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中文名稱：小鼠血管內皮細胞粘附分子1(VCAM-1/CD106)酶聯免疫試劑盒
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貨號：CSB-E04754m
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規格：96T/48T
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價格：￥3800/￥2500
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其他：
產品詳情
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產品描述：小鼠血管內皮細胞粘附分子1(VCAM-1/CD106)酶聯免疫試劑盒（CSB-E04754m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養上清液、組織勻漿樣本中的VCAM1含量。VCAM1（血管細胞粘附分子1）是一種細胞表面糖蛋白，屬于免疫球蛋白超家族。它主要在活化的內皮細胞表面表達，通過與白細胞表面的特定分子結合，調節炎癥反應和白細胞遷移。VCAM1在免疫反應和炎癥過程中發揮重要作用，其表達增加與多種免疫性疾病和癌癥的進展密切相關。研究顯示，VCAM1通過調節小膠質細胞的功能和Aβ的清除，在阿爾茨海默病的發生發展中扮演關鍵角色。試劑盒檢測范圍為39.062 pg/mL-2500 pg/mL，靈敏度為29.649 pg/mL。適用于體外研究血管內皮細胞活化狀態、炎癥反應機制、藥物干預效果評估等科研領域，為心血管疾病、免疫調控及腫瘤微環境等領域的機制研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：Vcam1; Vcam-1; Vascular cell adhesion protein 1; V-CAM 1; VCAM-1; CD antigen CD106
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縮寫：
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Uniprot No.：
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種屬：Mus musculus (Mouse)
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樣本類型：serum, plasma, cell culture supernates, tissue homogenates
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檢測范圍：39.062 pg/mL-2500 pg/mL
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靈敏度：29.649 pg/mL
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Cardiovascular
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV%<10%
Three samples of known concentration were tested in twenty assays to assess.
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線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of mouse VCAM-1/CD106 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
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標準曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
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數據處理：
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貨期：3-5 working days
引用文獻
- Lead-induced actin polymerization aggravates neutrophil extracellular trap formation and contributes to vascular inflammation Q Nong, Y Wu, S Liu, Y Tang, J Wu, H Huang,Ecotoxicology and Environmental Safety,2025
- The synergistic effect of Ficus carica nanoparticles and Praziquantel on mice infected by Schistosoma mansoni cercariae NA El-Attar, MR El-Sawi, EA El-Shabasy,Scientific Reports,2024
- Estimation the Effect of Ficus carica Active components' Nanoparticles on Mice Infected by Schistosomal cercariae and treated with praziquantel NA El,/,2024
- Wenyang Huazhuo Tongluo formula alleviates pulmonary vascular injury and downregulates HIF-1α in bleomycin-induced systemic sclerosis mouse model K Li,BMC complementary medicine and therapies,2022
- A Novel STAT3-Mediated GATA6 Pathway Contributes to tert-Butylhydroquinone- (tBHQ-) Protected TNFα-Activated Vascular Cell Adhesion Molecule 1 (VCAM-1) in Vascular Endothelium L Zhou,Oxidative Medicine and Cellular Longevity,2020
- MicroRNA-29a-3p Reduces TNFa-Induced Endothelial Dysfunction by Targeting Tumor Necrosis Factor Receptor X Deng,Mol Ther Nucleic Acids,2020
- Plasma endothelial cells-derived extracellular vesicles promote wound healing in diabetes through YAP and the PI3K/Akt/mTOR pathway F Wei,Aging (Albany NY),2020
- MicroRNA-29a-3p reduces TNFα-induced endothelial dysfunction by targeting tumor necrosis factor receptor 1 Deng X, et al,Molecular Therapy-Nucleic Acids,2019
產品評價
相關產品
靶點詳情
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最新研究進展：VCAM1是一種黏附分子，參與細胞黏附和遷移過程，已被證實與許多疾病的發生和發展有關，如動脈粥樣硬化和腫瘤的形成。最新的研究表明，VCAM1可能參與心血管疾病的發生和發展，并被認為是一種治療心血管疾病的潛在靶點。此外，VCAM1的水平還可以作為某些疾病的診斷和預后標志物。
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功能：Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
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亞細胞定位：[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor.
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組織特異性：Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.
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數據庫鏈接：
STRING: 10090.ENSMUSP00000029574
UniGene: Mm.440909
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