Mouse amyloid beta peptide 1-40,Aβ1-40 ELISA Kit
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中文名稱：小鼠β淀粉樣蛋白1-40(Aβ1-40)酶聯(lián)免疫試劑盒
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貨號(hào)：CSB-E08300m
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規(guī)格：96T/48T
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價(jià)格：￥3800/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：小鼠β淀粉樣蛋白1-40(Aβ1-40)酶聯(lián)免疫試劑盒（CSB-E08300m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的Aβ1-40含量。Aβ1-40是一種淀粉樣蛋白，是阿爾茨海默病（AD）病理過程中的關(guān)鍵分子。它是淀粉樣蛋白前體蛋白（APP）的代謝產(chǎn)物，通過β-折疊結(jié)構(gòu)聚集形成老年斑，對神經(jīng)細(xì)胞產(chǎn)生毒性，導(dǎo)致神經(jīng)元損傷和認(rèn)知功能下降。Aβ1-40的研究有助于揭示AD的發(fā)病機(jī)制，并為開發(fā)新的治療策略提供靶點(diǎn)。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，主要應(yīng)用于神經(jīng)科學(xué)領(lǐng)域的基礎(chǔ)研究，包括阿爾茨海默病小鼠模型建立、藥物干預(yù)后Aβ代謝通路評估、神經(jīng)毒性作用機(jī)制探索等方向，為病理機(jī)制解析和潛在治療策略開發(fā)提供可靠數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名：amyloid beta peptide 1-40,Aβ1-40,amyloid β peptide 1-40
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縮寫：Aβ1-40
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種屬：Mus musculus (Mouse)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：31.25 pg/mL-2000 pg/mL
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靈敏度：7.8 pg/mL
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反應(yīng)時(shí)間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領(lǐng)域：Neuroscience
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of mouse Aβ1-40 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 89 Range % 80-97 1:2 Average % 95 Range % 90-105 1:4 Average % 95 Range % 83-100 1:8 Average % 93 Range % 83-98 -
回收率：
The recovery of mouse Aβ1-40 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 97 93-106 EDTA plasma (n=4) 89 86-92 -
標(biāo)準(zhǔn)曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
pg/ml OD1 OD2 Average Corrected 2000 2.637 2.739 2.688 2.512 1000 2.115 2.092 2.104 1.928 500 1.318 1.287 1.303 1.127 250 0.824 0.810 0.817 0.641 125 0.491 0.504 0.498 0.322 62.5 0.322 0.315 0.319 0.143 31.25 0.265 0.273 0.269 0.093 0 0.172 0.180 0.176 -
數(shù)據(jù)處理：
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貨期：3-5 working days
引用文獻(xiàn)
- A Novel Missense Variant in SORBS2 Is Causative With Familial Alzheimer's Disease Q Wang, S Wang, S Cao, Q Wang, Y Wei,CNS Neuroscience & Therapeutics,2025
- Inhibition of Amyloid-β (Aβ)-Induced Cognitive Impairment and Neuroinflammation in CHI3L1 Knockout Mice through Downregulation of ERK-PTX3 Pathway HJ Ham,International journal of molecular sciences,2024
- Yuanzhi Powder Facilitated the Aβ Clearance in App/Ps1 Mice: Target to the Drainage of Glymphatic System and Meningeal Lymphatic Vessels J Li,Available at SSRN 4528275,2023
- Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer's disease W Li,BMC medicine,2023
- TNIP2 Inhibits Amyloidogenesis by Regulating the 3'UTR of BACE1 L Wang,Neuroscience letters,2023
- TNIP2 inhibits amyloidogenesis by regulating the 3'UTR of BACE1: an in vitro study L Chen,Neuroscience letters,2023
- Persimmon leaf extract alleviates chronic social defeat stress-induced depressive-like behaviors by preventing dendritic spine loss via inhibition of serotonin?… H Yu,Chinese medicine,2022
- Hippocampal CysLT1R overexpression or activation accelerates memory deficits, synaptic dysfunction, and amyloidogenesis in young APP/PS1 transgenic mice SC Fang,Annals of translational medicine,2021
- Dimethyl fumarate abridged tauo-/amyloidopathy in a D-Galactose/ovariectomy-induced Alzheimer's-like disease: Modulation of AMPK/SIRT-1, AKT/CREB/BDNF, AKT/GSK-3β, Adiponectin/Adipo1R, and NF-κB/IL-1β/ROS trajectories IM Abd El-Fatah,Neurochemistry International,2021
- Dysregulated APP expression and α-secretase processing of APP is involved in manganese-induced cognitive impairment Y Yang,Ecotoxicology and Environmental Safety,2021
- Suan-Zao-Ren Decoction ameliorates synaptic plasticity through inhibition of the Aβ deposition and JAK2/STAT3 signaling pathway in AD model of APP/PS1 transgenic mice Qing-Hua Lon,BMC Chinese Medicine,2021
- Polyunsaturated fatty acid supplement alleviates depression-incident cognitive dysfunction by protecting the cerebrovascular and glymphatic systems X Liu,Brain Behav. Immun,2020
- Bee venom phospholipase A2 ameliorates amyloidogenesis and neuroinflammation through inhibition of signal transducer and activator of transcription-3 pathway in Tg2576 mice Ham H J, et al,Translational Neurodegeneration,2019
- Albiflorin ameliorates memory deficits in APP/PS1 transgenic mice via ameliorating mitochondrial dysfunction Xu YJ,Brain Research,2019
- MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation Zhu BL, et al,Brain,2019
- Knockdown of BACE1 Wenting Zhang.et al,EXP THER MED,2018
- Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer\'s Disease Kuang X.et al,Front Aging Neurosci,2017
- Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice Neuroscience.et al,Neuroscience,2017
- The therapeutic protection of a living and dead Lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice Tian F.et al,PLoS One.,2017
- Lactobacillus plantarum CCFM639 can prevent aluminium-induced neural injuries and abnormal behaviour in mice Leilei Yu.et al,Journal of Functional Foods,2017
- 1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing A尾1-40 brain-to-blood efflux and peripheral uptake transport. Guo YX.et al,Neuroscience.,2016
- Antidiabetic drugs restore abnormal transport of amyloid-ß across the blood-brain barrier and memory impairment in db/db mice Chen F. et al,Neuropharmacology,2015
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■ 常見問題解答
Q:
Hi I would like to ask the following for the item Mouse amyloid beta peptide 1-40 ELISA kits:
1. How may test samples can be performed in 1 kit, is it possible to use the kit for 1 96-well plate
A:
Thanks for your inquiry. This is a sandwich ELISA kit (double-antibody). For a 96T sandwich ELISA kit, we suggest you run duplicates for the standard. In this way you can test 80 samples. We also suggest you run duplicates for the sample, and in this way you can test 40 samples. You can decide how many kits you need according to the number of your samples. If you run a pre-test, the number of samples you can detect in one kit will be less.
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