiodothyronine appears independent of CREM or CREB (cAMP responsive element binding protein). PMID: 23000398
5. Thyrotropin-releasing hormone altered the basal expression of the TSHbeta gene and the responsiveness of the gene to thyroid hormone. PMID: 22792320
6. Klf4 plays a key role in the maturation of TRH expression in hypothalamic neurons. PMID: 21182892
7. Data demonstrate that the distribution of hypophysiotropic TRH neurons in mice is vastly different from the pattern in rats, with a dominant occurrence of these neurosecretory cells in the compact part and adjacent regions at the mid-level of the PVN. PMID: 20737594
8. These demonstrations of PPARgamma effects on hypothalamic Trh transcription in vivo consolidate the role of the TRH neuron as a central integrator of energy homeostasis. PMID: 19900503
9. study provides functional in vivo data showing that both thyroid hormone receptor beta1 and beta2 isoforms have specific roles in regulating thyrotropin releasing hormone transcription PMID: 14726446
10. Detailed analysis of TRH-knockout mice might provide insight into physiological significance of endogenous TRH. Present review focuses on phenotypic findings of mice deficient in TRH. PMID: 14751031
11. Expression of thyrotorpin receptors 1 and 2, key elements in TRH regulation, was modified by thyroid status in the hypothalamus but not in the cortex. PMID: 15225659
12. TRH is absolutely required for both TSH and TH synthesis but is not necessary for thyrotroph cell development PMID: 16339138
13. TRH is not essential for pregnancy and lactation, but is required for full function of the lactotrophs, and the PRL mRNA level in the pituitary is regulated by TRH, both directly and indirectly via thyroid hormone PMID: 16484326
14. Trh is expressed dynamically and specifically in the developing mouse definitive endoderm from E7.0 to E8.5 PMID: 17849455
15. TRH neurons in the hypothalamic paraventricular nucleus suggest that CB1 endocannabinoids may influence both excitatory and inhibitory inputs of these neurons. PMID: 18818298
16. provide evidence in mice that TSH participates in this photoperiodic signal transduction PMID: 19015516
17. Results identify TRH as a modulator of orexin neuron firing in the hypothalamus, and suggest that orexin cell excitation may contribute to the arousal-enhancing actions of TRH. PMID: 19204048
18. TRH modulates behavioral arousal, in part, through the Hcrt system. PMID: 19321767
19. Direct receptor-mediated excitation of histaminergic tuberomamillary neurons by TRH demands activation of nonselective cation channels as well as electrogenic sodium/divalent calcium ion exchange. PMID: 19357273
20. Released TRH is inactivated by an ectopeptidase, pyroglutamyl aminopeptidase II (PPII). Acute administration of alcohol modulates pyroglutamyl amino peptidase II activity and mRNA levels in rat limbic regions. PMID: 15707699
21. There is considerable evidence linking alcohol consumption, sedation, and thyrotropin-releasing hormone (TRH) in the brain septum. PMID: 15240370

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KEGG: mmu:22044

STRING: 10090.ENSMUSP00000006046

UniGene: Mm.1363